Week 15 NFL Odds: Opening Spreads, Moneylines, Totals

The bye weeks are complete, meaning we have a robust NFL Week 15 schedule that features multiple games with postseason implications. 

LSR offers the latest NFL betting odds from top sports betting sites, along with a quick-hitting betting preview for Week 15 games.

NFL Week 15 odds: Spreads, moneylines, totals

NFL Week 15 opening spreads, lines, totals

Week 15 games odds and analysis 

Los Angeles Rams (+2.5) at San Francisco 49ers (-2.5)

The Rams notched a narrow 44-42 win over the Bills in what could well be the game of the season when all is said and done. Los Angeles went back to basics and ran virtually everything through the elite trio of Puka Nacua, Cooper Kupp and Kyren Williams with great success. The matchup remains tough in this spot against a Niners defense that looked rejuvenated at the expense of the Bears.

The 49ers recorded a 38-13 walloping in that game against Chicago, sacking Caleb Williams seven times in the process. Brock Purdy was also near perfect with just five incompletions (and 325 yards) on 25 attempts but the Niners saw impressive rookie Isaac Guerendo go down with a foot sprain that significantly lowers his chances of being ready to play on a short week and bumps journeyman Patrick Taylor into the No. 1 role for the moment. 

The Rams hold an 0-2 mark ATS as a road underdog but are 2-1 against the number in division games. The 49ers are 4-3 ATS as a home favorite but just 1-3 against NFC West teams, with a 27-24 loss to L.A. at SoFi Stadium back in Week 3 part of that record.

The game has opened with a projected total of 48.5 points.

Cincinnati Bengals (-5) at Tennessee Titans (+5)

The Bengals are 4-8 heading into Monday night’s interconference battle against the Cowboys. Cincinnati has all of Joe Burrow, Chase Brown, Ja’Marr Chase and Tee Higgins healthy and seems like a clear favorite on paper, but Zac Taylor’s squad has found some interesting ways to lose during its three-game skid. 

The Titans are now 3-10 and officially out of postseason contention following an embarrassing 10-6 loss to the Jaguars at home in Week 14. Tennessee’s Will Levis can’t seem to piece together game-to-game consistency and Tony Pollard continues to be the one reliable weekly piece on the offense. If Burrow and company come in clicking on all cylinders in this spot, Levis could have a difficult time keeping up.

Despite their disappointing season, the Bengals have played competitively in most losses and are 6-1 ATS as a road team following Monday night’s win over the Cowboys. The Titans, meanwhile, have been futile against the number at home, going an NFL-worst 0-6.

The game has opened with a projected total of 47.5 points.

Baltimore Ravens (-14.5) at New York Giants (+14.5)

The Ravens fell to the Eagles at home in a marquee Week 13 matchup before going on bye in Week 14. Following the Steelers’ win over the Browns in Week 14, Baltimore is now two games back in the AFC North at 8-5. This game does present a golden opportunity for Baltimore to flex its muscle, but the caliber of opponent prevents it from being anything resembling a litmus test. 

The Giants lost for the seventh time in as many home games in Week 14, dropping a 14-11 decision to the Saints. Drew Lock didn’t really look any better with a full week of practice and Malik Nabers played through a hip flexor injury. New York is 2-11 and rightfully a double-digit home underdog, although a return to Tommy DeVito at quarterback could provide at least a small spark.

The already massive spread continues to climb, up to 16 by Wednesday night thanks in part to the announcement Drew Lock will not play for the Giants due to a heel injury. 

Baltimore is 4-3 ATS as a road team, although this is by far the most they’ve been favored by. Meanwhile, the Giants are 2-5 against the number at home, although they’re 0-7 straight up at home.

Baltimore is just 27-26-1 ATS with a rest advantage during John Harbaugh’s tenure as head coach, but 37-31-4 against the number against NFC opponents.

The game has opened with a projected total of 43.5 points.

New York Jets (-3.5) at Jacksonville Jaguars (+3.5)

Despite the absences of Sauce Gardner (hamstring) and Breece Hall (knee), the Jets nearly upended the Dolphins in South Florida before dropping a 32-26 decision in overtime. There were was optimism to be gleaned from Aaron Rodgers’ first 300-yard performance since his Packers days, as well as Davante Adams and Garrett Wilson combining for a 16-223-1 line. The matchup against this Jaguars secondary is exponentially better, offering some hope for a successful encore.

