Thursday Night Football in Week 15 will see the Los Angeles Rams hit the road to face the San Francisco 49ers on December 12. Currently, the Niners are a -2.5 home favorite on the point spread. The Rams are at +124 on the moneyline as the road team.
Read on for the latest betting lines on Thursday’s Rams vs. 49ers game, plus a recap of how teams performed against the spread and on totals throughout last season’s Thursday Night Football schedule.
TNF betting odds: Rams at 49ers
Thursday Night Football player props
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Today’s Sportsbook Offers in Virginia
Thursday Night Football odds: L.A. Rams at San Francisco 49ers
- Spread: Rams Los Angeles Rams +3 on BetRivers, 49ers San Francisco 49ers -3 on BetRivers
- Moneyline: Rams Los Angeles Rams +135 on Bet365, 49ers San Francisco 49ers -152 on BetRivers
- Total: 17.5 (-105) on FanDuel
This matchup is a biggie as the result will have significant implications on the tight NFC West race. When these teams faced each other in L.A., the Rams won 27-24.
The Los Angeles Rams are winners of two straight and 7-6 overall following their week 13 win over the Buffalo Bills on Sunday. QB Matthew Stafford completed 77% of his passes for 320 yards and two touchdowns, while WR Puca Nacua had a standout performance with 162 receiving yards and a touchdown.
The San Francisco 49ers improved to 6-7 following last weekend’s win against tbe Chicago Bears. QB Brock Purdy finished the game with 325 passing yards and two TDs, while backup RB Isaac Guerendo had 78 rushing yards and two touchdowns.
Head To Head
Last Updated on 01.15.2025| STATS | 
Rams
LAR | 
49ers
SF |
|---|---|---|
| Offense Ranking OFF RNK | 15th | 4th |
| Defense Ranking DEF RNK | 26th | 7th |
| Offense Net Yards Per Game OFF NET YPG | 331.4 | 376.3 |
| Defense Net Yards Per Game DEF NET YPG | 352.8 | 317.4 |
| Passing Yards Per Game PASS YPG | 227.5 | 249.1 |
| Turnovers Committed Per Game TOC PG | 0.8 | 1.6 |
2025 Thursday Night Football schedule
The complete Thursday Night Football schedule for 2024 is below.
| Week | Date | Matchup | Time (ET) | TV |
| 1 | Sept. 5 | Kansas City Chiefs 27, Baltimore Ravens 20 | 8:20 p.m. ET | NBC |
| 2 | Sept. 12 | Buffalo Bills 31, Miami Dolphins 10 | 8:15 p.m. ET | Prime |
| 3 | Sept. 19 | New York Jets 24, New England Patriots 3 | 8:15 p.m. ET | Prime |
| 4 | Sept. 26 | Dallas Cowboys 20, New York Giants 15 | 8:15 p.m. ET | Prime |
| 5 | Oct. 3 | Atlanta Falcons 36, Tampa Bay Buccaneers 30 | 8:15 p.m. ET | Prime |
| 6 | Oct. 10 | San Francisco 49ers 36, Seattle Seahawks 24 | 8:15 p.m. ET | Prime |
| 7 | Oct. 17 | Denver Broncos 33, New Orleans Saints 10 | 8:15 p.m. ET | Prime |
| 8 | Oct. 24 | Los Angeles Rams 30, Minnesota Vikings 20 | 8:15 p.m. ET | Prime |
| 9 | Oct. 31 | New York Jets 21, Houston Texans 13 | 8:15 p.m. ET | Prime |
| 10 | Nov. 7 | Baltimore Ravens 35, Cincinnati Bengals 34 | 8:15 p.m. ET | Prime |
| 11 | Nov. 14 | Philadelphia Eagles 26, Washington Commanders 18 | 8:15 p.m. ET | Prime |
| 12 | Nov. 21 | Cleveland Browns 24, Pittsburgh Steelers 19 | 8:20 p.m. ET | Prime |
| 13 | Nov. 28 | Green Bay Packers 30, Miami Dolphins 17 | 8:15 p.m. ET | NBC |
| 14 | Dec. 5 | Detroit Lions 34, Green Bay Packers 31 | 8:15 p.m. ET | Prime |
| 15 | Dec. 12 | Los Angeles Rams @ San Francisco 49ers | 8:15 p.m. ET | Prime |
| 16 | Dec. 19 | Cleveland Browns @ Cincinnati Bengals | 8:15 p.m. ET | Prime |
| 17 | Dec. 26 | Seattle Seahawks @ Chicago Bears | 8:15 p.m. ET | Prime |
Other ways to bet on Thursday Night Football
As you dig deeper into how to bet on the NFL and the Thursday Night Football betting menu, you’ll find a host of other options. Here’s a look at some of the other ways to bet on the first game of the NFL week.
