NFL Week 1 Odds: Latest Spreads, Moneylines, Totals

Written By Christopher Feery on June 28, 2022 - Last Updated on July 4, 2022
NFL Week 1 odds

Week 1 of the NFL regular season gets underway with what looks like a stellar matchup on Thursday, Sept. 8. It’s a potential Super Bowl preview as the Buffalo Bills hit the road to take on the defending champion Los Angeles Rams.

The first week comes to a close with an intriguing edition of Monday Night Football. It’ll be a homecoming of sorts for Russell Wilson as he leads the Denver Broncos to his old stomping grounds to take on the Seattle Seahawks. In between the two bookend games is a jam-packed Sunday of NFL action with 14 games.

Sportsbooks have released odds for all of the Week 1 matchups. Let’s take a look at what’s on tap and the latest numbers, followed by the key storylines to watch for each game.

NFL Week 1 odds: Spread, moneyline and totals

Odds for NFL Week 1 are available for betting. Five of the 16 games currently have spreads set at a field goal or less. The season opener is the lowest with the Rams as a slight 1-point favorite over the Bills, while the largest has the Colts favored by 7.5 over the Texans. As for totals, the Chiefs vs. Cardinals is the largest at 53 points, while the Broncos vs. Seahawks is the smallest at 41. Below is a real-time look at the latest numbers from all of the top sportsbooks.

Week 1 NFL betting lines and schedule

DateSpreadMoneylineOver/Under
Thursday, Sept. 8Bills @ Rams
(-1)
Bills -110
Rams -110
O/U 52.0
Sunday, Sept. 11Eagles
(-4) @ Lions
Eagles -190
Lions +160
O/U
46.5
Sunday, Sept. 11Ravens
(-4.5) @ Jets
Ravens -195
Jets +165
O/U
45.0
Sunday, Sept. 11Jaguars @ Commanders (-4)Jaguars +160
Commanders -190
O/U
44.5
Sunday, Sept. 1149ers
(-6.5) @ Bears
49ers -275
Bears +220
O/U
42.5
Sunday, Sept. 11Saints
(-3.5) @ Falcons
Saints -180
Falcons +155
O/U
42.0
Sunday, Sept. 11Colts
(-7.5) @ Texans
Colts -380
Texans +290
O/U
44.5
Sunday, Sept. 11Bengals
(-6.5) @ Bengals
Steelers +200
Bengals -250
O/U
45.0
Sunday, Sept. 11Patriots @ Dolphins
(-3)
Patriots +135
Dolphins -155
O/U
45.0
Sunday, Sept. 11Browns
(-3.5) @ Panthers
Browns -180
Panthers +155
O/U
42.5
Sunday, Sept. 11Giants @ Titans
(-6.5)
Giants +235
Titans -300
O/U
44.0
Sunday, Sept. 11Chiefs
(-3) @ Cardinals
Chiefs -150
Cardinals +130
O/U
53.0
Sunday, Sept. 11Raiders @ Chargers
(-4)
Raiders +155
Chargers -180
O/U
52.0
Sunday, Sept. 11Packers
(-1.5) @ Vikings
Packers -120
Vikings +100
O/U
49.0
Sunday, Sept. 11Buccaneers
(-2.5) @ Cowboys
Buccaneers -135 Cowboys +115O/U
51.5
Monday, Sept. 12Broncos
(-4) @ Seahawks
Broncos -190
Seahawks +160
O/U
41.0

*NFL Week 1 betting odds via DraftKings Sportsbook

Thursday, Sept. 8

Buffalo Bills at Los Angeles Rams (-1) – 8:20 p.m. ET

If we look at the current Super Bowl futures odds, the Bills are the top choice on the board, while the defending champion Rams are not too far away. Said another way, the NFL season could begin and end with the same exact matchup.

The Buffalo offense remains potent with Josh Allen at the helm, while the defense got a lift with the signing of Von Miller. Los Angeles is loaded once again, and the chemistry between Matthew Stafford and all-world wideout Cooper Kupp should only improve in year two.

