Week 16 NFL Odds: Opening Spreads, Moneylines, Totals

The NFL Week 16 schedule features a variety of marquee matchups with postseason implications. LSR offers the latest odds from top sportsbooks along with a quick-hitting NFL betting preview for Week 16 games.

NFL Week 16 odds: Spreads, moneylines, totals

NFL Week 16 opening spreads, lines, totals

NFL Week 16 game odds and analysis

Denver Broncos (+3) at Los Angeles Chargers (-3)

The Broncos handled their business at home against the Colts in Week 15 with a 31-13 victory that didn’t exactly start out in the most positive fashion. However, Denver’s defense did bounce back after getting trounced by Jameis Winston and Jerry Jeudy in Week 13 before the bye. Bo Nix could have a second consecutive difficult challenge against the Bolts after throwing three picks Sunday.

The Chargers could be an ornery bunch in this divisional clash after getting embarrassed at home by the Buccaneers, 40-17. Justin Herbert got Ladd McConkey back and played well, but it was the team’s typically standout defense that shockingly let it down, both through the air and on the ground.

The Broncos are an impressive 4-1 ATS as road underdogs this season, while the Chargers hold the same record as home favorites. The two teams are also each 3-1 ATS in division games.

The game has opened with an over/under of 42.5 points.

Houston Texans (-2.5) at Kansas City Chiefs (+2.5)

This already intriguing late-season Saturday matchup just became a lot more interesting due to an ankle injury to Patrick Mahomes late in Sunday’s win over the Browns. Houston has moved to as much as a 2.5-point favorite for the moment at some sportsbooks, despite a fairly ugly win against the Dolphins in Week 15.

The Kansas City Chiefs actually put together a more comfortable win than usual against the Browns, but Mahomes was trapped under two defenders late in the fourth quarter and saw Carson Wentz finish the game out for him. His status will naturally be one to closely monitor this week as KC looks to ensure Buffalo doesn’t catch up for the top seed.

The Texans are 1-1 ATS in the rare instances they’ve been road underdogs this season, while the Chiefs, given their penchant for close games, are unsurprisingly just 2-5 against the number as home favorites.

This game opened with an over/under of 41.5 points.

Pittsburgh Steelers (+6.5) at Baltimore Ravens (-6.5)

The Steelers came up short in a tough interconference intrastate battle against the Eagles on Sunday, falling by a score of 27-13. Pittsburgh played its second straight game without George Pickens (hamstring), leaving Russell Wilson notably undermanned against Philly’s defense.

The Baltimore Ravens, meanwhile, dominated the Giants on the road as expected, forging a 35-14 win in which Lamar Jackson took center stage with five touchdown passes. Impressive as the performance was, it essentially doesn’t move the needle on the perception of John Harbaugh’s squad, which usually has no trouble trampling inferior competition.

The Steelers, who will be without Pickens again, are an impressive 3-1 ATS this season as road dogs and hold the same mark in all their division games. In turn, the Ravens are a respective 2-3-1 and 1-3 ATS in those respective splits.

This game opened with an over/under of 46.5 points.

Cleveland Browns (+7) at Cincinnati Bengals (-7)

The Browns couldn’t give a Chiefs team that had struggled to separate from any opponent much trouble, as they fell by a 21-7 score to the defending champs. Jameis Winston also earned himself a benching by throwing three interceptions, but head coach Kevin Stefanski won’t yet commit to the veterar or second-year signal-caller Dorian Thompson-Robinson for this matchup.

The Bengals took care of the Titans by a 37-27 score on the road. Cincy has won two straight and remains in the outer boundary of the AFC playoff picture at 6-8. The team has a drastic dichotomy, as the offense is essentially Super Bowl-caliber while the defense is anything but. 

The game has opened with an over/under of 48.0 points.

New York Giants (+10) at Atlanta Falcons (-10)

The Giants continued their countdown to the end of a lost season with a 35-14 loss to the Ravens at MetLife Stadium. New York’s pass defense, which had held up fairly well despite the team’s struggles, allowed Lamar Jackson to throw for five TDs. Meanwhile, Tommy DeVito suffered a concussion that will potentially sideline him for this game, which could leave Tim Boyle as the starter if Drew Lock can’t recover from his heel injury.

The Falcons are battling the Raiders on Monday Night Football in Week 15 in an attempt to get to 7-7 and keep their hopes of catching the Buccaneers in the NFC South. Kirk Cousins is trying to bounce back from a four-game stretch so bad that it may have him in danger of losing his job to rookie Michael Penix. 

The game has opened with an over/under of 42.5 points.

