NFL Week 6 Odds: Current Point Spreads, Moneylines, And Totals

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The NFL regular season is headed into Week 6, and top online sportsbooks have released full betting odds on every upcoming game. The action begins on Sunday morning, when the Baltimore Ravens (-4) take on the Tennessee Titans in the NFL’s last London game of the season.

Later on Sunday, the unbeaten San Francisco 49ers will hit the road to take on the underdog Cleveland Browns (+10.5) in a game where the line has continued to climb on reports that the Browns will likely be without QB Deshaun Watson again. The Miami Dolphins will be without star rookie RB De’Von Achane due to a knee injury, but they are still (-13.5) favorites at home against the winless Carolina Panthers. Week 6 wraps up with the New York Giants (+14.5) at the Buffalo Bills on Sunday Night Football, followed by the Los Angeles Chargers hosting the Dallas Cowboys (-2) on Monday Night Football.

Below, you’ll find all the latest odds, point spreads, and more for every upcoming NFL game in Week 6 of the regular season.

NFL Week 6 point spreads

NFL Week 6 moneyline odds

NFL Week 6 over/under lines

Week 6 player props

Use the table below to sort through the prop bets for every NFL game in Week 6. Just type the name of any player into the search field and you’ll see the prop bet options available for that player from multiple online sportsbooks.

Today’s Sportsbook Offers in Virginia

Steelers, Dolphins, Bears, Lions All Win


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get more NFL betting info

There are more ways to bet on the NFL beyond the spreads and totals in Week 6. Learn about the best football betting apps — with welcome bonuses for new customers — or check out some different NFL odds. Below is a selection of options:

NFL Week 6 betting matchups

Washington Commanders at Atlanta Falcons

Sunday, 1 p.m. ET, CBS 

The Washington Commanders lost their third straight game, dropping to 2-3 with a 40-20 loss to the Bears on Thursday night. QB Sam Howell threw for 388 yards and two TDs with one interception, but the Commanders’ defense surrendered 359 yards and four touchdowns through the air. Washington is dealing with a rash of injuries, adding three players to the IR on Thursday, with nine other players either inactive or questionable for Week 6.

The Atlanta Falcons improved to 3-2 after a last-second field goal gave the team a 21-19 win over the Texans on Sunday. QB Desmond Ridder threw for a career-high 329 yards and one TD while also running in another touchdown. RB Bijan Robinson was held to 46 yards on 14 carries, and the Falcons lost two fumbles on the day. T Kaleb McGeary left the game with a knee injury and is questionable for Week 6. The club has acquired WR Van Jefferson via trade with the Rams for a conditional draft pick.

Minnesota Vikings at Chicago Bears

Sunday, 1 p.m. ET, Fox

The Minnesota Vikings are 1-4 after dropping a 27-20 loss at home against the Chiefs on Sunday. Kirk Cousins threw for 284 yards with two TDs, but WR Justin Jefferson left the game with a hamstring injury after three catches for 28 yards. The Vikings have placed him on injured reserve, and he will miss at least the next four games. CB Akayleb Evans also left the game due to a knee injury and did not return.

The Chicago Bears got their first win of the season on Thursday night, beating the Commanders 40-20 on the road. WR D.J. Moore had three receiving TDs and 230 yards on eight receptions. Chicago will be missing three running backs, with Roschon Johnson, Khalil Herbert, and Travis Homer all ruled out this week. The club has signed RB Darrynton Evans from the Dolphins’ practice squad. Chicago has a total of 10 players who sat out practice on Wednesday.

Seattle Seahawks at Cincinnati Bengals

Sunday, 1 p.m. ET, CBS

The Seattle Seahawks had a bye in Week 5. The team is 3-1 after a 24-3 win over the Giants on Monday Night Football in Week 4. QB Geno Smith is questionable with a knee issue. CB Artie Burns is also questionable with a hamstring injury, as is CB Tre Brown, who is in the league’s concussion protocol. CB Jamal Adams remains in the protocol and is in the final stages of being cleared. WR DK Metcalf is expected to play but was kept out of practice with an ongoing rib issue.