Sunday, Sept. 11

Tampa Bay Buccaneers (-2.5) at Dallas Cowboys – 8:20 p.m. ET

These two squads hooked up in Week 1 last year in Tampa Bay. The result was a 31-29 win for the Buccaneers, but the Cowboys easily covered as nine-point road underdogs. Dallas is the dog once again, but this time on its home field.

It’s a quality opener for this year’s Sunday Night Football schedule, and the spread should be one of the more interesting to watch as Week 1 approaches. Tampa Bay is the current favorite to win the NFC, while Dallas is the fifth choice in the futures market.

Philadelphia Eagles (-4) at Detroit Lions – 1 p.m ET

It’s a little early to start christening preseason darlings, but a lot of love has been heading in the direction of Philadelphia. The trade for A.J. Brown has certainly helped to bolster enthusiasm, as Jalen Hurts suddenly has another weapon at his disposal.

Over in Detroit, there were growing pains for first-year head coach Dan Campbell and company a season ago, but the club did show some fight under his watch. Notable improvement could finally be in the cards for long-suffering Lions fans.

Baltimore Ravens (-5) at New York Jets – 1 p.m. ET

Plenty of kudos have gone to the Ravens for what looks like a solid haul at the NFL Draft. Last year, the Ravens went from AFC frontrunner at 8-3 to one that missed the playoffs at 8-9 after a major rash of injuries.

Meanwhile, the Jets were a disaster in 2021, but the hope is that Zach Wilson will fare better in year two. If not, it could be back to the drawing board once again in the Big Apple.

Jacksonville Jaguars at Washington Commanders (-4) – 1 p.m. ET

Change is in the air in both cities as we head toward the new season. Doug Pederson, the former Super Bowl-winning coach of the Eagles, is now leading the way in Jacksonville. He’s tasked with putting the pieces back together after a trying season under Urban Meyer.

The brief Carson Wentz era is over in Indianapolis and he’s now penciled in as the starter for a Commanders team that closed out last year at 7-10. There’s talent on both sides of the ball in Washington, so we’ll see if head coach Ron Rivera can get over the hump in year three.

San Francisco 49ers (-6.5) at Chicago Bears – 1 p.m. ET

After coming up short in last year’s NFC title game, the 49ers were expected to trade Jimmy Garoppolo and hand the reins to Trey Lance. Garoppolo, though, is still in town for a team that could contend once again, but we can consider this a fluid situation that’s subject to change.

The Bears failed to impress during the offseason. While there’s optimism that Justin Fields could finally be the answer at QB, there’s just not a lot of talent for him to lean on. Much to the chagrin of Chicago fans, the Bears could be in a battle for the NFC North basement.

New Orleans Saints (-4.5) at Atlanta Falcons – 1 p.m. ET

A year after QB Drew Brees hung up his cleats for good, head coach Sean Payton joined him. Dennis Allen is the new head coach for a team that still has talent to contend in what looks like a wide-open NFC.

There are questions in Atlanta as Arthur Smith enters his second season as head coach. The team shipped Matt Ryan off to the Colts, so it’s now Marcus Mariota as QB1. Barring any additional moves, the offense looks like a trouble spot for the Falcons.

Indianapolis Colts (-7.5) at Houston Texans – 1 p.m. ET

Matt Ryan is the latest veteran signal-caller to get the nod in Indianapolis. He had his struggles in Atlanta last year, but the same was true for the rest of the team. Ryan joins a team that heads toward the season as the market favorite to win the AFC South. The Colts’ defense is legit, while Jonathan Taylor is a wrecking ball out of the backfield.

As for the Texans, the team has finally moved on from Deshaun Watson as the rebuild continues. Lovie Smith has his work cut out in his first year on the Houston sidelines.

Pittsburgh Steelers at Cincinnati Bengals (-6.5) – 1 p.m. ET

Times are changing in the AFC North. The Bengals are the defending division champs and are fresh off a surprising Super Bowl berth. Joe Burrow and Ja’marr Chase are a dynamic duo on offense, while the defense seemed to keep getting better last season.