Philadelphia Eagles (-4) at Washington Commanders (+4)

The Philadelphia Eagles took care of business against a talented and feisty opponent in the Steelers on Sunday, recording a 27-13 win. Philly is now 12-2 and has drawn even with the Lions, which took their second loss of the season Sunday at the hands of the juggernaut Bills. Jalen Hurts was able to get the passing game going against Pittsburgh to an appreciable degree, and he’ll look to lead a season sweep of Washington in this road battle.

The Commanders got more of a fight than they likely bargained for from the Saints on Sunday before escaping with a 20-19 win in New Orleans when Darren Rizzi opted to go for a would-be game-winning two-point conversion attempt. Washington has had some good late-game fortune this season but now faces a much tougher test as it looks to keep its playoff position secure.

This game opened with an over/under of 46.5 points.

Detroit Lions (-7) at Chicago Bears (+7)

The Lions finally lost again and did so in the most prominent way possible, falling to the Bills by a 48-42 score in what could well prove to be the game of the season. In essence, Detroit played the role of Buffalo in their own Week 14 loss to the Rams, as the Lions fell behind early and then almost pulled off a comeback. Yet, even more important than the final score was the fact David Montgomery has been lost for the rest of the season due to an MCL injury.

The Bears are battling another NFC North rival in the Vikings on Monday Night Football and appear firmly on the way to another loss. Chicago’s offense is compiling some impressive numbers under Thomas Brown’s stewardship, but the wins still aren’t coming and are resulting in lines like the one for this game, despite the fact it’s taking place at Soldier Field.

The game has opened with an over/under of 46.5 points.

Tennessee Titans (+4.5) at Indianapolis Colts (-4.5)

The Titans had their moments against the Joe Burrow and the Bengals on Sunday, but Tennessee head coach Brian Callahan ultimately couldn’t beat his former protege. Tony Pollard also appears to be significantly hobbled by his ankle injury near the end of the game and saw Tyjae Spears put some great play on film in his place, so perhaps a changing of the guard for the last portion of the season might be in play, considering the team’s lack of postseason aspirations.

The Colts have plenty of problems of their own, beginning with the team’s most important position. Anthony Richardson once again completed under 50.0 percent of his passes and also threw two more interceptions without a passing TD and continues to cast doubt about his long-term fit for the job.

The game has opened with an over/under of 42.5 points.

Arizona Cardinals (-4) at Carolina Panthers (+4)

The Cardinals secured a very necessary win over the Patriots on Sunday, that while expected, was nevertheless critical for a team that got back to .500 at 7-7. The Cards are still a game back of both the Rams and Seahawks in the NFC West, but if James Conner can replicate his 110-yard, two-touchdown rushing performance versus the league’s most generous run defense in this spot, Arizona should have a strong chance at a win.

The Panthers couldn’t live up to their rare home-favorite status against the Cowboys, falling by a 30-14 score. Bryce Young had a bit of regression against an aggressive defense that sacked him six times and picked him off twice. However, the second-year signal-caller still looks much more competent than earlier in the season and could have his chances against this consistent defense.

The game has opened with an over/under of 47 points.

Los Angeles Rams (-3) at New York Jets (+3)

The Rams pushed to 8-6 and the top of the NFC West with their ugly but clutch 12-6 win over the 49ers on Thursday night to open Week 15. Los Angeles’ Big Three was much quieter than in the win against Buffalo four days earlier – in fact, Cooper Kupp went without a catch for the first time since 2019 – but Sean McVay’s squad has worked itself into a real shot at the division crown.

The Jets have no postseason aspirations, but New York played with plenty of fight and finally snapped its marathon losing streak with a 32-25 win over the Jaguars. Aaron Rodgers went from an utterly forgettable first half to turning back the clock for a second straight week in the second half and helping Davante Adams to a 9-198-2 line along the way.

The game has opened with an over/under of 46.5 points.

Minnesota Vikings (-2.5) at Seattle Seahawks (+2.5)

Minnesota will host the Bears on Monday night looking to improve its record to 12-2 and draw into a three-way tie with the Eagles and Lions for the best record in the NFC.

The Seattle Seahawks, meanwhile, lost to the visiting Packers on Sunday Night Football. Seattle came into the game running hot with four straight wins that vaulted it to first place in the NFC West, but the loss to Green Bay puts it in a tie with the Rams. 

The Vikings are 2-2-1 ATS as road favorites this season and have yet to play with a rest disadvantage. The Seahawks are just 1-4 ATS as a home underdog.

This game opened with an over/under of 45 points.

