Thursday Night Football Odds

Thursday Night Football in Week 1 will see the San Francisco 49ers take on the Los Angeles Rams on September 10. Interestingly, this year the Week 1 TNF game isn’t the first of the season, as the night before there will be a Wednesday game featuring a Super Bowl rematch between the Seattle Seahawks and the New England Patriots. There’s another first-week TNF twist this year, too, as the 49ers-Rams game will be the first NFL game ever in Melbourne, Australia.

Read on for the latest betting lines on the upcoming Thursday Night Football game, plus a recap of how teams performed against the spread and on totals throughout last season’s Thursday Night Football schedule.

TNF betting odds: 49ers vs. Rams

Here are the latest Thursday Night Football betting odds for the Week 1 matchup between the San Francisco 49ers and Los Angeles Rams:

Thursday Night Football odds: San Francisco 49ers vs. Los Angeles Rams

This NFC West clash is a huge early-season test with potential playoff implications. Last year, these two rivals split the season series, with San Francisco winning 26-23 in an OT thriller in October, and the Rams getting revenge in November by a 42-26 score.

The Rams come into Week 1 as the Super Bowl betting favorite by a decent margin over all other teams. QB Matthew Stafford is also a favorite to win another MVP award this year, as expectations are high following last year’s run to the NFC Championship game. All eyes will be on defensive end Myles Garrett and wide receiver Puka Nacua to help Stafford lead the Rams this season.

Meanwhile, the 49ers are hoping to make it through a full season without the devastating injuries that have plagued them of late. That will mean keeping QB Brock Purdy protected throughout the year, and also important contributors like George Kittle (TE), Trent Williams (OT), Fred Warner (LB), and Nick Bosa (DE) on the field.

2026 Thursday Night Football schedule

The complete Thursday Night Football schedule for 2026-27 season is below:

Other ways to bet on Thursday Night Football

As you dig deeper into how to bet on the NFL and the Thursday Night Football betting menu, you’ll find a host of other options. Here’s a look at some of the other ways to bet on the first game of the NFL week.

• Single-game parlays: You can place multi-leg wagers just for the TNF game. For example, you could wager on the over/under on total points and a favorite prop or two. The odds will depend on the selections you add to your slip, and you must get all your picks right to win.
• In-game betting: You can wager in real time as the TNF game plays out. Live betting opens as soon as the game kicks off and can keep going until the final whistle blows. You’ll see updated odds and wagers throughout the game, including options for spreads, totals, props, quarters, and halves.
• Alternate lines: If you’re not happy with the main pregame spreads and totals, sportsbooks offer alternate lines where you can give or take additional points. The odds will shift based on the number that you choose, as alternate lines give you the option of taking on more safety or risk for your bets.

Beyond betting on TNF on a standalone basis, you can also use the game as a starting point for multi-game parlays. For example, you could tie together the moneyline outcome with other bets from the full Sunday slate or Monday Night Football.

Best sportsbook promos for NFL Thursday Night odds

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Thursday Night Football FAQ