The Jaguars snapped a five-game losing streak with a 10-6 victory over the Titans on the road. Mac Jones looked the best he has among his three starts this season, although he tossed two interceptions after throwing two TDs in an impressive performance in emergency duty in Week 13. The matchup against the Jets secondary should be tougher irrespective of whether Gardner can play.

The Jets are only 2-4 ATS as a road team this season, while the Jaguars are 2-2-1 against the spread at home.

The game has opened with a projected total of 40.5 points.

Washington Commanders (-7.5) at New Orleans Saints (+7.5)

The Commanders come back from a Week 14 bye with an 8-5 victory and right in the thick of the NFC wild-card picture. Jayden Daniels and co. was able to notch a key convincing victory to snap a losing streak before heading into the off week, thumping the Titans by a 42-19 score in Week 13. 

The Saints were able to get their third win in four tries under interim coach Darren Rizzi when they toppled the Giants by a 14-11 score on the road in Week 14. However, of overriding concern with the fracture Derek Carr suffered on his non-throwing hand late in the game while vaulting over his own player. Carr apparently won’t need surgery according to latest reports and could even potentially be available for this game.

The Commanders are 3-2-1 ATS on the road this season and 1-1 against the number with a rest advantage, while the Saints are 3-4 ATS at home and 1-2 when playing with a rest disadvantage.

The game has opened with a projected total of 43 points.

Miami Dolphins (+2) at Houston Texans (-2)

The Dolphins got more than they likely bargained for from the Jets at home on Sunday, but Miami overcame a turn-back-the-clock performance by Aaron Rodgers to squeak by a Jets team missing Breece Hall (knee) and Sauce Gardner (hamstring) in overtime. Tua Tagovailoa and Co. are now 6-7 and remain in the thick of the AFC wild-card conversation.

The Houston Texans had a much-needed respite in Week 14 with their bye, and they managed to go into it with some momentum in the form of a 23-20 victory over the Jaguars in Week 13. With its 8-5 record, Houston maintains a two-game lead in the AFC South over the Colts.

The Dolphins are 3-3 ATS on the road and 2-3 ATS following a win. The Texans are 2-3-1 against the number at home as well as 1-1 ATS when playing with a rest advantage.

The over/under line for this one opened at 47 points.

Kansas City Chiefs (-5.5) at Cleveland Browns (+5.5)

It may not be what Patrick Mahomes wants, but the Chiefs keep squeaking by opponents with regularity and are now 12-1 after a 19-17 win over the short-handed Chargers on Sunday night. KC’s offense does look a bit disjointed at times, but this matchup against an erratic Browns unit is one that may facilitate one of the Chiefs’ better outings, especially with Isiah Pacheco looking good again Sunday while bumping up his workload.

The Browns couldn’t pull off the season sweep of the Steelers in Week 14. Cleveland fell to Pittsburgh by a 27-14 score and saw Jameis Winston throw a pair of picks while taking three sacks. The defensive matchup isn’t quite as daunting here and Cleveland will be at home, possibly with Cedric Tillman rejoining the lineup after a two-game absence due to a concussion. 

The Chiefs are 3-3 ATS on the road, while the Browns are 2-4 against the number at home.

The game has opened with a projected total of 45 points.

Dallas Cowboys (+1.5) at Carolina Panthers (-1.5)

The Cowboys will look to extend their improbable winning streak to three games when they face the Bengals on Monday night to close out Week 14. Cooper Rush has played better in recent starts and has enough talent to take advantage of a matchup such as the one the Panthers present, although a surging Rico Dowdle might be in the best position to thrive.

The Panthers gave another elite team quite the scare in Week 14. Carolina pushed the Eagles to the limit on the road before turning the ball over on downs late in a 22-16 loss. Nevertheless, Bryce Young continued to demonstrate improvement and Adam Thielen once again looked the part of a legitimate No. 1 receiver. However, the ACL tear suffered by rookie Jonathon Brooks on the same knee he injured in college last season was a particularly disheartening aspect of the defeat.

