NFL Week 1 Odds: Latest Spreads, Moneylines, Totals

Week 1 of the NFL regular season is underway. The Buffalo Bills made a statement with a big victory over the defending champion Los Angeles Rams on Thursday night, cementing their status as Super Bowl favorites in the process.

The opening week wraps up with Monday Night Football as Russell Wilson leads the Denver Broncos to take on the Seattle Seahawks. In between is a busy Sunday slate, including a potential revenge spot for Baker Mayfield as the Carolina Panthers welcome the Cleveland Browns to town.

Sportsbooks have betting lines available for all of the Week 1 matchups. Let’s take a look at what’s on tap and the latest numbers, followed by the key storylines to watch for each game.

NFL Week 1 odds: Spread, moneyline and totals

The odds board has been active for NFL Week 1. Four of the 15 remaining games currently have spreads set at a field goal or less, and there are a whopping 9 home underdogs. One spread has hit as low as a pick’em, while another reached 8.5 before falling slightly. Totals have been ranging from the low 40s to 50+ points. Below is a real-time look at the latest Week 1 lines from the top sportsbooks.

Week 1 NFL betting lines and schedule

The full Week 1 schedule is listed down below with the latest pregame betting lines from DraftKings Sportsbook. Across the slate, several games are expected to be tight, while others have clear favorites. It’s a similar story on scoring as a few contests are anticipated to be on the light side with others projecting to be potential shootouts.

*NFL Week 1 betting odds via DraftKings Sportsbook

Last updated: Sept. 10, 2022

NFL Week 1 Betting Breakdown

The opening week of the NFL regular season is filled with appealing matchups. Here’s a quick breakdown of all of the games along with the best available spread odds.

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Tampa Bay Buccaneers () at Dallas Cowboys () – 8:20 p.m. ET

These two squads hooked up in Week 1 last year in Tampa Bay. The result was a 31-29 win for the Buccaneers, but the Cowboys easily covered as nine-point road underdogs. Dallas is the dog once again, but this time on its home field.

It’s a quality opener for this year’s Sunday Night Football schedule, and the spread should be one of the more interesting to watch for movement. Cowboys WR Michael Gallup will miss the opener due to injury, while Bucs wideout Chris Godwin is questionable.

Indianapolis Colts () at Houston Texans () – 1 p.m. ET

Matt Ryan is the latest veteran signal-caller to get the nod in Indianapolis. He had his struggles in Atlanta last year, but the same was true for the rest of the team. Ryan joins a squad that heads toward the season as the market favorite to win the AFC South. The Colts defense is legit, while Jonathan Taylor is a wrecking ball out of the backfield.

As for the Texans, the team has finally moved on from Deshaun Watson as the rebuild continues. Lovie Smith has his work cut out in his first year on the Houston sidelines. For Indianapolis, star defender Shaquille Leonard will miss this game due to injury.

Pittsburgh Steelers () at Cincinnati Bengals () – 1 p.m. ET

Times are changing in the AFC North. The Bengals are the defending division champs and are fresh off a surprising Super Bowl berth. Joe Burrow and Ja’marr Chase are a dynamic duo on offense, while the defense seemed to keep getting better last season.

In Pittsburgh, the retirement of Ben Roethlisberger opens the door to a new era. Mitchell Trubisky will be the QB1 in Week 1 after a preseason battle with rookie Kenny Pickett. A year after a playoff berth, the Steelers have the look of a team with work to do in the AFC North.

Baltimore Ravens () at New York Jets () – 1 p.m. ET

Plenty of kudos have gone to the Ravens for what looks like a solid haul at the NFL Draft. Last year, the Ravens went from AFC frontrunner at 8-3 to one that missed the playoffs at 8-9 following a major rash of injuries. RB JK Dobbins could miss this one, meaning that it could be a RB committee for Baltimore.

Meanwhile, the Jets were a disaster in 2021, but the hope is that they’ll take a step forward in year two. If not, it could be back to the drawing board once again in the Big Apple. Zach Wilson was injured during the preseason and will miss some time. Veteran QB Joe Flacco will get the start and square off against his former team.

Philadelphia Eagles () at Detroit Lions () – 1 p.m ET

A lot of love has been heading in the direction of Philadelphia. The trade for A.J. Brown has certainly helped to bolster enthusiasm, as Jalen Hurts suddenly has another weapon at his disposal.

Over in Detroit, there were growing pains for first-year head coach Dan Campbell and company a season ago, but the club did show some fight under his watch. Notable improvement could finally be in the cards for long-suffering Lions fans.

New Orleans Saints () at Atlanta Falcons () – 1 p.m. ET

A year after QB Drew Brees hung up his cleats for good, head coach Sean Payton joined him. Dennis Allen is the new head coach for a team that still has the talent to contend in what looks like a wide-open NFC.

There are questions in Atlanta as Arthur Smith enters his second season as head coach. The team shipped Matt Ryan off to the Colts, so it’s now Marcus Mariota as QB1. The offense looks like a potential trouble spot for the Falcons.

San Francisco 49ers () at Chicago Bears () – 1 p.m. ET

After coming up short in last year’s NFC title game, the 49ers were expected to trade Jimmy Garoppolo and hand the reins to Trey Lance. Garoppolo, though, is still in town for a team that could contend once again, but Lance is locked in at QB1. For the opener, TE George Kittle is questionable.

