Week 13 NFL Odds: Opening Spreads, Moneylines, Totals

The NFL’s Thanksgiving weekend schedule is replete with intriguing matchups and arguably marks the start of what one could consider the season’s stretch run.

Here are the latest NFL betting odds from top sportsbooks, along with a quick-hitting preview for key Week 13 games.

NFL Week 13 odds: Spreads, moneylines, totals

NFL Week 13 opening spreads, lines, totals

NFL Week 13 games odds and analysis 

Chicago Bears (+10.5) at Detroit Lions (-10.5)

The Bears continued to monopolize heartbreaking finishes Sunday, mounting a valiant fourth-quarter comeback only to lose to the Vikings in OT, 30-27. Chicago is now 4-7, and although the offense and Caleb Williams in particular have looked much more cohesive in the first two games under new coordinator Thomas Brown, they’re still coming out on the losing end by narrow margins.

The Lions had nowhere near the walk in the park they’d enjoyed against the Jaguars at home in Week 11 when they faced the Colts on Sunday. Nevertheless, the end result was another double-digit victory, this time by a 24-6 margin. David Montgomery did suffer a shoulder injury that knocked him out of the game, but he’s vowed to be available for this Thanksgiving clash against his old squad.

The Bears are notably an NFL-worst 0-3-1 ATS as road underdogs. Meanwhile, the Lions are 4-1 against the number as a home favorite and 2-0 in division games.

The game has opened with a projected total of 48.5 points.

New York Giants (+4) at Dallas Cowboys (-4)

The 2024 version of the Tommy DeVito Experience got off to a very ragged start Sunday. New York fell to Tampa Bay by a 30-7 score at home and coming off a bye week. The G-Men’s lost season limps into this divisional matchup on a short week, and rookie wideout Malik Nabers is grousing about not having gotten any targets until the second half of the lopsided loss.

The Cowboys have had a pretty miserable season in their own right. However, it got a momentary reprieve in a wild road win over the arch-rival Commanders on Sunday, one that featured a combined 41 fourth-quarter points, with 31 of those coming in the final 3:02. Cooper Rush has looked more competent in his last two games and now draws a matchup against a Giants team that’s started to question its own effort.

The Giants are only 1-3 ATS in division games. The Cowboys are just 1-2 in that same split, however, and a woeful 0-5 against the number at home with a glaring -21.1 ATS +/-.

The game has opened with a projected total of 38 points.

Miami Dolphins (+3.5) at Green Bay Packers (-3.5)

The Dolphins continued to show signs of life Sunday with a second consecutive win that saw Tua Tagovailoa click early and often with Jaylen Waddle and Jonnu Smith. Tyreek Hill continues to produce well below his standards, but if all three pass catchers, along with De’Von Achane, who notched two receiving TDs himself Sunday, all click simultaneously, we could see a true blowup performance by Miami. 

The Packers managed a comfortable 38-10 win over the visiting 49ers to prep for this Thanksgiving night showdown. In fairness, it was a San Francisco team that was short-handed at the most important position, as Brock Purdy sat out due to a shoulder injury. Nevertheless, Josh Jacobs continued a stellar season with three rushing TDs, and Green Bay is now 8-3 and positioning itself well for the postseason.

The Dolphins are 2-2 against the spread as a road underdog this season but have famously struggled in cold-weather climates in recent seasons. The Packers, however, are just 2-3 ATS at home.

This game opened with an over/under line of 47.5 points.

Las Vegas Raiders (+13) at Kansas City Chiefs (-13)

The Raiders’ chances of duplicating their Christmas Day shocker against the Chiefs from last season in this Black Friday matchup look extremely slim. The momentum the team enjoyed last season during Antonio Pierce’s interim coaching stint is a long-forgotten memory. Additionally, Gardner Minshew went down for the season with a broken collarbone suffered Sunday in a 29-19 loss to the Broncos. That leaves either Desmond Ridder or a potentially returning Aidan O’Connell as the starting QB for this divisional clash. O’Connell was the quarterback in last year’s holiday victory over KC but hasn’t played since Week 7 due to a broken thumb.

