Thursday Night Football in Week 6 is an NFC West matchup between the San Francisco 49ers and the Seattle Seahawks. The 49ers are 3.5-point favorites on the point spread coming off Sunday’s upset loss. The Seahawks are at +160 on the moneyline for this home game.
Read on for the latest betting lines on the 49ers vs. Seahawks game on Thursday, plus a recap of how teams performed against the spread and on totals throughout last season’s Thursday Night Football schedule.
TNF betting odds: 49ers at Seahawks
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Thursday Night Football odds: San Francisco 49ers at Seattle Seahawks
- Spread: 49ers San Francisco 49ers -3.5 on FanDuel, Seahawks Seattle Seahawks +4 on BetRivers
- Moneyline: 49ers San Francisco 49ers -195 on BetRivers, Seahawks Seattle Seahawks +172 on FanDuel
- Total: 52.5 on FanDuel
The San Francisco 49ers fell to 2-3 on the season with a 24-23 upset loss at home against the Arizona Cardinals on Sunday. QB Brock Purdy threw two interceptions, and the offense committed three turnovers in the game. TE George Kittle was limited in practice this week but has been cleared for Thursday’s game. SS Talanoa Hufanga has been added to the IR, with George Odum stepping up in his place. DT Jordan Elliott and LB Demetrius Flannigan-Fowles are both out this week.
The Seattle Seahawks slipped to 3-2 with a 29-20 home loss to the New York Giants on Sunday. QB Geno Smith finished with 284 yards passing and another 72 yards rushing. LB Derek Hall nabbed a sack but left the game with a foot injury and is questionable for Thursday night’s game. CB Tariq Woolen is out this week.
Head To Head
Last Updated on 10.10.2024| STATS | 
49ers
SF | 
Seahawks
SEA |
|---|---|---|
| Offense Ranking OFF RNK | 2nd | 7th |
| Defense Ranking DEF RNK | 11th | 18th |
| Offense Net Yards Per Game OFF NET YPG | 420 | 373.2 |
| Defense Net Yards Per Game DEF NET YPG | 316.2 | 339.7 |
| Passing Yards Per Game PASS YPG | 262 | 276.7 |
| Turnovers Committed Per Game TOC PG | 1.3 | 1.7 |
2024 Thursday Night Football schedule
The complete Thursday Night Football schedule for 2024 is below.
| Week | Date | Matchup | Time (ET) | TV |
| 1 | Sept. 5 | Kansas City Chiefs 27, Baltimore Ravens 20 | 8:20 p.m. ET | NBC |
| 2 | Sept. 12 | Buffalo Bills 31, Miami Dolphins 10 | 8:15 p.m. ET | Prime |
| 3 | Sept. 19 | New York Jets 24, New England Patriots 3 | 8:15 p.m. ET | Prime |
| 4 | Sept. 26 | Dallas Cowboys 20, New York Giants 15 | 8:15 p.m. ET | Prime |
| 5 | Oct. 3 | Atlanta Falcons 36, Tampa Bay Buccaneers 30 | 8:15 p.m. ET | Prime |
| 6 | Oct. 10 | San Francisco 49ers @ Seattle Seahawks | 8:15 p.m. ET | Prime |
| 7 | Oct. 17 | Denver Broncos @ New Orleans Saints | 8:15 p.m. ET | Prime |
| 8 | Oct. 24 | Minnesota Vikings @ Los Angeles Rams | 8:15 p.m. ET | Prime |
| 9 | Oct. 31 | Houston Texans at New York Jets | 8:15 p.m. ET | Prime |
| 10 | Nov. 7 | Cincinnati Bengals @ Baltimore Ravens | 8:15 p.m. ET | Prime |
| 11 | Nov. 14 | Washington Commanders @ Philadelphia Eagles | 8:15 p.m. ET | Prime |
| 12 | Nov. 21 | Pittsburgh Steelers @ Cleveland Browns | 8:20 p.m. ET | Prime |
| 13 | Nov. 28 | Miami Dolphins @ Green Bay Packers | 8:15 p.m. ET | NBC |
| 14 | Dec. 5 | Green Bay Packers @ Detroit Lions | 8:15 p.m. ET | Prime |
| 15 | Dec. 12 | Los Angeles Rams @ San Francisco 49ers | 8:15 p.m. ET | Prime |
| 16 | Dec. 19 | Cleveland Browns @ Cincinnati Bengals | 8:15 p.m. ET | Prime |
| 17 | Dec. 26 | Seattle Seahawks @ Chicago Bears | 8:15 p.m. ET | Prime |
Thursday Night Football betting results for 2023-24
Below is the full betting recap for last season’s Thursday night games.