In Pittsburgh, the retirement of Ben Roethlisberger opens the door to a new era. Mitchell Trubisky and rookie Kenny Pickett will likely be battling in camp for the starting QB gig. A year after a playoff berth, the Steelers have the look of a team with work to do in the AFC North.

New England Patriots at Miami Dolphins (-3) – 1 p.m. ET

This AFC East battle is a meeting of two clubs whose expectations are heading in opposite directions. The Patriots looked great at times last season, but a quick exit in the playoffs and a questionable offseason of coaching moves have led to some head-scratching in New England.

Down in Miami, the party appears to be just getting started. The team traded for speedster Tyreek Hill to further bolster its offense. The stage is set for Tua Tagovailoa to take a leap forward. Whether he does so will be one of 2022’s more interesting stories to watch.

Cleveland Browns at Carolina Panthers – 1 p.m. ET

The award for offseason drama seems like a lock for Cleveland. The team swung a trade for Deshaun Watson and his legal troubles, which appears to portend a messy breakup with former first overall draft pick Baker Mayfield, who is still in town. Opening odds for this game are on hold until we have further clarity on Watson’s status.

After somewhat promising starts, the 2021 season ended in disappointment for both the Browns and Panthers. On paper, Cleveland appears to be in better overall shape and will likely be favored for this contest.

New York Giants at Tennessee Titans (-6.5) – 4:25 p.m. ET

New GM Joe Schoen and head coach Brian Daboll, both formerly of Buffalo, face the task of righting the ship for a Giants team that hasn’t been to the playoffs since 2016. The club got some high marks after the NFL Draft, so fortunes could be improving.

The Titans have been to the postseason three years in a row. They could end up battling it out with the Colts for the AFC South crown, but the trade of A.J. Brown has opened up some questions about the potency of the offense that regains top RB Derrick Henry from injury.

Kansas City Chiefs (-3) at Arizona Cardinals – 4:25 p.m. ET

There’s still plenty of time for movement, but this game currently checks in with the highest total of Week 1 at 53 points. We could see some fireworks in the desert as a result, but the changing casts on both sides suggest that the offenses may need some time to gel.

Among the notable moves, Tyreek Hill is on to Miami from Kansas City, while Marquise Brown is now in Arizona following a draft day trade from the Ravens. Regardless of who is catching the ball, Patrick Mahomes and Kyler Murray could put on a show.

Las Vegas Raiders at Los Angeles Chargers (-4) – 4:25 p.m. ET

The AFC West appears poised to be ultra-competitive this season. The three clubs that have been playing catch-up with the Chiefs all made big improvements in the offseason. For the Raiders, new head coach Josh McDaniels could get more out of the offense, and the team’s trade for Davante Adams made that even more likely.

The Chargers’ defense, meanwhile, could take a leap forward following the addition of Khalil Mack. It might only be Week 1, but this could prove to be a pivotal game in the division standings once the season is in the books.

Green Bay Packers (-1.5) at Minnesota Vikings – 4:25 p.m. ET

The Packers have had the run of the NFC North for three years running. Aaron Rodgers will be back to try for his third straight NFL MVP award, but the clock is ticking on his quest for a second Super Bowl ring in Green Bay.

Minnesota is another team with a new head coach for 2022. The offense could improve under new head coach Kevin O’Connell, formerly the offensive coordinator of the Rams.

Monday, Sept. 12

Denver Broncos (-4) at Seattle Seahawks – 8:15 p.m. ET

For the final game of Week 1, the schedule makers once again demonstrate a flair for the dramatic. One of the offseason’s biggest stories was the trade of Russell Wilson from the Seahawks to the Broncos. The story continues on Monday Night Football.

Denver has quickly moved up odds boards with Wilson’s addition, while the Seahawks appear to be taking a step back. It looks like a great way to close out the opening week and kick off MNF.

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Christopher Feery

Christopher has been writing professionally for several years, covering sports for multiple outlets along the way. Following the legalization of sports betting in New Jersey in 2018, the industry quickly became his sole content focus. He contributes analysis, guides, and reviews to Legal Sports Report and other sites within the Catena Media network.

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