The Chiefs nearly suffered an upset Sunday that would have been even bigger than the aforementioned 2023 loss to the Raiders. The defending champs got all they could handle from the host Panthers before escaping with a 30-27 win. Patrick Mahomes is now on record saying he wants to see the team enjoy “calmer” fourth quarters via blowouts, and he could well get his wish in a game that should also feature the return of Isiah Pacheco from his leg injury.

The Raiders have furnished a 2-4 mark against the spread as road underdogs. Yet the Chiefs, with their penchant for razor-thin wins, are an uninspiring 2-3 versus the number as home favorites.

The game has opened with a projected total of 42.5 points.

Seattle Seahawks (-2.5) at New York Jets (+2.5)

The Seahawks’ defense had to have made head coach Mike Macdonald proud in its critical division win over the Cardinals in Week 12. Seattle relentlessly pressured Kyler Murray throughout the afternoon while limiting Arizona to six points. With a rematch with the Cardinals on tap in Week 14, Macdonald will have to guard against a letdown on this cross-country trip.

The Jets may be easy to take lightly despite their star-laden offense. New York can’t seem to get it together despite the All-Star cast, and there’s talk Aaron Rodgers is dealing with multiple injuries that he’s declined to have tested. Gang Green has lost seven of the last eight but does have all its key skill-position players healthy for this winnable game.

The Seahawks are a solid 2-1-1 against the number as a road team and have prevailed outright in two East Coast games versus the Patriots and Falcons.

The Jets are 2-3 ATS at home but curiously 0-2 with an AFC-worst ATS +/- of -18.5 points when playing with a rest advantage.

The game has opened with a projected total of 41.5 points.

Pittsburgh Steelers (+2.5) at Cincinnati Bengals (-2.5)

The Steelers suffered a rare loss when Jameis Winston and the Browns managed to upend them in blizzard-like conditions in Cleveland on Thursday night. Despite the loss, Russell Wilson continued to demonstrate improvement and a comfort level in Arthur Smith’s scheme while throwing for 270 yards and a touchdown. Justin Fields also continues to see a few designed run plays per game with solid results. 

The Bengals were off in Week 12 following a tough 34-27 loss to the Chargers on Sunday night in Week 11. Tee Higgins did return to action from a quadriceps injury in that game and didn’t miss a beat, posting a 9-148-1 line, and Ja’Marr Chase also contributed two touchdown receptions. The duo should pose quite a threat to even the talented Pittsburgh defense, especially coming off a bye week.

The Steelers are an impressive 4-2 ATS on the road this season and are notably an AFC-best 60-43-6 against the spread in division games during Mike Tomlin’s 17-plus seasons with the team. 

Cincy is 2-1 ATS in games against AFC North opponents and 4-2 ATS following a loss.

The total line for this one opened at 47.5 points.

Indianapolis Colts (-3) at New England Patriots (+3)

The Anthony Richardson carriage turned into a proverbial pumpkin in Week 12. Richardson looked much improved with his accuracy and efficiency in his Week 11 return to the starting job. However, there was major regression during Sunday’s 24-6 loss to the Lions in the form of an 11-for-28 passing line. Yet, this matchup against a Pats defense that was carved up by Tua Tagovailoa in Week 12 could help facilitate a resurgence.

New England was throttled by a 34-15 score in that road loss to the Dolphins. Drake Maye put together serviceable numbers but still looked like a rookie against a Miami defense that harassed him throughout the afternoon. Yet, Maye also could be set to put that poor effort behind him quickly considering Indy’s own defensive inconsistencies.

The Colts are an impressive 4-2 against the number on the road and 3-3 ATS after a loss. The Pats are just 1-3-1 versus the spread as a home underdog and 2-6 against the number following a defeat.

The game has opened with a projected total of 42.5 points.

Arizona Cardinals (+4) at Minnesota Vikings (-4)

The Cardinals put together a woeful performance in a key road divisional clash against the Seahawks on Sunday. Kyler Murray was mercilessly pressured by Seattle in the 16-6 loss, although Trey McBride offered a reminder of why he’s one of the league’s top tight ends with 12 receptions for 133 yards. However, the matchup gets even tougher for Murray and his side of the ball against a similarly aggressive Vikings defense.

