Week 6 NFL Odds: Spreads, Moneylines, & Totals For All 14 Games


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Week 6 NFL Odds: Opening Spreads, Moneylines, & Totals For All 14 Games

NFL Week 6 odds are out, and the action kicks off Thursday with an NFC West showdown between the Seattle Seahawks and San Francisco 49ers. Sunday features 12 games, with a Jets and Bills AFC East clash capping the week on Monday night.

NFL underdogs of 5.5 points or more are 19-4-1 against the spread and 13-11 straight-up through the first five weeks, on pace for an NFL record. Week 6 includes multiple games with a touchdown or more on the spread, with the Lions at the Cowboys and the Buccaneers at the Saints highlighting some of the most anticipated matchups at sportsbooks.

Below is a full breakdown of NFL Week 6 odds. Our odds board will compare lines so you can shop for the best odds at multiple NFL betting sites.

NFL Week 6 odds: Spreads, lines, totals

NFL Week 6 opening spreads, moneylines, totals

MatchupSpreadMoneylineOver/under
San Francisco 49ers vs. Seattle Seahawks49ers -3.549ers -155, Seahawks +13047.5
Jacksonville Jaguars vs. Chicago BearsBears -2.5Jaguars -110, Bears -11044.5
New Orleans Saints vs. Tampa Bay BuccaneersSaints -2.5Saints -140, Buccaneers +12042
Washington Commanders vs. Baltimore RavensRavens -6.5Commanders +260, Ravens -33052.5
Arizona Cardinals vs. Green Bay PackersPackers -5Cardinals +195, Packers -24049.5
Indianapolis Colts vs. Tennessee TitansColts -1Colts -115, Titans -10543
Cleveland Browns vs. Philadelphia EaglesEagles -8.5Browns +260, Eagles -32543.5
Houston Texans vs. New England PatriotsTexans -7Texans -305, Patriots +24541
Los Angeles Chargers vs. Denver BroncosChargers -3Chargers -140, Broncos +11535.5
Pittsburgh Steelers vs. Las Vegas RaidersSteelers -3Steelers -160, Raiders +13036.5
Detroit Lions vs. Dallas CowboysLions -3Lions -160, Cowboys +13052.5
Atlanta Falcons vs. Carolina PanthersFalcons -6Falcons -160, Panthers +13547.5
Cincinnati Bengals vs. New York GiantsBengals -3.5Bengals -215, Giants +17549
Buffalo Bills vs. New York JetsBills -2.5Bills -125, Jets +10541

Thursday Night Football

49ers vs. Seahawks

The 49ers (2-3 straight up/2-3 against the spread) opened as -3 favorites in their Thursday Night Football matchup against the Seahawks (3-2 SU/1-3-1 ATS), down from the lookahead line of 49ers -5.

As of Tuesday afternoon, this line is up to -3.5 at DraftKings, with the 49ers accounting for 64% of the bets and 66% of the money on the spread.

The total for this game opened at 47 and is up to 47.5. At DraftKings, 42% of the bets and 51% of money had come in on the under as of Tuesday afternoon.

Both teams are coming off disappointing losses in Week 5 as heavy favorites that couldn’t close the deal.

The San Francisco 49ers odds have them favored on the road against their division rivals after a 24-23 loss at home to the Cardinals, who were seven-point underdogs in Week 5.

It was a similar story for Seattle in Week 5, as they lost 29-20 at home to the Giants, who were also seven-point underdogs. Seattle’s offensive line struggled to protect Geno Smith, who was sacked six times, while its defense gave up 420 passing yards.

Jaguars vs. Bears

The Bears (3-2 SU/3-1-1 ATS) opened as slim 1 favorites at home against the Jaguars (1-4 SU/2-3 ATS).

As of Tuesday afternoon, this line had moved to Bears -2.5, with Chicago seeing 75% of the bets and 84% of the money on the spread at DraftKings.

The total was up to 44.5 on Tuesday afternoon from where it opened at 42.5. At DraftKings, 60% of the bets and 65% of the money is on the over.

The Chicago Bears go into this game unbeaten at home after a 36-10 win over the Panthers in Week 5. After a slow start to the season, Chicago’s offense clicked on all cylinders, converting 24 first downs. Caleb Williams finished 20-of-29 for 304 passing yards and two touchdowns. The defense sacked Andy Dalton four times and forced three turnovers.

Jacksonville is finally in the win column after beating the Colts 37-34 in Week 5. Trevor Lawrence finished 28-of-34 for 371 yards, two touchdowns, and an interception, while the offense racked up 9.3 yards per play.