The Cincinnati Bengals improved to 2-3 with a road win over the Cardinals on Sunday, 34-20. Joe Burrow rebounded after several disappointing weeks to throw for 317 yards with three TDs and one interception. WR Ja’Marr Chase caught all three of those touchdowns, finishing with 15 receptions for 192 yards on the day. WR Tee Higgins was inactive for the game with a rib issue but was back at practice in a limited fashion this week.

San Francisco 49ers at Cleveland Browns

Sunday, 1 p.m. ET, Fox 

The San Francisco 49ers remained undefeated with a 42-10 win over the Cowboys at home on Sunday night to improve to 5-0 on the season. Brock Purdy threw for 252 yards and four TDs, three of which were hauled in by TE George Kittle. RB Christian McCaffrey added another touchdown while running for 51 yards, and the defense managed four sacks and four turnovers. G Aaron Banks left the game with a biceps injury, and his status for Week 6 is still unclear. C Jon Feliciano has been cleared from concussion protocol and is available to play.

The Cleveland Browns are 2-2 and coming off a bye in Week 5. QB Deshaun Watson did not play in the team’s last game, a 28-3 loss at home against the Steelers in which replacement QB Dorian Thompson-Robinson was picked off three times. The point spread has continued to widen on news that Watson is still dealing with a shoulder injury and has not practiced this week. Backup QB PJ Walker is expected to get the start if Watson is unable to play. DE Myles Garrett is also questionable as he deals with a foot issue, as is C Ethan Pocic with a knee injury.

Carolina Panthers at Miami Dolphins

Sunday, 1 p.m. ET, CBS

The Carolina Panthers are the NFL’s only remaining winless team after a 42-24 loss on the road against the Lions on Sunday. Rookie QB Bryce Young threw for 247 yards with three TDs but also two picks as the team fell to 0-5. WR Adam Thielen led the team with 107 receiving yards and one touchdown. Rookie offensive lineman Chandler Zavala had to leave the field after being down and motionless for several minutes, but he reportedly has movement in his extremities after being transported to a hospital. Cade Mays came in to replace Zavala at left guard. RB Miles Sanders sat out Wednesday’s practice due to a shoulder injury.

The Miami Dolphins bounced back from their first loss of the season to improve to 4-1 with a 31-16 win over the Giants at home on Sunday. QB Tua Tagovailoa threw for 308 yards with two TDs and two interceptions. RB De’Von Achane had another big outing, running for 151 yards and one touchdown, but he suffered a knee injury and will miss at least four games on injured reserve. WR Tyreek Hill caught eight passes for 186 yards and one TD. LB Jaelan Phillips continues to struggle with an oblique issue and missed his second straight game, but he could return for Week 6. RB Jeff Wilson Jr. has been activated from IR and now has a 21-day practice window open.

Indianapolis Colts at Jacksonville Jaguars

Sunday, 1 p.m. ET, CBS

The Indianapolis Colts improved to 3-2 with a 23-16 win at home against the Titans on Sunday but lost rookie QB Anthony Richardson to a shoulder injury in the first half. Gardner Minshew stepped in after Richardson left and threw for 155 yards with no TDs or interceptions in the win. The Colts placed Richardson on IR with an AC joint sprain. He’ll miss at least the next four games, potentially more. The club has signed QB Kellen Mond to the practice squad. RB Zack Moss ran for 167 yards and two touchdowns on Sunday. The Colts agreed to a contract extension with RB Jonathan Taylor, who saw limited time last week with that workload expected to increase moving forward.

The Jacksonville Jaguars won their second straight game in London, pulling off an upset to beat the Bills 25-20 on Sunday. Trevor Lawrence threw for 315 yards with one TD, while Travis Etienne ran for 136 yards with two scores. WR Zay Jones was questionable for this game with a knee injury but ended up playing and left in the second half and is day-to-day. T Walker Little also left early after being questionable with a knee injury. Neither has a definite status for Week 6.

