College football Week 5 action includes primetime matchups on both Thursday and Friday nights, followed by a full Saturday schedule that features many of the top 25 teams.
Featured games include a Pac-12 battle as USC travels to Colorado, an SEC showdown between Georgia and Auburn, and a primetime matchup of Notre Dame at Duke. Read on for a betting preview and a look at the latest and best college football Week 5 odds.
College football Week 5 odds
The odds for this week’s games are in the table below. You can change the type of bet or legal state via the drop-down menus. Click the odds to be directed to the sportsbook offering that line. Promos from top sports betting sites are available for new customers.
College football Week 5 spread odds
Below are the latest point spreads, moneylines, and totals for all of the games featuring top 25 teams, followed by a betting preview for three of this week’s featured matchups.
- (10) Utah () at (19) Oregon State ()
- (6) Penn State () at Northwestern ()
- (8) USC () at Colorado ()
- (22) Florida () at Kentucky ()
- (1) Georgia () at Auburn ()
- (2) Michigan () at Nebraska ()
- (24) Kansas () at (3) Texas ()
- (23) Missouri () at Vanderbilt ()
- (13) LSU () at (20) Ole Miss ()
- (9) Oregon () at Stanford ()
- Iowa State () at (14) Oklahoma ()
- (11) Notre Dame () at (17) Duke ()
- South Carolina () at (21) Tennessee ()
- (12) Alabama () at Mississippi State ()
- (7) Washington () at Arizona ()
- Nevada () at (25) Fresno State ()
College football Week 5 moneyline odds
- (10) Utah () at (19) Oregon State ()
- (6) Penn State () at Northwestern ()
- (8) USC () at Colorado ()
- (22) Florida () at Kentucky ()
- (1) Georgia () at Auburn ()
- (2) Michigan () at Nebraska ()
- (24) Kansas () at (3) Texas ()
- (23) Missouri () at Vanderbilt ()
- (13) LSU () at (20) Ole Miss ()
- (9) Oregon () at Stanford ()
- Iowa State () at (14) Oklahoma ()
- (11) Notre Dame () at (17) Duke ()
- South Carolina () at (21) Tennessee ()
- (12) Alabama () at Mississippi State ()
- (7) Washington () at Arizona ()
- Nevada () at (25) Fresno State ()
College football Week 5 over/under odds
- (10) Utah at (19) Oregon State ()
- (6) Penn State at Northwestern ()
- (8) USC at Colorado ()
- (22) Florida at Kentucky ()
- (1) Georgia at Auburn ()
- (2) Michigan at Nebraska ()
- (24) Kansas at (3) Texas ()
- (23) Missouri at Vanderbilt ()
- (13) LSU at (20) Ole Miss ()
- (9) Oregon at Stanford ()
- Iowa State at (14) Oklahoma ()
- (11) Notre Dame at (17) Duke ()
- South Carolina at (21) Tennessee ()
- (12) Alabama at Mississippi State ()
- (7) Washington at Arizona ()
- Nevada at (25) Fresno State ()
College football Week 5 betting previews
USC vs. Colorado betting preview
- Date: Saturday, Sept. 30
- Time: 12 p.m. ET
- Broadcast: Fox
- USC spread:
- Colorado spread:
- USC moneyline:
- Colorado moneyline:
- Total: over/under
USC takes its perfect 4-0 record on the road this week. The club has scored 40+ points in all four games while winning each by double digits. Colorado dropped to 3-1 with a 42-6 road loss to Oregon on Saturday, silencing a little of the hype that the team has been receiving under head coach Deion Sanders. The Trojans are heavily favored and have won all 16 of their meetings with the Buffaloes, including a 55-17 victory last season.
Georgia vs. Auburn betting preview
- Date: Saturday, Sept. 30
- Time: 3:30 p.m. ET
- Broadcast: CBS
- Georgia spread:
- Auburn spread:
- Georgia moneyline:
- Auburn moneyline:
- Total: over/under
Georgia is 4-0 and remains the favorite to win this season’s national championship. The biggest knock against the two-time defending champ is that it hasn’t been as dominant as many observers were expecting in advance of the campaign. Auburn enters at 3-1, with a 27-10 loss at Texas A&M last time out. The Bulldogs are riding a six-game winning streak over the Tigers, with a victory last season by a score of 42-10.
Notre Dame vs. Duke betting preview
- Date: Saturday, Sept. 30
- Time: 7:30 p.m. ET
- Broadcast: ABC
- Notre Dame spread:
- Duke spread:
- Notre Dame moneyline:
- Duke moneyline:
- Total: over/under
Notre Dame fell to 4-1 with a tough 17-14 road loss to Ohio State on Saturday. The club has fallen to 11th in the latest AP poll and will look to get back on track with another road game against a ranked team. Duke is a perfect 4-0 and ranked 17th. The club has won its four games by double digits, but it’s a home underdog for this one. The Fighting Irish are 3-1-1 against the spread this season, while the Blue Devils check in at 3-1.
College football Week 5 futures report
There has been a shift in the chase for the College Football Playoff. Defending national champion Georgia remains the betting favorite, followed by Michigan holding down the second spot on the board. Florida State and Ohio State are neck-and-neck for the next two places, with Texas, Penn State, and USC behind them.
The race for the Heisman Trophy has tightened up. USC QB Caleb Williams has been the betting favorite since the start of the season, but he’s now in a battle with Washington QB Michael Penix Jr. for the top spot in the latest odds. Williams has 18 total TDs for the 4-0 Trojans, while Penix Jr. has thrown 16 TDs for the 4-0 Huskies.
USC and Washington will meet on Saturday, Nov. 4, in a battle that could have a huge bearing on the Pac-12 standings and the chase for the CFP. Texas QB Quinn Ewers is third in current Heisman odds, followed by Florida State QB Jordan Travis and Oregon QB Bo Nix.
