Buffalo Bills’ Week 5 odds have them at +1.5 on the spread for a road game versus the Houston Texans. Buffalo is 3-1 on the season following a loss to the Ravens. Houston improved to 3-1 with a comeback win over the Jaguars on Sunday. The Bills are at +1000 in 2025 Super Bowl odds this week.
Buffalo Bills Week 5 odds
Below, you can find the latest NFL lines for upcoming Bills games — including their Week 5 showdown with the Texans — as they become available at online sportsbooks.
Bills Week 5 player props
Bills player props for the team’s Week 5 matchup with the Texans will appear below once they are available at NFL sportsbooks. Clicking on a bet that you’d like to place will take you to the sportsbook offering that wager.
Buffalo Bills odds to win the Super Bowl
Last updated: October 2024
When Super Bowl 59 odds came out at NFL betting sites in January, the Bills’ line was +900. The Bills’ current odds to win the 2025 Super Bowl are .
Buffalo Bills win total odds
Buffalo Bills futures odds for 2024
Here’s a look at the latest Bills futures odds for the upcoming season.
| Bills futures | Current odds |
| To win the AFC | |
| To win the AFC East | |
| Top two in AFC East | |
| To have the best regular season record | |
| To make the playoffs |
Current Bills sportsbook promotions
GET $100
Bills 2024 schedule
| Away team | Home team | Date & time | Location |
|---|---|---|---|
| Cardinals (+7) | Bills (-7) | 9/8, 1 p.m. ET | Highmark Stadium |
| Bills (+2.5) | Dolphins (-2.5) | 9/12, 8:15 p.m. ET | Hard Rock Stadium |
| Jaguars (+4.5) | Bills (-4.5) | 9/23, 7:30 p.m. ET | Highmark Stadium |
| Bills (+3) | Ravens (-3) | 9/29, 8:20 p.m. ET | M&T Bank Stadium |
| Bills (+1.5) | Texans (-1.5) | 10/6, 1 p.m. ET | NRG Stadium |
| Bills (+1) | Jets (-1) | 10/14, 8:15 p.m. ET | MetLife Stadium |
| Titans (+7) | Bills (-7) | 10/20, 1 p.m. ET | Highmark Stadium |
| Bills (-2) | Seahawks (+2) | 10/27, 4:05 p.m. ET | Lumen Field |
| Dolphins (+3) | Bills (-3) | 11/3, 1 p.m. ET | Highmark Stadium |
| Bills (-2) | Colts (+2) | 11/10, 1 p.m. ET | Lucas Oil Stadium |
| Chiefs (-1) | Bills (+1) | 11/17, 4:25 p.m. ET | Highmark Stadium |
| 49ers (-2) | Bills (+2) | 12/1, 8:20 p.m. ET | Highmark Stadium |
| Bills (-1) | Rams (+1) | 12/8, 4:25 p.m. ET | SoFi Stadium |
| Bills (+2) | Lions (-2) | 12/15, 4:25 p.m. ET | Ford Field |
| Patriots (+7.5) | Bills (-7.5) | 12/22, 1 p.m. ET | Highmark Stadium |
| Jets (+2.5) | Bills (-2.5) | 12/29, 1 p.m. ET | Highmark Stadium |
| Bills (-3.5) | Patriots (+3.5) | 1/5, TBD | Gillette Stadium |
Upcoming games
Other NFL teams
American Football Conference
National Football Conference
Buffalo Bills FAQ
The Bills are among the AFC favorites to win the 2025 Super Bowl. At the initial release of Super Bowl 59 futures odds, the club was the third team on the board, behind only the 49ers and Chiefs.
The Bills were 8-11 against the spread last season, including the postseason. The team went 12-7 on the moneyline and 8-11 on the over/under.
The Bills signed Curtis Samuel during free agency. Stefon Diggs is among the players who have moved on from Buffalo. The team’s first pick at the NFL Draft was WR Keon Coleman.
Josh Allen signed a six-year contract extension with the Bills in August 2021. The total value is over $258 million. Allen was a first-round pick in the 2018 NFL Draft, and the extension will keep him in Buffalo at least through the 2028 season.