New Orleans Saints at Houston Texans

Sunday, 1 p.m. ET, Fox

The New Orleans Saints moved to 3-0 with a 34-0 blowout of the Patriots on Sunday. QB Derek Carr threw for 183 yards and two TDs, and RB Alvin Kamara added 80 rushing yards and one touchdown on the ground. The New Orleans defense had three takeaways while holding New England to 45 rushing yards in the game. DB J.T. Gray left the game with a hamstring issue and is questionable for Week 6, as is FB Adam Prentice, who left with a knee injury.

The Houston Texans lost on a last-second field goal against the Falcons on the road last week, dropping to 2-3 on the season. CJ Stroud threw for 249 yards with one TD, and Dameon Pierce managed 66 yards on 20 carries. WR Tank Dell took a hard hit late in the first half and left the game to receive concussion evaluation. He’s now in the protocol and questionable for Sunday’s game. WR Robert Woods also left the game with a rib issue.

New England Patriots at Las Vegas Raiders

Sunday, 4:05 p.m. ET, CBS 

The New England Patriots fell to 1-4 with a 34-0 loss at home against the Saints on Sunday. QB Mac Jones threw two interceptions before being spelled by Bailey Zappe, who went 3-of-9 for 22 yards. Jones is expected to get the start this week. Receivers Juju Smith-Schuster and Demario Douglas both exited this game with head injuries and did not practice this week while in the concussion protocol.

The Las Vegas Raiders moved to 2-3 on the season with a 17-13 victory over the Packers on Monday night. Jimmy Garoppolo returned to the starting QB role after missing last week and threw for 208 yards with one TD and one interception. WR Davante Adams played despite a shoulder injury, catching four passes for 45 yards. WR Tre Tucker left the game with a knee injury and is questionable for Week 6. Cornerbacks Nate Hobbs and Jakorian Bennett missed Monday’s game with injuries, and Las Vegas has already ruled them out for Sunday’s game, as well.

Arizona Cardinals at Los Angeles Rams

Sunday, 4:25 p.m. ET, Fox 

The Arizona Cardinals slipped to 1-4 with a 34-20 home loss against the Bengals on Sunday. QB Joshua Dobbs threw for 166 yards with two TDs but also two picks. The Cardinals surrendered three turnovers in the game. RB James Conner left the game with an apparent knee injury and was added to the IR this week, with an expected return of Week 10. RB Emari Demarcado gained 57 total yards and ran for a score after taking over in the backfield. CB Antonio Hamilton was evaluated for a concussion in the game but was cleared. RB Keaontay Ingram is questionable with a neck issue.

The Los Angeles Rams fell to 2-3 with a 24-14 loss at home on Sunday against the unbeaten Eagles. Matthew Stafford threw for 196 yards and two TDs. WR Cooper Kupp returned to the lineup and led the team in receiving yards, catching eight passes for 118 yards. The Rams were missing G Joe Noteboom and T Andrew Thomas for this game and struggled some with pass protection, giving up four sacks. Neither yet has a clear status for Week 6. The team has traded WR Van Jefferson to the Falcons for a conditional draft pick.

Philadelphia Eagles at New York Jets 

Sunday, 4:25 p.m. ET, Fox

The Philadelphia Eagles are still undefeated, moving to 5-0 with a 23-14 win on the road against the Rams on Sunday. Jalen Hurts threw for 303 yards with one TD and ran for 72 yards with another TD. WR A.J. Brown hauled in six passes for 127 yards. The Eagles’ defense largely shut the Rams down in the second half, holding Los Angeles to 54 rushing yards on the game and finishing with four sacks. DT Fletcher Cox was inactive with a back issue, but the team reportedly is hopeful he could be healthy enough to return in Week 6. LB Nakobe Dean has been designated to return from IR and now has a 21-day practice window.