Buccaneers vs. Saints

The Saints (2-2 SU/3-1 ATS) opened as -2.5 favorites in this divisional matchup at home against the Buccaneers (3-2 SU/3-2 ATS).

This line was unchanged following the Saints’ 23-13 loss to the Chiefs on Monday Night Football. As of Tuesday afternoon, 62% of the bets and 87% of the money on the spread has come in on the Buccaneers at DraftKings.

The total is down to 42 after opening at 44.5. At DraftKings, 82% of the bets and 79% of the money are on the over.

Tampa Bay will be playing on extra rest after losing 36-30 in overtime to the Falcons on Thursday night. Despite its best efforts, the Buccaneers’ defense struggled to contain Kirk Cousins, who finished with 509 passing yards and four touchdowns.

Commanders vs. Ravens

The Baltimore Ravens (3-2 SU/3-2 ATS) opened as -6.5 favorites at home against the Commanders (4-1 SU/4-1 ATS). This line was unchanged as of Tuesday afternoon, with 73% of the bets and 54% of the money on the spread coming in on Washington at DraftKings.

The total opened at 49.5 and was quickly bet up to 52.5. At DraftKings, 69% of the bets and 88% of the money is on the over as of Tuesday afternoon. It is the highest total of the week and, so far, the only one above 50.

Baltimore survived a thrilling 41-38 shootout against the Bengals on Sunday, thanks to a game-winning field goal from Justin Tucker in overtime. The Ravens capitalized on a missed Bengals 53-yard attempt in overtime as Derrick Henry broke off a 51-yard run to set up the winning kick.

The Commanders tallied a commanding 34-13 win over the Browns last week, improving to 4-1 for the first time since 2008. Offensive Rookie of the Year favorite Jayden Daniels finished 14-of-25 for 238 passing yards and a touchdown, adding 82 rushing yards before resting in the fourth quarter with the game in hand. Washington’s defense racked up seven sacks and gave up just 212 total yards.

Cardinals vs. Packers

The Green Bay Packers (3-2 SU/3-2 ATS) are down to -5 favorites at home against the Cardinals (2-3 SU/3-2 ATS), after opening at -5.5.

At DraftKings, 45% of the bets and 60% of the money on the spread have come in on the Packers, as of Tuesday afternoon.

The total remains at 49.5 on Tuesday afternoon, with 55% of the bets and 53% of the money going toward the over at DraftKings.

Green Bay is coming off a 24-19 victory over the Rams in Week 5, led by the budding connection between Jordan Love and tight end Tucker Kraft. Kraft finished with four receptions for 88 yards and two touchdowns and has now accumulated three TDs and 141 receiving yards over his past two games.

The Cardinals, meanwhile, pulled off a dramatic 24-23 upset over the 49ers, beating their NFC West rival for the first time in their last five matchups. They overcame a 13-point deficit thanks to a rushing attack that averaged 6.5 yards per carry before their defense sealed the victory with a crucial interception late.

Colts vs. Titans

The Colts (2-3 SU/4-1 ATS) are opened as -1 favorites on the road against the Titans (1-3 SU/1-3 ATS), and that has not changed through Tuesday afternoon.

At DraftKings, 72% of the bets and 68% of the money on the spread have come in on the Colts.

The total is up to 43 after opening at 41.5, with 58% of the bets and 77% of the money coming in on the over at DraftKings, as of Tuesday afternoon.

The Colts suffered a 37-34 loss to the Jaguars last week despite backup quarterback Joe Flacco finishing 33-of-44 for 359 yards and three touchdowns. However, their defense faltered, allowing Trevor Lawrence to throw for 371 yards and two touchdowns. Indianapolis’ offense has performed much better with Anthony Richardson out with injury, a situation oddsmakers will continue to monitor throughout the week.

Tennessee secured its first win of the season with a Week 4 victory over the Dolphins. Nick Folk made five field goals, including three from over 50 yards. After Will Levis left early with a shoulder injury, backup Mason Rudolph came in and threw for 85 yards on 9-of-17 passing. Oddsmakers will be monitoring that situation throughout the week.

Browns vs. Eagles

The Eagles (2-2 SU/2-2 ATS) open as -8.5 favorites against the Browns (1-4 SU/1-4 ATS), a massive swing from the lookahead line of Eagles -3. That was unchanged as of Tuesday afternoon, with the Eagles drawing 56% of the bets and 62% of the money on the spread at DraftKings.

The total opened at 44 and is down to 43.5 as of Tuesday afternoon, with 52% of the bets and 57% of the money coming in on the over at DraftKings.