Minnesota managed to pull off a third straight win the hard way, getting past the Bears on the road by a 30-27 score in overtime in Week 12. The Vikings did blow a two-touchdown fourth-quarter lead and often struggle to limit production through the air, so if Murray can get enough time, he could still find his way to some big plays in a game where he figures to have to remain aggressive.

The Cardinals are now 3-2 against the spread on the road after Sunday’s loss, but they’re 3-1 as a road dog. The Vikings are 3-1 ATS at home but just 1-1 as home favorites.

This game opened with an over/under line of 47 points.

Tennessee Titans (+5.5) at Washington Commanders (-5.5)

The Titans, which have been competitive in many losses, finally came out on top in one of those close contests. Tennessee upset the Texans on the road by a 32-27 score. Will Levis, Tony Pollard and Calvin Ridley were quite the trio to contend with during the victory and now draw a matchup against a Commanders defense that looked vulnerable often during a 34-26 loss to the Cowboys in which Cooper Rush and Rico Dowdle both enjoyed their fair share of success in.

Washington missed the opportunity to force overtime after a miracle 86-yard touchdown from Terry McLaurin when Austin Seibert hooked the PAT. The Commanders are now 7-5 and face the prospect of having to take on a tough Tennessee defense without their top two backs. Brian Robinson exited against Dallas twice due to an ankle injury, while Austin Ekeler suffered a scary concussion on an onside kick late in the game and could be hard-pressed to clear protocols in time for this matchup. 

The Titans are still just 2-4 ATS as a road underdog after Sunday’s win over Houston. Meanwhile, Washington fell to 4-2 against the number as a home favorite with the loss to Dallas and 2-1-1 in non-conference games.

The game has opened with a projected total of 44.5 points.

Los Angeles Chargers (-1.5) at Atlanta Falcons (+1.5)

The Chargers tangle with a second straight AFC North team when they host the Ravens to close out Week 12 on Monday night. The Bolts toppled the Bengals on Sunday night in Week 11 by a 34-27 score and are 7-3 in the wake of a four-game winning streak.

The Falcons were off in Week 12 after back-to-back losses to the Saints and Broncos, which left them at 6-5. That’s still good enough to lead a lackluster NFC South, even with a -30 point differential. Atlanta does have plenty of talent on offense but will hope Darnell Mooney’s hamstring injury healed up over the week off.

The Chargers are 2-1 ATS in non-conference games with an ATS +/- of +8.8 points. The Falcons are just 0-3 in that same split with a -14.8-point ATS +/- and 2-4 ATS as a home team.

The game has opened with a projected total of 48 points.

Houston Texans (-5) at Jacksonville Jaguars (+5)

The Texans’ surprising skid continued Sunday with a 32-27 home loss to the Titans. C.J. Stroud and Nico Collins did have their usual magic working. Yet, Joe Mixon was uncharacteristically bottled up by Tennessee’s underrated defense. Houston still has a solid two-game lead in the AFC South at 7-5 and could be more focused in this game more than they otherwise would have been had they not lost for the third time in four games.

The Jaguars had a mercifully timed bye week in Week 12 after a 52-6 thrashing at the hands of the Lions in Week 11. Trevor Lawrence’s shoulder injury will be the main storyline to watch in Jacksonville this week after head coach Doug Pederson was surprisingly spared from a firing during the bye.

The Texans are 3-3 ATS on the road and 2-2 after a loss. The Jags are 2-2 in their own right at home.

The game has opened with a projected total of 43.5 points.

Tampa Bay Buccaneers (-6) at Carolina Panthers (+6)

The Buccaneers got a much-needed win in Mike Evans’ return to action Sunday. Tampa Bay thumped the Giants on the road by a 30-7 score. Given the caliber of competition, that win may not prove much, but it did wonders for the Bucs’ hopes for staying in the hunt for the NFC South crown by pulling them within a game of Atlanta.

The Panthers, and Bryce Young in particular, continued to show plenty of improvement in a near-miracle upset of the Chiefs. Although Carolina fell by a 30-27 score, Young may have played his best game as a pro yet while Adam Thielen was able to return from his extended absence due to a hamstring injury and promising rookie Jonathon Brooks made his long-awaited NFL debut with a pair of carries.