The Cowboys are 3-3 ATS on the road and 1-1 when playing with a rest disadvantage. The Panthers are 3-3 against the number at home and are also 1-1 when playing with a rest edge.

The game has opened with a projected total of 43 points.

Pittsburgh Steelers (+4.5) at Philadelphia Eagles (-4.5)

The Steelers kept rolling in Week 14, exacting some revenge on a Browns team that had upset them in a Cleveland snowstorm in Week 12. Russell Wilson impressively managed without top target George Pickens (hamstring) in the 27-14 win, connecting with Van Jefferson and Pat Freiermuth for TDs as Pittsburgh moved to 10-3.

The Eagles either played down to the level of their opponent or the Panthers are simply an appreciably better team than they were to start the season. Either way, Carolina was in the game until the final drive of a 22-16 loss to Philadelphia on Sunday. Saquon Barkley did eclipse 100 yards again and now holds the franchise record for most such performances in one season, but the spread for this intrastate, interconference showdown could arguably get smaller if Pickens is announced as available.

The Steelers are a perfect 3-0 ATS as road underdogs this season, while the Eagles notably check in with just a 1-4 tally against the number as home favorites.

This game had a total line of 44.5 points at opening.

New England Patriots (+6.5) at Arizona Cardinals (-6.5)

The Patriots lost two of their last three games before the Week 14 bye by single digits, a sign of how much more competitive the team generally has been with Drake Maye guiding the offense. A week off to further digest the playbook could be particularly helpful to the talented rookie, as could the dome environment and inconsistent Cardinals defense.

Arizona fell for the third straight game and second time to the Seahawks during that span on Sunday. Kyler Murray and co. continue to look merely average on offense despite some big names at the skill positions, although this matchup against New England’s questionable run defense could be the key to getting James Conner unleashed early and setting up the pass well.

The Patriots have held up fairly well against the number as a road underdog, going 3-3 ATS in that split. The Cardinals are 1-2 ATS as a home favorite but a perfect 4-0 in interconference games.

The game has opened with a projected total of 46 points.

Tampa Bay Buccaneers (+3) at Los Angeles Chargers (-3)

The Tampa Bay Buccaneers had a couple of stumbles due to turnovers but ultimately posted a 28-13 win over an overmatched Raiders team at Raymond James Stadium on Sunday. Tampa Bay nearly got another 300-yard effort from Baker Mayfield, but one concern coming out of the victory was the back injury that forced Bucky Irving out in the first half. 

The Chargers suffered a narrow loss to the Chiefs on Sunday Night Football at Arrowhead and did so without Ladd McConkey, who’s out due to shoulder and knee injuries. McConkey should have enough time to be healthy for this matchup, but Los Angeles’ J.K. Dobbins-less running game will have even more of an uphill battle than usual against Tampa Bay’s typically stingy run defense.

The Buccaneers are 2-1 ATS as a road underdog, while the Chargers are a perfect 4-0 against the spread as home favorites and 3-1 in interconference games.

The over/under line opened at 46.5 points.

Buffalo Bills (+2.5) at Detroit Lions (-2.5)

The Bills were part of what ultimately may prove to be the game of the season in Week 14, as they dropped a 44-42 decision to the Los Angeles Rams. Buffalo fell behind by multiple scores in the second half before nearly mounting a successful comeback behind Josh Allen’s six total touchdowns (three passing, three rushing). Buffalo’s receiving corps could be at full strength if Keon Coleman finally makes it back from his wrist injury. 

The Detroit Lions climbed to 11-1 with a hard-fought 34-31 win over the Packers on Thursday Night Football to start Week 14. Detroit will enjoy a particularly large rest advantage for this interconference showdown considering Buffalo’s cross-country return home Sunday and the grueling nature of the Bills’ loss. Jared Goff enters this game running hot with a 9:1 TD:INT ratio in his last four games.

The Bills are 1-2 ATS as a road underdog this season, while the Lions are 4-3 ATS as a home favorite. The two teams are 2-2 and 3-1, respectively, ATS in interconference games.