Philadelphia is looking to get right after enjoying one of the season’s first bye weeks. Injuries have plagued star receivers AJ Brown and DeVonta Smith through the first four weeks, and oddsmakers will be monitoring their status throughout the week.

The Browns are searching for momentum after another disappointing loss in Week 5, a 34-13 blowout to the Commanders. Their offense managed only 125 passing yards, and quarterback Deshaun Watson was sacked seven times.

Texans vs. Patriots

The Texans (4-1 SU/1-3-1 ATS) are up to -7 favorites against the Patriots (1-4 SU/1-3-1 ATS) on the road, up from where they opened at Texans -6.5. At DraftKings, Houston is drawing 91% of the bets and 82% of the money on the spread as of Tuesday afternoon.

The total is down to 37.5 after opening at 41, with the under attracting 37% of the bets and 82% of the money at DraftKings.

Houston is riding high on a four-game win streak and covered the spread for the first time this season with a 23-20 win over the Bills thanks to a last-second 59-yard field goal. C.J. Stroud threw for 244 yards but had two turnovers, while the Houston defense held Josh Allen to just 9-of-30 completions. Houston receiver Nico Collins left the game with a hamstring injury, a situation oddsmakers will be monitoring throughout the week.

New England allowed Miami a much-needed 15-10 win last week, failing to generate much of anything on offense once again and committing 105 yards worth of penalties. The Patriots are averaging just 12.5 points per game since upsetting the Bengals in Week 1.

Chargers vs. Broncos

The Chargers (2-2 SU/2-2 ATS) are -3 favorites on the road against the Broncos (1-4 SU/4-1 ATS). That was unchanged as of Tuesday afternoon, with the Chargers drawing 43% of the bets and 53% of the money on the spread at DraftKings.

The total is down to 35.5 after opening at 37, with the under accounting for 43% of the bets and 92% of the money at DraftKings.

Los Angeles was on a bye after a narrow loss in Week 4 to the Chiefs. After taking an early double-digit lead, the Chargers went scoreless through the last three quarters to lose 17-10.

Denver is riding a three-game winning streak after a 34-18 victory over Las Vegas in Week 5. Cornerback Patrick Surtain II led the way with two interceptions, including a 100-yard pick-six, while Denver’s offensive line allowed just three pressures. The Broncos’ offense put up the most points of the Bo Nix era. He finished 19-of-27 for 206 passing yards and two touchdowns.

Steelers vs. Raiders

The Steelers (3-2 SU/3-2 ATS) opened as -3 favorites on the road against the Raiders (2-3 SU/2-3 ATS). That was unchanged as of Tuesday afternoon, with the Steelers attracting 84% of the bets and 81% of the money on the spread at DraftKings.

The total is down to 36.5 after opening at 37.5, with the under accounting for 40% of the bets and 81% of the money at DraftKings.

Pittsburgh is coming off a last-minute 20-17 loss to the Cowboys, where Justin Fields struggled, finishing 22-of-34 for 131 passing yards and 55 rushing.

Las Vegas fell to the Broncos 34-10 on SundayGardner Minshew threw two interceptions before the team replaced him with Aidan O’Connell. He struggled without star receiver Davante Adams, who has been out while the team looks to honor his trade request. Oddsmakers will be monitoring both Adams’ and Minshew’s status going into this Week 5 matchup.

Lions vs. Cowboys

The Lions (3-1 SU/3-1 ATS) opened as -3 favorites on the road against the Cowboys (3-2 SU/2-3 ATS). That was unchanged as of Tuesday afternoon, with the Lions accounting for 77% of the bets and 91% of the money on the spread at DraftKings.

The total is 52.5, slightly up from 52 when it opened, with the over drawing 45% of the bets and 54% of the money at DraftKings.

The Lions are getting even more points after being on a bye week, while the Cowboys have flipped from favorites to home dogs after pulling off a last-minute upset against the Steelers. In their 20-17 victory, Dak Prescott threw for 352 yards and led a game-winning drive to overcome his three turnovers. A last-minute fourth-and-goal catch from Jalen Tolbert sealed the victory, despite a relatively quiet night for star receiver CeeDee Lamb.

Falcons vs. Panthers

The Falcons (3-2 SU/2-3 ATS) are up to -6 on the road against the Panthers (1-4 SU/1-4 ATS) as of Tuesday afternoon, after opening as -3 favorites. At DraftKings, the Falcons are drawing 89% of the bets and 90% of the money on the spread.

The total is at 47.5, up from where it opened at 45, with the under getting 45% of the bets and 80% of the money at DraftKings.