The Bucs are now 4-1 ATS on the road and have a solid +9.7 ATS +/- in that split. The Panthers moved to 2-3 ATS as a home team. Both squads are 1-2 against the number in division games.

The game has opened with a projected total of 46.5 points.

Los Angeles Rams (-3) at New Orleans Saints (+3)

The Rams may have blown a golden opportunity on their home field Sunday night. Los Angeles was blown out, 37-20, by a visiting Eagles team playing without DeVonta Smith (hamstring). The Rams are fighting to remain in the NFC playoff conversation at 5-6 but interestingly remain road favorites for this tricky matchup as the week begins.

The Saints have already caught a couple of teams by surprise this season. New Orleans most recently ran over the Browns by a 35-14 score in Week 11 and have now had a bye week to get healthier. Taysom Hill had the game of his career with three touchdowns versus Cleveland and could have a big role again in this game with Chris Olave (concussion) still on injured reserve.

The Rams have furnished a 2-3 ATS mark as a road team and the same record after a loss. The Saints are 3-3 versus the number as a home team but 0-2 ATS when playing with a rest advantage

The game has opened with a projected total of 48.5 points.

Philadelphia Eagles (+3) at Baltimore Ravens (-3)

The Eagles passed a big test Sunday night with a 37-20 thumping of the Rams on the road. Philadelphia got it done without DeVonta Smith, who missed the game with a hamstring injury, as Saquon Barkley delivered an astounding 255-yard, two-touchdown night on the ground.

The Ravens will close out the Week 12 slate on Monday night with a road trip to Los Angeles to face the Chargers. Lamar Jackson and Co. will be aiming to erase the memory of a Week 11 slip-up against the Steelers and trying to take advantage of the fact that Pittsburgh lost to the Browns in Week 12.

The Eagles are 2-0 as road underdogs this season with an impressive ATS +/- of +14.3 points. Meanwhile, the Ravens are only 2-2-1 against the spread as a home favorite but do have an ATS +/- of +5.5 points in that split.

The over/under line for this game opened at 50.5 points.

San Francisco 49ers (+7) at Buffalo Bills (-7)

The 49ers fell to a worrisome 5-6 with a 38-10 drubbing at the hands of the Packers at Lambeau Field on Sunday. San Francisco looked nothing like itself on offense, with Brandon Allen leading the way in place of Brock Purdy, who missed the game with a shoulder injury. Purdy’s health will naturally be critical to monitor throughout the coming week.

The Bills were off in Week 12 after recording their sixth consecutive win with a 30-21 victory over the Chiefs in Week 11. Buffalo may well be the hottest team in the league and will likely see its home favorite status expand even further if Purdy is ultimately unavailable.

Following Sunday’s loss, the Niners are 0-1 ATS as road underdogs but 3-2 ATS following a defeat. The Bills are 3-2 in their own right as home favorites with an impressive ATS +/- of +10.0 points in that split. 

The over/under line for this one opened at 46.5 points.

Cleveland Browns (+5.5) at Denver Broncos (-5.5)

The Browns bounced back from their 21-point loss to the Saints in Week 11 to notch a big upset victory over the Steelers in Week 12. Cleveland will have plenty of rest ahead of this game given they recorded that victory on Thursday night to open the slate. Jameis Winston continues to play well but could be down a key receiver in Cedric Tillman for this game if he can’t clear concussion protocols in time for this contest.

The Broncos’ impressive run continued Sunday with a 29-19 win over the Raiders. Denver’s defense has proven elite on many weeks this season and Bo Nix already looks like a seasoned pro after head coach Sean Payton took the plunge and started him from Day 1. Minshew threw for 273 yards and two touchdowns Sunday to extend his streak without a turnover to three games. He’s getting it done without a dependable running game as well, making it all the more impressive.

The Browns are 2-3 ATS on the road and 0-2 vs. the number after a win with an ugly ATS +/- of -13.8 points. The Broncos are 3-2 ATS at home, 4-2 vs. the spread after a win and 1-1 when playing with a rest disadvantage.

The game has opened with a projected total of 42 points.