The New York Jets got their second win of the season on the road against the Broncos last week, winning 31-21 to improve to 2-3. Zach Wilson threw for 198 yards and one interception, while RB Breece Hall picked up 177 yards rushing with one touchdown on the ground. The New York defense came up big late, returning a fumble for a TD to shut the door in the fourth quarter. G Alijah Vera-Tucker had to leave the game with a knee injury and is questionable.

Detroit Lions at Tampa Bay Buccaneers

Sunday, 4:25 p.m. ET, Fox

The Detroit Lions improved to 4-1 after beating the Panthers at home on Sunday, 42-24. Jared Goff threw for 236 yards and three TDs, while adding another on the ground. RB David Montgomery had another big game, running for 109 yards and one touchdown. DB Emmanuel Moseley and RB Zonovan Knight both left this game with injuries and are questionable for Week 6. WR Amon-Ra St. Brown missed last week with an abdominal injury. He returned to practice on Wednesday, however. RB Jahmyr Gibbs is day-to-day after missing last week due to a hamstring injury.

The Tampa Bay Buccaneers are 3-1 and coming off a bye in Week 5. The team beat the Saints 26-9 in its last game, with QB Baker Mayfield throwing for 246 yards, three TDs and one interception. Tampa Bay added four defensive players to the questionable list for this game last Monday, including LB SirVocea Dennis, who’s still dealing with a hamstring issue. S Ryan Neal is still in the NFL’s concussion protocol. WR Mike Evans has missed practice time due to a hamstring injury and is questionable.

New York Giants at Buffalo Bills 

Sunday Night Football, 8:20 p.m. ET, NBC

The New York Giants are off to a 1-4 start after losing a third straight game, going down 31-16 on the road against the Dolphins on Sunday. QB Daniel Jones was 14-of-20 passing with 119 yards before leaving the game with an apparent neck injury. His 2021 season ended with a similar neck injury, but this one is said to be different and Jones says he expects to play this week. Tyrod Taylor came on in relief last week and threw for 86 yards with six completions on nine attempts. RB Saquon Barkley practiced in a limited fashion on Wednesday, but doesn’t yet have a definite status for Week 6. TE Darren Waller also sat out Wednesday’s practice with a groin injury.

The Buffalo Bills fell to 3-2 on the season with a loss Sunday in London against the Jaguars, 25-20. Buffalo looked lackluster and jet-lagged as the offense struggled to get going until the fourth quarter. QB Josh Allen finished with 359 yards through the air with two TDs and one interception. TE Dalton Kincaid suffered a concussion and is now in the protocol. Injuries hampered the Bills’ defense, and in this game LB Matt Milano went down with a leg injury and could be done for the season. DE DaQuan Jones was questionable for the game and ended up leaving briefly but returning. The Bills had a total of five defensive players inactive for Sunday’s game.

Dallas Cowboys at Los Angeles Chargers

Monday Night Football, 8:15 p.m. ET, ABC, ESPN

The Dallas Cowboys dropped to 3-2 after a lopsided loss on the road Sunday night, falling to the 49ers by a score of 42-10. San Francisco picked Dak Prescott off three times — he threw for 153 yards with one TD — and held RB Tony Pollard to 29 yards on eight carries. Dallas managed just 197 yards of total offense while giving up 421 total yards. WR KaVontae Turpin suffered an ankle injury in the first half and didn’t return. LB Leighton Vander Esch left the game late with a neck injury, and CB C.J. Goodwin left with a shoulder issue. Their availability for Week 6 isn’t yet clear.

The Los Angeles Chargers had a bye in Week 5 after improving to 2-2 with a 24-17 win over the Raiders in their last game. QB Justin Herbert threw for 167 yards with one TD and one interception in that victory but dealt with a finger issue that has him on the questionable list for this game. RB Austin Ekeler is also questionable with an ankle injury, but he is aiming to make his return after missing the last three games. LB Joey Bosa is questionable with a hamstring problem.