Atlanta secured a thrilling 36-30 overtime win against the Buccaneers in Week 5, highlighted by 500 passing yards and four touchdowns from Kirk Cousins. A game-tying field goal at the end of regulation set up a 45-yard touchdown to Khadarel Hodge on the first possession of overtime, lifting Atlanta above .500 for the first time this season.

Carolina, meanwhile is tied for the worst record in the league after a 36-10 loss at Chicago in Week 5, as quarterback Andy Dalton committed three turnovers and was sacked four times. The Panthers struggled to contain rookie quarterback Caleb Williams, who finished 20-of-29 for 304 passing yards and two touchdowns.

Sunday Night Football

Bengals vs. Giants

The Bengals (1-4 SU/2-3 ATS) are down to -3.5 on the road against the Giants (2-3 SU/3-2 ATS) as of Tuesday afternoon, a point from where this opened at Bengals -4.5. At DraftKings, the Bengals are drawing 79% of the bets and 84% of the money on the spread.

The total is up to 49 after opening at 46.5, with the over drawing 59% of the bets and 68% of the money at DraftKings.

Cincinnati is coming off another heartbreaking loss, this one by a score of 41-38 in overtime to the Ravens in Week 5. Despite Joe Burrow throwing for a career-high five touchdowns, the Bengals missed a 53-yard field goal in overtime after recovering a fumble near midfield. Baltimore secured the win with a field goal of its own.

Meanwhile, the Giants pulled off a 29-20 road upset in Seattle, covering as seven-point underdogs. Daniel Jones led the offense with key contributions from rookie running back Tyrone Tracy Jr., who rushed for 129 yards, and wide receiver Darius Slayton, who made several contested catches. On defense, New York’s trio of Brian Burns, Dexter Lawrence, and Kayvon Thibodeaux combined for six sacks.

Monday Night Football

Bills vs. Jets

The Bills (3-2 SU/2-3 ATS) are up to -2.5 favorites in this Monday Night Football matchup against the Jets (2-3 SU/2-3 ATS), as of Tuesday afternoon, up from where this opened at Bills -2.

At DraftKings, the Bills are accounting for 79% of the bets and 80% of the money on the spread.

The total line is 41, down from where it opened at 44, with the under attracting 35% of the bets and 60% of the money at DraftKings.

Buffalo is looking to bounce back after a tough 23-20 loss to the Texans in Week 5. Despite erasing a 17-point deficit, the Bills couldn’t hold on, and Josh Allen struggled, finishing just 9-of-30 amid constant pressure from Houston’s defense. He was briefly checked for a concussion but returned and is expected to play in this Week 6 matchup.

The Jets, also on a two-game losing streak, suffered a 23-17 loss to the Vikings in London. Aaron Rodgers finished 29-of-54 for 244 yards and two touchdowns but threw three interceptions, including one that sealed the game during its final minutes.

NFL Week 6 odds tracker

MatchupCurrent SpreadOpening Spread
San Francisco 49ers vs. Seattle Seahawks49ers San Francisco 49ers -3.5 on Bet36549ers -3
Jacksonville Jaguars vs. Chicago BearsBears Chicago Bears +1.5 on Bet365Bears -1
New Orleans Saints vs. Tampa Bay BuccaneersSaints New Orleans Saints +3.5 on CaesarsSaints -2.5
Washington Commanders vs. Baltimore RavensRavens Baltimore Ravens -7 on BetRiversRavens -6.5
Arizona Cardinals vs. Green Bay PackersPackers Green Bay Packers -5.5 on BetRiversPackers -5.5
Indianapolis Colts vs. Tennessee TitansColts Indianapolis Colts +2.5 on BetRiversColts -1
Cleveland Browns vs. Philadelphia EaglesEagles Philadelphia Eagles -8 on DraftKingsEagles -7
Houston Texans vs. New England PatriotsTexans Houston Texans -6.5 on BetRiversTexans -6.5
Las Angeles Chargers vs. Denver BroncosChargers Los Angeles Chargers -3 on BetRiversChargers -3
Pittsburgh Steelers vs. Las Vegas RaidersSteelers Pittsburgh Steelers -3 on BetRiversSteelers -3
Detroit Lions vs. Dallas CowboysLions Detroit Lions -3.5 on BetRiversLions -3
Atlanta Falcons vs. Carolina PanthersFalcons Atlanta Falcons -6 on CaesarsFalcons -3
Cincinnati Bengals vs. New York GiantsBengals Cincinnati Bengals -4 on Bet365Bengals -4.5
Buffalo Bills vs. New York JetsBills Buffalo Bills -1 on BetRiversBills -2
Photo by Associated Press/Nick Wass