The over/under line for this one opened at 53.5 points, by far the highest of the week.

Indianapolis Colts (+4) at Denver Broncos (-4)

The Colts will look to remain in the AFC wild-card conversation coming out of the Week 14 bye after getting by the Patriots, 25-24, in Week 13. Anthony Richardson’s erratic passing and turnover-prone ways are particularly dangerous when considering the matchup against the aggressive Broncos defense. 

The Broncos were also off in Week 14 after getting past the Browns in a wild Monday night battle to close out Week 13. Denver is on a three-game winning streak and now sports an 8-5 record, particularly impressive with a rookie at the controls of the offense. Bo Nix could continue augmenting his stellar rookie body of work in this matchup as well, considering the Colts’ inconsistencies on defense.

The Colts are actually an impressive 4-1 ATS as a road underdog, while the Broncos are an NFL-best 4-0 against the number as a home favorite.

The game has opened with a projected total of 43.5 points.

Green Bay Packers (-2.5) at Seattle Seahawks (+2.5)

The Packers essentially lost any hope of catching the Lions for the NFC North crown with their 34-31 loss on Thursday night. However, Green Bay remains an elite wild-card contender and has one of the league’s hottest backs in Josh Jacobs. The offseason addition has a whopping eight rushing TDs in the last four games, including a pair of three-score tallies. 

The Seattle Seahawks won their fourth straight and scored their second victory over the Cardinals in three weeks on Sunday. Seattle dispatched Arizona by a 30-18 score on the road despite being without Kenneth Walker III, who sat out with ankle and calf injuries. Zach Charbonnet’s 193 total yards and two touchdowns more than made up for his absence, and the performance gives the Seahawks some peace of mind if Walker is still sidelined for this marquee conference battle.

The Packers are only 1-2 ATS as a road favorite this season and 9-13 since Matt LaFleur’s arrival in 2019, while the Seahawks are 1-3 against the number as home underdogs.

The total for this one opened at 47 points.

Chicago Bears (+6.5) at Minnesota Vikings (-6.5)

The Bears’ record fell to 4-9 with a seventh straight loss in Week 14, an ugly 38-13 thumping at the hands of the 49ers. Chicago allowed Caleb Williams to take another seven sacks and looked atypically poor defending the pass. The matchup is potentially harder on both sides of the ball in this spot, as the Vikings’ Sam Darnold looked near unstoppable in Week 14 and Minnesota’s defense is perhaps even more aggressive at getting after the quarterback.

Darnold’s career-best 347-yard, five-touchdown performance against the Falcons in a 42-21 Week 14 win was the latest installment in his career resurgence. The prolific effort facilitated 100-yard performances for Jordan Addison and Justin Jefferson, and Darnold already compiled 330 yards and a pair of touchdowns in the first meeting between the teams.

The Bears’ ATS record as a road underdog is a microcosm of their season-long misery, as they’re just 1-4-1 against the number in that split. The Vikings are 2-2 ATS as a home favorite. However, Chicago is 2-0-1 ATS in division games.

The game has opened with a projected total of 43.5 points.

Atlanta Falcons (-4.5) at Las Vegas Raiders (+4.5)

The Falcons’ 42-21 loss the Vikings in Week 14 extended a worrisome pattern for both the team as a whole and Kirk Cousins in particular. Atlanta lost its fourth straight game and its share of first place in the NFC South in the process. Head coach Raheem Morris confirmed he’s sticking with Cousins at his quarterback and leaving rookie Michael Penix on the sideline for now, but any worsening of 0:8 TD:INT that Cousins has mustered in the last four games could change that.

The Raiders saw their own difficult season get worse Sunday when Aidan O’Connell suffered a bone bruise in his knee that currently has him listed as week-to-week. Las Vegas is just playing out the season at this point with nine straight losses and a 2-11 record, and Antonio Pierce may be forced to call on one-time Falcons draft pick Desmond Ridder to start this game.

The Falcons are 2-1 as road favorites this season but 0-4 against the number against AFC foes. The Raiders are 2-2 and 1-2 ATS as home underdogs and in non-conference games, respectively.

The game has opened with a projected total of 44 points.