College Football Week 1 2023: Best Odds & Betting Preview 

College football Week 1 action sees the NCAA season kick into high gear. Play begins Thursday and concludes Monday. In between, there’s a packed schedule with top programs in action, including defending champion Georgia.

Featured matchups include a Saturday primetime battle between West Virginia and Penn State, LSU at Florida State on Sunday, and a Monday night matchup of Duke and Clemson. Let’s begin with a look at the latest and best available college football Week 1 odds.    

College football Week 1 odds

The odds for all FBS games for the upcoming week are in the table below. You can change the type of bet via the drop-down menu. If you wish to place a wager, click the odds to get started. Promos from top sports betting sites are available for new users. 

College football Week 1 schedule

The college football season kicked off last Saturday with a handful of games. The schedule ramps up this week with dozens of games from Thursday to Monday night. Here’s a look at three of the featured matchups. 

West Virginia vs. Penn State betting preview 

• Date: Saturday, Sept. 2
• Time: 7:30 p.m. ET
• Broadcast: NBC
• West Virginia spread:
• Penn State spread:
• West Virginia moneyline:
• Penn State moneyline:
• Total: Over/under

West Virginia closed out last season with a record of 5-7, missing out on a bowl game as a result. The Mountaineers have 13 returning starters, with Garrett Greene and Nicco Marchiol battling for the QB1 role. Penn State enters as the seventh-ranked team in the nation and could compete for the Big Ten crown. Sophomore Drew Allar appears to be the likely choice to take over under center.    

LSU vs. Florida State betting preview 

• Date: Sunday, Sept. 3
• Time: 7:30 p.m. ET
• Broadcast: ABC
• LSU spread:
• Florida State spread:
• LSU moneyline:
• Florida State moneyline:
• Total: Over/under

Camping World Stadium in Orlando is the neutral-site home for this battle of top 10 programs. LSU is ranked fifth to begin the season, with Florida State holding the eighth spot. The teams met in the opening week of last season, as well, with the Seminoles holding off a furious comeback attempt by the Tigers to exit with a 24-23 victory. 

Clemson vs. Duke betting preview 

• Date: Monday, Sept. 4
• Time: 8 p.m. ET
• Broadcast: ESPN
• Clemson spread:
• Duke spread:
• Clemson moneyline:
• Duke moneyline:
• Total: Over/under

The final game of the week is a primetime showdown of ACC rivals. Clemson ranks No. 9 overall and is looking to defend its conference crown. The club has been on the outside looking in at the College Football Playoff two seasons in a row. Duke closed out last season with a record of 9-4 and a bowl game win over UCF. The Tigers have won their last five meetings with the Blue Devils. 

Other notable Week 1 games and odds

Beyond the trio of games above, plenty of other contests will take place. While there are several mismatches of powerhouses taking on lesser programs, there are still some interesting games from a betting perspective. Here are a dozen Saturday college football games for bettors to consider:   

College football Week 1 futures report

In the chase for the College Football Playoff, the top of the odds board consists of familiar names. Defending national champion Georgia is the favorite to take the crown once again, with Alabama up next. Big Ten rivals Ohio State and Michigan round out the top four. 

USC quarterback Caleb Williams is the current betting favorite to win the Heisman Trophy. He helped lead the Trojans to a 56-28 win over San Jose State last week, throwing for 278 yards and four touchdowns along the way. Next up in the latest lines are Texas QB Quinn Ewers and LSU QB Jayden Daniels.