College Football Week 4 Odds: Current Lines & Betting Preview

It’s another packed slate for college football Week 4. The action gets underway with a handful of primetime matchups on Thursday and Friday, followed by wall-to-wall games on Saturday featuring many of the nation’s top 25 teams. 

Featured games include a Pac-12 showdown between Colorado and Oregon, and a meeting of two top 10 teams under the lights as Ohio State travels to take on Notre Dame. Read on for a betting preview and a look at the latest and best college football Week 4 odds.           

College football Week 4 odds

The odds for this week’s games are listed below. Click the odds to be directed to the sportsbook offering that line. 

• Wisconsin () at Purdue () 
• NC State () at Virginia ()
• Rutgers () at Michigan ()
• Florida State () at Clemson ()
• Oklahoma () at Cincinnati () 
• Auburn () at Texas A&M ()
• SMU () at TCU ()
• Colorado () at Oregon ()
• UCLA () at Utah ()
• Ole Miss () at Alabama ()
• Duke () at UConn ()
• Miami () at Temple ()
• Maryland () at Michigan State ()
• UTSA () at Tennessee ()
• Oklahoma State () at Iowa State ()
• Arkansas () at LSU ()
• Oregon State () at Washington State ()
• Charlotte () at Florida ()
• UAB () at Georgia ()
• Texas () at Baylor ()
• Ohio State () at Notre Dame ()
• Iowa () at Penn State ()
• North Carolina () at Pittsburgh ()
• USC () at Arizona State ()
• California () at Washington ()

College football Week 4 schedule

College football’s Week 4 schedule gets underway with a few games on Thursday and Friday night before the action heats up with a busy Saturday slate. Here’s a look at three of the featured matchups: 

Colorado vs. Oregon betting preview

• Date: Saturday, Sept. 23
• Time: 3:30 p.m. ET
• Broadcast: ABC
• Colorado spread:  
• Oregon spread:
• Colorado moneyline:
• Oregon moneyline:
• Total: Over/under

The most talked about story in the world of college football has been the early season success of Colorado under head coach Deion Sanders. The 19th-ranked Buffaloes take their 3-0 record on the road this week for a Pac-12 showdown with 10th-ranked Oregon, who also enter at 3-0. The Ducks are heavy home favorites for this must-see matchup. 

Ole Miss vs. Alabama betting preview

• Date: Saturday, Sept. 23
• Time: 3:30 p.m. ET
• Broadcast: CBS
• Ole Miss spread:  
• Alabama spread:
• Ole Miss moneyline:
• Alabama moneyline:
• Total: Over/under

Two ranked SEC teams renew their rivalry in Tuscaloosa. Ole Miss is ranked 15th and a perfect 3-0, while Alabama ranks 13th with a record of 2-1, dropping a home game in Week 2 to Texas. The Crimson Tide hold a 58-10-2 advantage in the all-time series, and are riding a seven-game winning streak over the Rebels.  

Ohio State vs. Notre Dame betting preview

• Date: Saturday, Sept. 23
• Time: 7:30 p.m. ET
• Broadcast: NBC
• Ohio State spread:  
• Notre Dame spread:
• Ohio State moneyline:
• Notre Dame moneyline:
• Total: Over/under

Two of the nation’s most storied programs square off under the bright primetime lights in South Bend. Ohio State is ranked sixth and enters at 3-0. QB Kyle McCord has officially been named the starter for the rest of the season. Notre Dame is also 3-0 and ranked ninth. Transfer QB Sam Hartman is off to a fantastic start, racking up 15 total TDs thus far. 

Other notable Week 4 games and odds

In addition to the three featured matchups, there are plenty of other games coming up in Week 4. As always, there are a few paper mismatches on tap, but also several interesting games from a betting perspective. Here are another 10 Saturday college football games and the latest lines for each:   

College football Week 4 futures report

The chase for the College Football Playoff remains in the same shape as last week. Defending champion Georgia is the betting favorite, followed by Michigan, with Texas, Ohio State, and Florida State rounding out the top five. USC, Penn State, and Notre Dame are lurking behind them. 

In the race for the Heisman Trophy, USC QB Caleb Williams remains the favorite and has racked up 13 total TDs for the 3-0 Trojans, but the odds have tightened. Washington QB Michael Penix Jr. holds down second place, followed by Texas QB Quinn Ewers. Next up in the latest odds are Notre Dame QB Sam Hartman, and Florida State QB Jordan Travis.