NFL Week 11 Odds: Spreads, Moneylines, Totals and Analysis

NFL Week 11 odds feature a number of high-profile matchups and division rivalries with playoff implications.

After NFL favorites began the season so hot that one sportsbook slashed revenue guidance by $250 million, underdogs showed up in a big way in Week 10. Those teams went 11-3 against the spread, their best in over seven years. Sportsbooks will be hoping to keep the momentum on their side as they take action on Week 11, highlighted by division matchups like the Commanders vs. Eagles and an AFC championship rematch in the Chiefs vs. Bills.

Below, you can find odds on every game, with analysis on the key NFL betting matchups of Week 11.

NFL Week 11 odds: Spreads moneylines, totals

NFL Week 11 odds: Opening spreads, lines, totals

Thursday Night Football

Commanders vs. Eagles

• Opening spread: Eagles -3
• Opening moneyline: Eagles -185/Commanders +150
• Opening total: 49.5

Week 11 kicks off with a Thursday Night Football matchup between two NFC East rivals clawing for the No. 1 spot in the division. The Eagles (7/2 straight up/5-4 against the spread) opened getting three points at home against the Commanders (7-3 SU/7-2-1 ATS). As of Tuesday, this line is up to Eagles -3.5.

Philadelphia is on a five-game winning streak, thanks to an offense that’s peaking at the right time. Over the last three games, only Detroit and Baltimore have scored more points than the Eagles, who have averaged 33 points per game in that span.

Washington’s offense, meanwhile, is beginning to cool off after a storybook start for rookie quarterback Jayden Daniels. The Commanders are averaging just 24 points over their last three games, after averaging 31 through the first seven weeks of the season. They are coming off a one-point loss to Pittsburgh, their third loss of the season, though six of their seven wins have come against teams with losing records. They will be hoping to reverse that trend Thursday night as they take on a Philly team looking to take hold of the division.

If this line closes below 5.5, it will be the smallest spread in a game between these rivals since 2017.

Sunday games

Ravens vs. Steelers

• Opening spread: Ravens -3
• Opening moneyline: Ravens -165/Steelers +145
• Opening total: 47

Another high-profile matchup with the top spot in the division at stake, the Ravens (7-3 SU/5-4-1 ATS) are getting a field goal on the road against their AFC North rivals, the Steelers (7-2 SU/7-2 ATS).

Both teams, famously reliant on their defenses, are leaning heavily on the other side of the ball as of late, averaging over 30 points in their last three games. Lamar Jackson is the MVP favorite, +110 at BetMGM, after throwing three touchdowns in Week 10’s comeback win against the Bengals.

Pittsburgh has won and covered the spread in each of the last three matchups and is 7-1 straight up against Baltimore since 2020.

Seahawks vs. 49ers

• Opening spread: 49ers -7
• Opening moneyline: 49ers -350/Seahawks +260
• Opening total: 49.5

The 49ers (5-4 SU/4-5 ATS) opened as seven-point favorites against their NFC West rivals, the Seahawks ( SU/2-6-1 ATS), at home. As of Tuesday afternoon, this line is down to 49ers -6.5.

When these teams squared off earlier this season, Deebo Samuel torched Seattle for 117 all-purpose yards, and the 49ers notched a 36-24 win. That was in Seattle, and now the 49ers have running back Christian McCaffrey back in the saddle. McCaffrey totaled 107 all-purpose yards in San Francisco’s 23-20 win against the Buccaneers in Week 10. As -6.5 favorites, they are laying a field goal more than when they last played Seattle, on the road in Week 6.

Seattle is coming off a bye week, hoping to get healthy itself as wide receiver DK Metcalf recovers from an MCL injury that has kept him out since Week 7. The Seahawks sit at the bottom of the division, but winning this game would put them neck-and-neck with San Francisco for second place, just a win behind Arizona.

The 49ers have won each of the last six games in this rivalry, dating back to 2022, and they’ve covered the spread in all but one of those matchups.

Chiefs vs. Bills

• Opening spread: Bills -1.5
• Opening moneyline: Bills -112/Chiefs -104
• Opening total: 46.5

Anytime Josh Allen and Patrick Mahomes square off, it’s sure to draw eyeballs and bettors. Based on early trends at sportsbooks, this is projected to be the most-bet-game of the Sunday slate.

The undefeated Chiefs (9-0 SU/5-4 ATS) opened getting 1.5 points on the road against the Bills (8-2 SU/6-4 ATS), who are looking for their sixth win in a row. As of Tuesday afternoon, this line is up to Bills -2.5. It’s the first time all season that Kanas City opens as an underdog, though the Chiefs have been far from perfect.

Much has been made about close calls and razor-thin victories against Baltimore, Cincinnati, and — most recently — a game-winning blocked field goal against the Denver Broncos. Luck was on Kansas City’s side the last time these two AFC powerhouses squared off in the AFC championship when a field goal that would have tied the game sent the Chiefs on to the Super Bowl.

While Kansas City has been grinding out close-margin wins, Buffalo has put together its eight wins behind the second-biggest point differential in the league. The Bills’ offense has been razor sharp, especially on fourth down, where it ranks No. 1 in conversion. Though their defense, ranked 30th against the rush and 28th in completions allowed, could prove vulnerable to Mahomes and the Chiefs, who are hoping to get No. 1 running back Isiah Pacheco back this week.

Sunday Night Football

Bengals vs. Chargers

• Opening spread: Chargers -1.5
• Opening moneyline: Chargers -120/Bengals +100
• Opening total: 47

The Chargers (6-3 SU/6-3 ATS) open as 1.5-point favorites in their Sunday Night Football matchup against the Bengals (4-6 SU/6-4 ATS).

Los Angeles’ No. 1 ranked defense has carried it through the season as quarterback Justin Herbert works to get fully healthy. The Chargers are holding opponents to a league-low 13.1 points per game on the season and 11.7 during their three-game winning streak. Herbert, meanwhile, is coming off a modest performance stat-wise in Week 10’s win against Tennessee but posted a season-high nine rushes, indicating his ankle is feeling much better.

He’ll face a Bengals defense on Sunday night that ranks 23rd against the pass but has been much more stout against the run, giving up the sixth fewest yards per rush. LA will need Herbert to take advantage of that metric, as it has been among the most run-reliant teams in the NFL this season.

Cincinnati, meanwhile, is playing on extra rest and will be eager for a win after another one-score loss in Week 10. Each of the Bengals’ six losses has been by less than one score, and despite their losing record, they rank in the top half of point differential this season. Joe Burrow should give the Chargers the toughest challenge they’ve had all year, as half of their wins have come against backup quarterbacks. Burrow is red hot coming off a 428-yard, four-touchdown performance against the Ravens, in which he connected 11 times with Ja’Marr Chase, who posted a career-high 264 yards and three touchdowns.