Week 17 NFL Odds: Opening Spreads, Moneylines, Totals

NFL betting odds are available for Week 17, another critical late-season slate that features plenty of marquee matchups with important postseason implications. 

LSR offers the latest odds from top sportsbooks along with a quick-hitting NFL betting preview for Week 17 games.

NFL Week 17 odds: Spreads, moneylines, totals

NFL Week 17 opening spreads, lines, totals

NFL Week 17 game odds and analysis 

Kansas City Chiefs (-2.5) at Pittsburgh Steelers (+2.5)

The Chiefs disposed of the Houston Texans on Saturday to keep control of their final playoff positioning. A victory in this Christmas Day clash against the Steelers would clinch the top seed in the AFC for KC and home field advantage throughout the postseason. The Chiefs got a little healthier Saturday with the season debut of Hollywood Brown, who made a solid impact with five catches for 45 yards.

The Steelers have lost two straight to put their quest for the AFC North crown in peril. Their latest stumble came in Week 16 against the arch-rival Ravens, although each of those defeats has been without George Pickens (hamstring) available. The Steelers’ No. 1 receiver reportedly has a strong chance of returning for this game, and that would certainly give an offense that’s been struggling without him a serious boost.

The Chiefs are 3-2 ATS as road favorites this season, while the Steelers are 2-0 with an impressive ATS +/- of +14.8 points as home underdogs.

This game opened with an over/under of 43.0 points.

Baltimore Ravens (-3.5) at Houston Texans (+3.5)

The Ravens got the best of the Steelers on Saturday afternoon, with Lamar Jackson conquering one of his career-long obstacles with 207 passing yards and three touchdowns. Meanwhile, Derrick Henry turned in a signature 162-yard effort on the ground, while Zay Flowers hit the 100-yard mark through the air.

Houston’s offense indeed suffered a significant loss in Saturday’s 27-19 defeat at the hands of the Chiefs when Tank Dell sustained a dislocated kneecap on a touchdown reception. The Texans are now down to Nico Collins in terms of the stellar “big three” receiving corps they opened the season with, as Stefon Diggs has been sidelined for the season due to an ACL tear for several weeks. 

The Ravens are 5-2 against the number as road favorites this season, while the Texans are 1-0 as home underdogs and 2-2-1 ATS following a loss.

This game opened with an over/under of 47.0 points.

Seattle Seahawks (-3.5) at Chicago Bears (+3.5)

The Seahawks dropped a crucial 27-24 decision to the Vikings in Week 16, putting them a game behind the Rams in the NFC West. Seattle also saw Kenneth Walker’s return from a two-game absence cut short by an ankle injury that could leave his chances of playing on a short week very slim. However, Zach Charbonnet is on hand to provide starter-quality production and would be in a good spot against this vulnerable Bears run defense.

The Bears suffered their ninth straight loss via a 34-17 defeat at the hands of the Lions, although Caleb Williams continued his curious personal streak during that time period of not throwing a single interception in those games. The rookie first overall pick also eclipsed the 300-yard mark and looked sharp overall, offering Thomas Browns’ squad some hope against what has proven to be a vulnerable Seattle secondary at times. 

The Seahawks are 0-0-1 as road favorites this season, while the Bears are 1-1-1 against the number when they’ve been home underdogs.

The game has opened with an over/under of 43.5 points.

Los Angeles Chargers (-4.5) at New England Patriots (+4.5)

The Chargers got past the Broncos by a 34-27 score on Thursday night in Week 16 to draw even with Denver in the standings at 9-6. Los Angeles was able to run an impressively balanced offense against the Broncos’ tough defense, and the matchup on the ground is an especially enticing one in this cross-country matchup. Gus Edwards led the ground attack with a pair of rushing TDs in the win, and J.K. Dobbins has now had his practice window opened to give him a chance to be activated from injured reserve in time for this game. 

The Patriots gave the Bills all they could handle in Week 16 before falling by a 24-21 score. Drake Maye continues to look the part of a first-round pick and future of the franchise, and New England’s mix of young players and veterans may be finally starting to gel a bit as the season winds down. This game presents another opportunity to play a bit of spoiler against a playoff contender, and the weather advantage certainly would project to be on Jerod Mayo’s squad’s side.

The Chargers have handled road-favorite status well, going 3-1 ATS in that split. The Pats are 2-3-1 as home underdogs. Los Angeles is also 1-0 when playing with a rest advantage, while New England has yet to play with a rest disadvantage this season.

The game has opened with an over/under of 42.5 points.

Denver Broncos (+3) at Cincinnati Bengals (-3)

The Broncos saw a four-game winning streak snapped on Thursday Night Football with a close 34-27 loss to the Chargers. While that was what in recent times could be labeled a rare loss for Denver, it was a costly one, as it robbed Sean Payton’s club of clinching a playoff spot. That raises the stakes for this Saturday afternoon showdown, considering the Bengals kept themselves alive for a postseason berth with a win over the Browns on Sunday. 