New England Patriots (+14) at Buffalo Bills (-14)

The Patriots came out of the bye with another loss, falling by a 30-17 score to the Cardinals despite another serviceable performance by Drake Maye and Rhamondre Stevenson. New England’s run defense was once again a primary culprit in the team’s downfall by allowing a big game on the ground to James Conner, and the imagination soars when projecting what Josh Allen and co. might be able to accomplish in this spot.

Speaking of the Bills’ juggernaut attack, it delivered a second straight performance of more than 40 points against the Lions on the road in Week 15. Allen continues to look like the runaway MVP winner, while James Cook offered a reminder that he’s still a force to be reckoned with via his 100-yard effort and pair of rush TDs. 

The Patriots are 3-4 ATS as a road underdog this season and the Bills check in with a 4-2 mark against the number as a home favorite. The two clubs are 1-3 and 2-1, respectively, against the spread in division games.

The game has opened with an over/under of 46.5 points.

Jacksonville Jaguars (+1) at Las Vegas Raiders (-1)

The Jaguars continued to play feisty football in Week 15 but ultimately fell to the Jets and a revitalized Aaron Rodgers-Davante Adams connection. Nevertheless, Mac Jones once again impressed with 294 yards and two touchdowns, albeit alongside two INTs. Rookie WR Brian Thomas was on the receiving end of both scores and the two appear to be developing some encouraging chemistry down the stretch of an otherwise lost season.

Las Vegas took another loss on Monday night in Week 15, dropping a 15-9 decision to the Falcons. Las Vegas had to go with Desmond Ridder at quarterback, and although he turned in a serviceable performance, he tossed an interception on a last-second desperation heave to seal yet another defeat.

The Jaguars are 4-2 ATS as a road team this season, while the Raiders are 2-3-1 against the number at home. Vegas is also notably 2-0 ATS when playing with a rest disadvantage.

The game has opened with an over/under of 40.0 points.

San Francisco 49ers (+2.5) at Miami Dolphins (-2.5)

The 49ers took another stumble on Thursday Night Football to open Week 15, losing to the Rams by an ugly 12-6 score in which Brock Purdy completed well under 50% of his passes. San Fran is now 6-8 and looking for answers while running out of time in terms of staying in the NFC postseason picture. Isaac Guerendo should have some valuable time to heal up ahead of this matchup given the extra days between games.

The Miami Dolphins are essentially in the same boat as the Niners in the AFC. Like their opponent, they opened the season with Super Bowl aspirations and now sit at 6-8 following their loss to the Texans in Week 15. Moreover, Jaylen Waddle suffered a knee injury in the game that could well keep him out of this key contest.

The 49ers is just 1-5 ATS on the road this season, while the Dolphins are only 2-5 against the number at home. The teams are 2-2 and 1-3 ATS, respectively, in non-conference games.

This game opened with an over/under of 46.5 points.

Tampa Bay Buccaneers (-4.5) at Dallas Cowboys (+4.5)

The Buccaneers were part of what may have been the most surprising outcome of Week 15, as they throttled what had been a very stingy Chargers defense across the country on their home field. The quartet of Baker Mayfield, Bucky Irving, Mike Evans and Jalen McMillan were clicking on all cylinders in the 40-17 win and kept Tampa Bay right in the thick of the hunt for the NFC South crown.

The Cowboys were able to get another win in their own right, staying alive mathematically in the NFC wild-card race with a 30-14 road victory over the Panthers. Micah Parsons and the rest of the defense were in good form with six sacks and two picks while Cooper Rush authored the first three-TD game of his career. Given the weapons on either side in this matchup, the total could continue climbing throughout the week.

The Buccaneers are 2-1 ATS on the road this season, while the Cowboys are 0-5 versus the number as a home underdog and just 1-6 straight up with an ATS +/- of -15 points at home overall.

The game has opened with an over/under of 49 points.

New Orleans Saints (+13.5) at Green Bay Packers (-13.5)

The Saints didn’t let the Jake Haener experiment linger too long when it clearly wasn’t working. Interim coach Darren Rizzi turned to Spencer Rattler in the second half and got much better results, with the rookie nearly leading New Orleans all the way back from a 20-0 deficit against the Commanders. However, Alvin Kamara suffered an adductor injury that could sideline him for this prime-time battle.

The Packers were efficient and impressive in handling their business against the Seahawks on the road in Week 15. Green Bay rode a balanced offensive effort and impressive work on the defensive side of the ball to its 10th win and is in the driver’s seat for the top NFC wild-card spot entering this seemingly easy matchup.

The Saints are 2-2 ATS as road underdogs this season, while the Packers are 3-2 against the number as home favorites.

The game has opened with an over/under of 42 points.