The Bears failed to impress during the offseason. While there’s optimism that Justin Fields could finally be the answer at QB, there’s just not a lot of talent for him to lean on. Much to the chagrin of Chicago fans, the Bears could be in a battle for the NFC North basement.

Jacksonville Jaguars () at Washington Commanders () – 1 p.m. ET

Change is in the air in both cities as we head toward the new season. Doug Pederson, the former Super Bowl-winning coach of the Eagles, is now leading the way in Jacksonville. He’s tasked with putting the pieces back together after a trying season under Urban Meyer.

The brief Carson Wentz era is over in Indianapolis and he’s now penciled in as the starter for a Commanders team that closed out last year at 7-10. There’s talent on both sides of the ball in Washington, so we’ll see if head coach Ron Rivera can get over the hump in year three.

New England Patriots () at Miami Dolphins () – 1 p.m. ET

This AFC East battle is a meeting of two clubs whose expectations are heading in opposite directions. The Patriots looked great at times last season, but a quick exit in the playoffs and a questionable offseason of moves have led to some head-scratching in New England.

Down in Miami, the party appears to be just getting started. The team traded for speedster Tyreek Hill to further bolster its offense. The stage is set for Tua Tagovailoa to take a leap forward. Whether he does so will be one of 2022’s more interesting stories to watch.

Cleveland Browns () at Carolina Panthers () – 1 p.m. ET

The award for offseason drama seems like a lock for Cleveland. The team swung a trade for Deshaun Watson, while a messy breakup with former first overall draft pick Baker Mayfield has led to him being traded to the Panthers, the team they’ll be facing in Week 1. Watson is suspended for the first 11 games of the season.

The potential revenge game narrative should dominate the news cycle in the days leading up to kickoff. Opening odds for this game had the Browns as a slight road favorite, but the numbers have shifted in the wake of Watson’s suspension. Jacoby Brissett will be behind center for Cleveland.

New York Giants () at Tennessee Titans () – 4:25 p.m. ET

New GM Joe Schoen and head coach Brian Daboll, both formerly of Buffalo, face the task of righting the ship for a Giants team that hasn’t been to the playoffs since 2016. The club got some high marks after the NFL Draft, so fortunes could be improving. Rookie defender Kayvon Thibodeaux is doubtful for this game.

The Titans have been to the postseason three years in a row. They could end up battling it out with the Colts for the AFC South crown. The trade of A.J. Brown has opened up some questions about the potency of the offense, but top RB Derrick Henry is expected to be back at full speed.

Green Bay Packers () at Minnesota Vikings () – 4:25 p.m. ET

The Packers have had the run of the NFC North for the last three years. Aaron Rodgers will be back to try for his third straight NFL MVP award, but the clock is ticking on his quest for a second Super Bowl ring in Green Bay. Allen Lazard, projected to be a top Packers passing game target, is doubtful for this game.

Minnesota is another team with a new head coach for 2022. The offense could improve under new head coach Kevin O’Connell, formerly the offensive coordinator of the Rams.

Las Vegas Raiders () at Los Angeles Chargers () – 4:25 p.m. ET

The AFC West appears poised to be ultra-competitive this season. The three clubs that have been playing catch-up with the Chiefs all made big improvements in the offseason. For the Raiders, new head coach Josh McDaniels could get more out of the offense, and the team’s trade for Davante Adams made that even more likely.

The Chargers’ defense, meanwhile, could take a leap forward following the addition of Khalil Mack. For the opener, CB JC Jackson is doubtful. It might only be Week 1, but this could prove to be a pivotal game in the division standings once the season is in the books.

Kansas City Chiefs () at Arizona Cardinals () – 4:25 p.m. ET

There’s still plenty of time for movement, but this game currently checks in with the highest total of Week 1. We could see some fireworks in the desert as a result, but the changing casts on both sides suggest that the offenses may need some time to gel.

Among the notable moves, Tyreek Hill is on to Miami from Kansas City, while Marquise Brown is now in Arizona following a trade from the Ravens. Regardless of who is catching the ball, Patrick Mahomes and Kyler Murray could put on a show. Star Arizona defender JJ Watt could miss the game

Denver Broncos () at Seattle Seahawks () – 8:15 p.m. ET

For the final game of Week 1, the schedule makers once again demonstrate a flair for the dramatic. One of the offseason’s biggest stories was the trade of Russell Wilson from the Seahawks to the Broncos. The story continues on Monday Night Football.

Geno Smith has been installed as the starter in Seattle. Denver has quickly moved up odds boards with Wilson’s addition, while the Seahawks appear to be taking a step back. It looks like a great way to close out the opening week and kick off MNF.

Thursday, Sept. 8

Buffalo Bills 31, Los Angeles Rams 10

The preseason favorite in Super Bowl futures odds went to Los Angeles and made a statement. The Bills picked up a huge double-digit victory, easily covering the 2.5-point spread while the total sailed well under the over/under of 52 points. Current MVP betting favorite Josh Allen also lived up to the hype, while the defending champion Rams just couldn’t get into gear. It’s only Week 1, but Buffalo is looking awfully dangerous.