Week 1: Detroit Lions 21, Kansas City Chiefs 20
The Chiefs kicked off the season at home with plenty of fanfare as the defending Super Bowl champions, but the Lions delivered an upset with some help from a 50-yard interception return for a touchdown. Detroit got the cover after coming in as four-point underdogs. The final score fell 12 points short of matching the game’s over/under line of 53.
Week 2: Philadelphia Eagles 34, Minnesota Vikings 28
The defending NFC champion Eagles got off to a bit of a slow start at home in the first half, but Jalen Hurts and the offense eventually found their stride en route to the team’s second straight win to start the season. The Eagles came in favored by six points and won by that exact margin. The final score beat the line of 49 by a wide margin.
Week 3: San Francisco 49ers 30, New York Giants 12
The 49ers continued their unbeaten start by shutting down the Giants en route to a victory that saw Christian McCaffrey and Deebo Samuel both find the end zone. San Francisco came in as a 10.5-point favorite and easily covered the spread here. The final score fell just short of the total line of 43.5.
Week 4: Detroit Lions 34, Green Bay Packers 20
The Lions got their second TNF win of the season with help from David Montgomery, who ran for three touchdowns on the night. Detroit came in as a 2.5-point favorite and once again got the cover with plenty to spare. The final score was also well over the line of 45.
Week 5: Chicago Bears 40, Washington Commanders 20
The Bears had a breakout night on offense, as Justin Fields threw for four TDs and D.J. Moore caught three of them, totaling 230 yards receiving in the game. Chicago had been six-point underdogs, and with an over/under line of 45 points, the final tally went well over that mark.
Week 6: Kansas City Chiefs 19, Denver Broncos 8
In a game that saw much lower offensive output than expected, the Chiefs came away with a win thanks to a strong effort from a defensive unit that forced three turnovers. Kansas City barely covered the spread after coming into this game as a 10.5-point favorite. The final score was well under the line of 47.5.
Week 7: Jacksonville Jaguars 31, New Orleans Saints 24
The Jaguars had a big night on offense while on the road in New Orleans, and Travis Etienne found the end zone twice in the first half. Justin Lawrence played through a knee issue to finish with 204 yards and one TD through the air. The Jaguars covered after coming into the game as 2.5-point underdogs. With the total line at a low 41.5, the final result was over by a considerable margin.
Week 8: Buffalo Bills 24, Tampa Bay Buccaneers 18
The Bills rebounded with a win as Josh Allen threw for two touchdowns and ran for a third. Baker Mayfield had two TDs through the air but was also picked off once in the game. Buffalo failed to cover the spread after coming into the game as a 10-point favorite. The final score also fell short of the 43-point line by one point.
Week 9: Pittsburgh Steelers 20, Tennessee Titans 16
The Steelers once again picked up a win despite meager offensive output. Kenny Pickett got the start even after leaving the prior week’s game with a rib injury, making the quick turnaround to throw for one TD and 160 yards. The Steelers got the cover by the slimmest of margins after coming in as three-point favorites. For the sixth time in a row, the point total for a Steelers game ended with the under line cashing.
Week 10: Chicago Bears 16, Carolina Panthers 13
The Bears got their third win of the season at home against the struggling Panthers. Chicago held rookie QB Bryce Young to 185 yards passing in the win and won by exactly the three-point margin the team was favored by. The final tally was well under the line of 38 points.
Week 11: Baltimore Ravens 34, Cincinnati Bengals 20
The Ravens had another solid outing and a strong performance from QB Lamar Jackson, but the Bengals suffered a major blow when QB Joe Burrow suffered a season-ending wrist injury in the loss. Baltimore got the cover after coming in as four-point favorites. The total was over the line of 46.5 points.
Week 12: San Francisco 49ers 31, Seattle Seahawks 13
The 49ers got a third straight win, this time steamrolling their division rivals on the road. RB Christian McCaffrey had another big game, finishing with 114 yards rushing and two TDs on the ground. San Francisco came in as seven-point favorites and easily covered the spread. The final score was just over the line of 43 points.
Week 13: Dallas Cowboys 41, Seattle Seahawks 35
The Cowboys outscored the Seahawks 14-7 in the fourth quarter to remain undefeated at home, handing Seattle a second straight Thursday night loss. Dak Prescott threw three TD passes in the win. Dallas did not cover the spread after coming in as a nine-point favorite. The final tally was well over the total line of 47.5 points.
Week 14: New England Patriots 21, Pittsburgh Steelers 18
The Patriots picked up just their second road win of the season, with QB Bailey Zappe throwing for three TDs and one INT in his best performance since taking over at QB. The Patriots covered after coming in as five-point underdogs. The final score was easily over the total line of 30.5 points.
