College Football Week 6 Odds: Spreads, Moneylines, & Totals For Key Games

College football Week 6 odds are available at online sportsbooks. The week continues with a handful of games on Friday night, followed by a marathon Saturday of action.  

Top matchups at college football betting sites include Missouri vs. Texas A&M in an SEC showdown. Clemson will visit Florida State in ACC action, and Michigan will be on the road for a Big 10 date with Washington.

Down below, we take a complete look at Week 6 games and the latest odds at legal online sports betting sites.

College football Week 6 odds: Spreads, moneylines, totals

College football Week 6 spreads, lines, totals

College football Week 6 odds and analysis 

Missouri vs. Texas A&M

• Spread: Missouri , Texas A&M
• Moneyline: Missouri , Texas A&M
• Over/under:

It’s SEC action as Missouri travels to take on Texas A&M. Last time out, 4-0 Missouri received a scare from visiting Vanderbilt, escaping with a 30-27 win in double overtime. Texas A&M has ripped off four straight wins since a loss to Notre Dame in its opener. On Saturday, the Aggies defeated visiting Arkansas, 21-17.  

Clemson vs. Florida State

• Spread: Clemson , Florida State
• Moneyline: Clemson , Florida State
• Over/under:

Heading into the season, Florida State was favored to win the ACC in college football conference odds. A 1-4 start for the Seminoles has upended the board, with Miami now on top. Clemson, 3-1 following a 40-14 win over Stanford, is second in the latest lines. Florida State took last season’s meeting of these squads, 31-24 in overtime. 

Iowa vs. Ohio State

• Spread: Iowa , Ohio State
• Moneyline: Iowa , Ohio State
• Over/under:

Ohio State has taken over as the betting favorite in College Football Playoff odds to win the national title. The Buckeyes are 4-0 following a 38-7 win over Michigan State. Iowa is 3-1 after a 31-14 road win over Minnesota. Ohio State has won six of its last seven games against the Hawkeyes, most recently with a 54-10 thrashing.  

Michigan vs. Washington

• Spread: Michigan , Washington
• Moneyline: Michigan , Washington
• Over/under:

Defending national champion Michigan has rebounded from a loss to visiting Texas by winning three straight. Last time out, it was a 27-24 win over visiting Minnesota. Washington is 3-2, losing at Rutgers last Friday night by a score of 21-18. This is a rematch of last season’s national championship game, a 34-13 victory for the Wolverines. 

Michigan State at Oregon

• Spread: Michigan State , Oregon
• Moneyline: Michigan State , Oregon
• Over/under:

Michigan State dropped to 3-2 with a 38-7 loss to Ohio State on Saturday, the team’s second straight defeat. The Ducks are 4-0 following a 34-13 win over UCLA. Oregon has won its last two games by double digits after opening the campaign with a pair of close wins. This will be the first meeting of the two programs since 2018, a 7-6 win for Oregon.

Ole Miss at South Carolina

• Spread: Ole Miss , South Carolina
• Moneyline: Ole Miss , South Carolina
• Over/under:

Ole Miss dropped to 4-1 with a loss to Kentucky on Saturday. The Rebels walked onto the field as a -15.5 home favorite, but the Wildcats managed to exit with a 20-17 upset win. South Carolina, meanwhile, is 3-1, most recently defeating visiting Akron 50-7. Ole Miss took the last meeting of these two schools in 2020 by a score of 59-42.

Auburn at Georgia

• Spread: Auburn , Georgia
• Moneyline: Auburn , Georgia
• Over/under:

Auburn fell to 2-3 with a 27-21 loss to visiting Oklahoma on Saturday, the team’s second consecutive defeat. Georgia is 3-1 following a 41-34 loss to Alabama. The Bulldogs were down 30-7 at the half and rallied to close the deficit after the break but ultimately came up short. Georgia has won seven straight over the Tigers, taking last season’s meeting by a score of 27-20.

Alabama at Vanderbilt

• Spread: Alabama , Vanderbilt
• Moneyline: Alabama , Vanderbilt
• Over/under:

Alabama remains perfect on the season after a 41-34 win over visiting Georgia on Saturday. Jalen Milroe has taken over as the betting favorite in Heisman Trophy odds. He threw for two touchdowns and rushed for another two in the winning effort. Vanderbilt is 2-2, losing to Missouri last time out, 30-27 in double overtime. The Commodores are 3-1 against the spread so far this season.

USC at Minnesota

• Spread: USC , Minnesota
• Moneyline: USC , Minnesota
• Over/under:

USC is 3-1 following a 38-21 win over Wisconsin, rebounding from a tough road loss at Michigan. Minnesota dropped to 2-3 with a 27-24 loss to the Wolverines on Saturday. The Golden Gophers covered the spread as +10.5 road dogs. This will be the first meeting of the teams since 2011, a 19-17 victory for USC.

Miami at Cal

• Spread: Miami , Cal
• Moneyline: Miami , Cal
• Over/under:

Miami is 5-0 following a 38-34 win over Virginia Tech, missing the cover as a hefty -17.5 home favorite. Cameron Ward threw for 343 yards, four TDs, and two interceptions in the winning effort. Cal had last week off and is 3-1 on the season. The Golden Bears dropped a 14-9 road decision to Florida State last time out.

College football Week 6 odds tracker