College football Week 6 action begins with a handful of weeknight matchups before a packed Saturday of games. Several of the top 25 teams will be taking the field, including a few ranked-versus-ranked matchups.
Highlights include the Oklahoma vs. Texas annual rivalry game in the early window, and primetime battles of Kentucky at Georgia and Notre Dame taking on Louisville. Read on for a betting preview and a look at the latest and best college football Week 6 odds.
College football Week 6 point spreads
- (12) Oklahoma () at (3) Texas ()
- Maryland () at (4) Ohio State ()
- (23) LSU () at (21) Missouri ()
- (13) Washington State () at UCLA ()
- Virginia Tech () at (5) Florida State ()
- (11) Alabama () at Texas A&M ()
- Syracuse () at (14) North Carolina ()
- (20) Kentucky () at (1) Georgia ()
- (2) Michigan () at Minnesota ()
- (10) Notre Dame () at (25) Louisville ()
- Arkansas () at (16) Ole Miss ()
- Georgia Tech () at (17) Miami ()
- (24) Fresno State () at Wyoming ()
- (15) Oregon State () at California ()
- Arizona () at (9) USC ()
College football Week 6 moneyline odds
- (12) Oklahoma () at (3) Texas ()
- Maryland () at (4) Ohio State ()
- (23) LSU () at (21) Missouri ()
- (13) Washington State () at UCLA ()
- Virginia Tech () at (5) Florida State ()
- (11) Alabama () at Texas A&M ()
- Syracuse () at (14) North Carolina ()
- (20) Kentucky () at (1) Georgia ()
- (2) Michigan () at Minnesota ()
- (10) Notre Dame () at (25) Louisville ()
- Arkansas () at (16) Ole Miss ()
- Georgia Tech () at (17) Miami ()
- (24) Fresno State () at Wyoming ()
- (15) Oregon State () at California ()
- Arizona () at (9) USC ()
College football Week 6 over/under odds
- (12) Oklahoma at (3) Texas ()
- Maryland at (4) Ohio State ()
- (23) LSU at (21) Missouri ()
- (13) Washington State at UCLA ()
- Virginia Tech at (5) Florida State ()
- (11) Alabama at Texas A&M ()
- Syracuse at (14) North Carolina ()
- (20) Kentucky at (1) Georgia ()
- (2) Michigan at Minnesota ()
- (10) Notre Dame at (25) Louisville ()
- Arkansas at (16) Ole Miss ()
- Georgia Tech at (17) Miami ()
- (24) Fresno State at Wyoming ()
- (15) Oregon State at California ()
- Arizona at (9) USC ()
College football Week 6 odds
The odds for this week’s games appear in the table below, which you can adjust to display odds for different types of bets. If you wish to place a wager, just click the appropriate odds to get started. Promos from top sports betting sites are available for new customers.
College football Week 6 betting previews
Oklahoma vs. Texas betting preview
- Date: Saturday, Oct. 7
- Time: 12 p.m. ET
- Broadcast: ABC
- Oklahoma spread:
- Texas spread:
- Oklahoma moneyline:
- Texas moneyline:
- Total: Over/under
The annual Red River Rivalry Game takes place at the Cotton Bowl in Dallas. Oklahoma and Texas both enter at 5-0 and have won all of their games by double digits. The Sooners are ranked 12th in the latest AP poll, while the Longhorns hold down the third spot. This matchup will likely have a big impact on not only the rankings but the hierarchy in the Big 12. Texas took last year’s meeting 49-0, snapping a string of four straight losses to Oklahoma.
Kentucky vs. Georgia betting preview
- Date: Saturday, Oct. 7
- Time: 7 p.m. ET
- Broadcast: ESPN
- Kentucky spread:
- Georgia spread:
- Kentucky moneyline:
- Georgia moneyline:
- Total: Over/under
It’s another meeting of 5-0 ranked teams, this time in the SEC as 20th-ranked Kentucky travels to take on defending champion Georgia, the top-ranked team in the land. The Wildcats defeated Florida in impressive fashion last week, while the Bulldogs had to work to pull out a victory over Auburn. Georgia has won 13 straight over Kentucky and has a 62-12-2 record in all-time meetings.
Notre Dame vs. Louisville betting preview
- Date: Saturday, Oct. 7
- Time: 7:30 p.m. ET
- Broadcast: ABC
- Notre Dame spread:
- Louisville spread:
- Notre Dame moneyline:
- Louisville moneyline:
- Total: Over/under
Notre Dame is ranked 10th in the latest poll with a record of 5-1. The club’s lone defeat was a three-point road loss to Ohio State, and it managed to bounce back with a 21-14 win over Duke last time out. Louisville is a perfect 5-0 and ranked 25th, taking a 13-10 decision at NC State last week. For the season to date, the Fighting Irish are 4-1-1 against the spread and 3-3 on the over/under. The Cardinals check in at 2-3 ATS and 2-2-1 on totals.
College football Week 6 futures report
In the chase for the College Football Playoff, two teams have separated themselves from the pack in current odds. Defending national champion Georgia is the top favorite, with Michigan not too far behind. Ohio State, Texas, and Florida State are jockeying for the third and fourth spots. Behind them are teams like Penn State and Washington.
For the Heisman Trophy race, USC QB Caleb Williams remains the favorite as he aims to win the honor for a second straight season. The Trojans are undefeated, and he has accounted for 24 total TDs to help get them there. Washington QB Michael Penix Jr. has started to close the gap on the odds board as his strong play for the undefeated Huskies continues. Texas QB Quinn Ewers and Oregon QB Bo Nix are next up in the latest odds.
