The San Francisco 49ers’ Week 6 odds have the team at -3.5 on the point spread for a road game versus the Seattle Seahawks on Thursday Night Football. San Francisco is coming off an upset loss to the Cardinals at home and is at -170 on the moneyline. The 49ers’ 2025 Super Bowl odds dipped slightly this week to +800.
San Francisco 49ers Week 6 odds
Below, you can find the latest NFL lines for upcoming 49ers games — including their Week 6 matchup with the Seahawks — as the odds become available at online sportsbooks.
49ers Week 6 player props
49ers player props for the team’s Week 6 matchup with the Seahawks appear below. You can use the bet finder tool to search for players and bets for every upcoming NFL game.
San Francisco 49ers odds to win the Super Bowl
Last update: October 2024
When NFL betting sites released Super Bowl 59 odds in January, the 49ers were at +500. San Francisco’s current odds to win the 2025 Super Bowl are San Francisco 49ers +700 on BetRivers.
San Francisco 49ers win total odds
San Francisco 49ers futures odds for 2024-25
Here’s a look at the latest 49ers futures odds for the upcoming season. We cover odds to win the NFC, make the playoffs, and more.
| 49ers futures | Current odds |
|---|---|
| Win total | 11.5 (-155) on Consensus |
| To make the playoffs | Yes -285 on DraftKings |
| To win the NFC West | San Francisco 49ers -180 on Bet365 |
| To win the NFC | San Francisco 49ers +360 on FanDuel |
| To finish in the top two of the NFC West | San Francisco 49ers -10000 on Consensus |
| To have the best regular season record | San Francisco 49ers +4000 on DraftKings |
California betting resources
Looking for options beyond betting on the 49ers? Below are resources available to California bettors.
Current 49ers sportsbook promotions
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San Francisco 49ers 2024 schedule
| Away team | Home team | Date & time | Location |
|---|---|---|---|
| Jets (+6.5) | 49ers (-6.5) | 9/9, 8:20 p.m. ET | Levi’s Stadium |
| 49ers (-6) | Vikings (+6) | 9/15, 1 p.m. ET | U.S. Bank Stadium |
| 49ers (-2.5) | Rams (+2.5) | 9/22, 4:25 p.m. ET | SoFi Stadium |
| Patriots (+11.5) | 49ers (-11.5) | 9/29, 4:05 p.m. ET | Levi’s Stadium |
| Cardinals (+9.5) | 49ers (-9.5) | 10/6, 4:05 p.m. ET | Levi’s Stadium |
| 49ers (-4) | Seahawks (+4) | 10/10, 8:15 p.m. ET | Lumen Field |
| Chiefs (+2) | 49ers (-2) | 10/20, 4:25 p.m. ET | Levi’s Stadium |
| Cowboys (+4.5) | 49ers (-4.5) | 10/27, 8:20 p.m. ET | Levi’s Stadium |
| 49ers (-4) | Buccaneers (+4) | 11/10, 1 p.m. ET | Raymond James Stadium |
| Seahawks (+9) | 49ers (-9) | 11/17, 4:05 p.m. ET | Levi’s Stadium |
| 49ers (-2.5) | Packers (+2.5) | 11/24, 4:25 p.m. ET | Lambeau Field |
| 49ers (-2) | Bills (+2) | 12/1, 8:20 p.m. ET | Highmark Stadium |
| Bears (+5.5) | 49ers (-5.5) | 12/8, 4:25 p.m. ET | Levi’s Stadium |
| Rams (+6.5) | 49ers (-6.5) | 12/12, 8:15 p.m. ET | Levi’s Stadium |
| 49ers (-1) | Dolphins (+1) | 12/22, 4:25 p.m. ET | Hard Rock Stadium |
| Lions (+4.5) | 49ers (-4.5) | 12/30, 8:15 p.m. ET | Levi’s Stadium |
| 49ers (-5.5) | Cardinals (+5.5) | 1/5, TBD | State Farm Stadium |
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San Francisco 49ers FAQ
San Francisco went 9-11 ATS in the 2023-24 season.
The team released DT Arik Armstead but added other help on the defensive line, including Maliek Collins, Yetur Gross-Matos, and Jordan Elliott.
Brock Purdy returned as QB1 after leading the team to a conference title in his first full season under center for San Francisco.