Week 15: Las Vegas Raiders 63, Los Angeles Chargers 21
The Raiders scorched the Chargers in a major blowout that was made only slightly more respectable by a 14-point fourth quarter from Los Angeles. QB Aidan O’Connell threw for four TDs in the win. The Raiders easily covered the spread, and the final tally exceeded the total by a whopping 48 points.
Week 16: Los Angeles Rams 30, New Orleans Saints 22
The Rams picked up a home win, and QB Matthew Stafford threw for 328 yards and two TDs. Los Angeles got the cover after coming in as a four-point favorite. The final score was over the total line of 45.5 points.
Week 17: Cleveland Browns 37, New York Jets 20
The Browns got another solid performance out of QB Joe Flacco, who threw for 309 yards with three TDs and one INT, as the team clinched a playoff spot with the win. Cleveland came in as seven-point favorites here and easily got the cover. The final tally was well over a total set at 33.5 points.
Other ways to bet on Thursday Night Football
As you dig deeper into how to bet on the NFL and the Thursday Night Football betting menu, you’ll find a host of other options. Here’s a look at some of the other ways to bet on the first game of the NFL week.
- Single-game parlays: You can place multi-leg wagers just for the TNF game. For example, you could wager on the over/under on total points and a favorite prop or two. The odds will depend on the selections you add to your slip, and you must get all your picks right to win.
- In-game betting: You can wager in real time as the TNF game plays out. Live betting opens as soon as the game kicks off and can keep going until the final whistle blows. You’ll see updated odds and wagers throughout the game, including options for spreads, totals, props, quarters, and halves.
- Alternate lines: If you’re not happy with the main pregame spreads and totals, sportsbooks offer alternate lines where you can give or take additional points. The odds will shift based on the number that you choose, as alternate lines give you the option of taking on more safety or risk for your bets.
Beyond betting on TNF on a standalone basis, you can also use the game as a starting point for multi-game parlays. For example, you could tie together the moneyline outcome with other bets from the full Sunday slate or Monday Night Football.
Thursday Night Football history/trends
Thursday Night Football became a regular part of the NFL schedule in 2006. Initially reserved for the latter part of the year, TNF has since expanded to become a staple of the weekly NFL slate.
The primetime game has shifted around broadcast outlets several times throughout its history. Amazon Prime is now the main home for TNF, but the Week 1 season opener and Thanksgiving night game will be on NBC.
Since 2006, all 32 teams have played multiple times on TNF. The San Francisco 49ers lead the way with 19 appearances through the end of the 2023-24 NFL season, while the Detroit Lions have appeared the fewest times with four.
Some squads have excelled under the bright TNF lights on an all-time basis. Here are the top five team records since 2006 and through last season.
- Kansas City Chiefs: 11-3, .786
- Indianapolis Colts: 12-4, .750
- New England Patriots: 10-4, .714
- Dallas Cowboys: 12-5, .706
- Baltimore Ravens: 12-5, .706
At the opposite end of the spectrum, a number of clubs have struggled so far on TNF:
- New York Jets: 6-12, .333
- Arizona Cardinals: 5-10, .333
- Minnesota Vikings: 3-6, .333
- New Orleans Saints: 4-9, .308
- Tampa Bay Buccaneers: 4-11, .267
For the 2023-24 season, 17 NFL games took place on Thursday night. Here’s how the trends and splits shook out for the season:
- Moneyline: Favorites 13-4
- Spreads: Favorites 10-5-2
- Totals: Over 11-6
- Home/away: Home 11-6
Thursday Night Football FAQ
Amazon Prime is the broadcast home for the majority of this season’s Thursday Night Football schedule. The subscription service will cover all games with the exception of the Week 1 opener and the Thanksgiving night game, both of which are on NBC. For those two games, viewers can also stream the action on the NBC Sports app or Peacock.
Due to the short week of preparation and not having to travel, there is a perceived built-in advantage for home teams during Thursday Night Football. However, home teams were just 6-11 over the course of 2022’s TNF slate. As always, view each game on its own merits when making wagering decisions.
There were occasional NFL Thursday night games from the late 1970s onward, but it has been a regular part of the schedule since 2006. The first game for the modern era took place on Nov. 23, 2006. The Kansas City Chiefs picked up a 19-10 victory over the visiting Denver Broncos on Thanksgiving night.
The Las Vegas Raiders defeated the Los Angeles Chargers by a score of 63-21 on Dec. 14, 2023. For bettors, the Raiders at -3 and over 36 points were the correct calls.