- Single-game parlays: You can place multi-leg wagers just for the TNF game. For example, you could wager on the over/under on total points and a favorite prop or two. The odds will depend on the selections you add to your slip, and you must get all your picks right to win.
- In-game betting: You can wager in real time as the TNF game plays out. Live betting opens as soon as the game kicks off and can keep going until the final whistle blows. You’ll see updated odds and wagers throughout the game, including options for spreads, totals, props, quarters, and halves.
- Alternate lines: If you’re not happy with the main pregame spreads and totals, sportsbooks offer alternate lines where you can give or take additional points. The odds will shift based on the number that you choose, as alternate lines give you the option of taking on more safety or risk for your bets.
Beyond betting on TNF on a standalone basis, you can also use the game as a starting point for multi-game parlays. For example, you could tie together the moneyline outcome with other bets from the full Sunday slate or Monday Night Football.
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Thursday Night Football history/trends
Thursday Night Football became a regular part of the NFL schedule in 2006. Initially reserved for the latter part of the year, TNF has since expanded to become a staple of the weekly NFL slate.
The primetime game has shifted around broadcast outlets several times throughout its history. Amazon Prime is now the main home for TNF, but the Week 1 season opener and Thanksgiving night game will be on NBC.
Since 2006, all 32 teams have played multiple times on TNF. The San Francisco 49ers lead the way with 19 appearances through the end of the 2023-24 NFL season, while the Detroit Lions have appeared the fewest times with four.
Some squads have excelled under the bright TNF lights on an all-time basis. Here are the top five team records since 2006 and through last season.
- Kansas City Chiefs: 11-3, .786
- Indianapolis Colts: 12-4, .750
- New England Patriots: 10-4, .714
- Dallas Cowboys: 12-5, .706
- Baltimore Ravens: 12-5, .706
At the opposite end of the spectrum, a number of clubs have struggled so far on TNF:
- New York Jets: 6-12, .333
- Arizona Cardinals: 5-10, .333
- Minnesota Vikings: 3-6, .333
- New Orleans Saints: 4-9, .308
- Tampa Bay Buccaneers: 4-11, .267
For the 2023-24 season, 17 NFL games took place on Thursday night. Here’s how the trends and splits shook out for the season:
- Moneyline: Favorites 13-4
- Spreads: Favorites 10-5-2
- Totals: Over 11-6
- Home/away: Home 11-6
Thursday Night Football FAQ
Amazon Prime is the broadcast home for the majority of this season’s Thursday Night Football schedule. The subscription service will cover all games with the exception of the Week 1 opener and the Thanksgiving night game, both of which are on NBC. For those two games, viewers can also stream the action on the NBC Sports app or Peacock.
Due to the short week of preparation and not having to travel, there is a perceived built-in advantage for home teams during Thursday Night Football. However, home teams were just 6-11 over the course of 2022’s TNF slate. As always, view each game on its own merits when making wagering decisions.
There were occasional NFL Thursday night games from the late 1970s onward, but it has been a regular part of the schedule since 2006. The first game for the modern era took place on Nov. 23, 2006. The Kansas City Chiefs picked up a 19-10 victory over the visiting Denver Broncos on Thanksgiving night.
The Las Vegas Raiders defeated the Los Angeles Chargers by a score of 63-21 on Dec. 14, 2023. For bettors, the Raiders at -3 and over 36 points were the correct calls.