Cincinnati, meanwhile, took care of business against an overmatched Cleveland team that started Dorian Thompson-Robinson at quarterback. Joe Burrow continued his spectacular season with another three touchdown passes, pushing the Bengals ever closer to .500 at 7-8. This essentially shapes up as another elimination game for Cincy, which is notably a three-point home favorite despite Denver outpacing the Bengals by two wins on the season.

The Broncos are 4-2 ATS as road underdogs, while the Bengals are only 2-4 against the spread as home favorites yet 4-0 ATS when playing with a rest disadvantage.

This game opened with an over/under of 48.5 points.

Arizona Cardinals (+6) at Los Angeles Rams (-6)

The Cardinals suffered multiple losses in Week 16 against the Panthers. Not only did they take a 36-33 defeat in overtime to get knocked out of playoff contention, but James Conner had his knee twisted in the third quarter in the midst of what was shaping up to be an elite all-around performance. Arizona may opt to tread cautiously now that the postseason is out of reach.

The Rams, on the other hand, kept themselves right in the thick of the NFC playoff picture with grindy 19-9 cross-country road win over the Jets. Los Angeles’ defense continued to demonstrate late-season improvement and the combination of the Rams’ fourth straight win and the Seahawks’ loss to the Vikings gave Sean McVay’s club sole possession of first place at 9-6.

For all their late-season flailing, the Cardinals are a noteworthy 4-1 ATS as road underdogs. The Rams are 0-2 against the number as home favorites.

The game has opened with an over/under of 48.5 points.

Tennessee Titans (+1) at Jacksonville Jaguars (-1)

The Titans pivoted to Mason Rudolph at quarterback in Week 16 following his productive second half in fill-in duty the Sunday prior. The results were mixed, as Tennessee fell by a 38-30 score in a game Rudolph was able to toss a couple of TDs in but three picks as well. Nevertheless, head coach Brian Callahan has already announced he’ll stick with the veteran, who did produce several big gains through the air, for this matchup.

The Jaguars’ Mac Jones put together a solid performance in his own right against the Raiders, compiling 247 yards and a touchdown in Jacksonville’s loss. Brian Thomas Jr. has shown some nice chemistry with his one-time fellow first-round pick and posted a 9-132-1 line that gives team brass and fans alike optimism for the future once Trevor Lawrence is back to full health. 

The Titans are just 2-6 ATS as road underdogs this season, although that mark is accompanied by a respectable ATS +/- of -3.9 points. The Jaguars are just 0-2 ATS in the rare instances they’ve been home favorites. Tennessee and Jacksonville are 1-3 and 2-1-1 against the number, respectively, in division games.

The first meeting between the teams resulted in a 10-6 win for the Jaguars.

The game has opened with an over/under of 41 points.

Carolina Panthers (+8) at Tampa Bay Buccaneers (-8)

The Panthers continued to cultivate optimism for 2025 with another late-season win, and it was an especially meaningful one considering it knocked a conference rival out of playoff contention. Carolina’s 36-33 overtime win over the Cardinals not only showed grit on the part of the Panthers but also saw Bryce Young bounce back from a four-turnover performance against the Cowboys a week prior to post a clean game. Dave Canales’ club has a chance to continue its spoiler tour in this matchup against a Bucs team fighting to remain atop the NFC South.

Tampa Bay got itself into a predicament by losing to the Cowboys, 26-24, on Sunday night. The secondary continued to struggle without Antoine Winfield, giving up 292 passing yards and a touchdown to Cooper Rush. The Bucs can ill afford another slip-up in this spot considering that Atlanta, which they’re tied with at 8-7 in the standings, holds the tie-breaker over Tampa Bay by virtue of their season sweep.

The Panthers are 2-4 ATS as road underdogs and 2-2 in division games, while the Bucs are 2-1 ATS as home favorites and only 1-3 against the number versus NFC South foes. The first meeting between the teams accounts for part of the latter mark, as the Bucs squeaked out a 26-23 victory in overtime back in Week 13.

The game has opened with an over/under of 49.5 points.

Indianapolis Colts (-7.5) at New York Giants (+7.5)

The Colts road the coattails of Jonathan Taylor to the tune of his 218 rushing yards and three touchdowns to get past the Titans in Week 16 by a 38-30 score. Anthony Richardson attempted just 11 passes and was effective in that small sample, and although concerns remain about his long-term viability as a starter, this is another beatable matchup for the second-year signal-caller.

The Giants fell by an embarrassing 34-7 score to the Falcons on the road in what was their 10th straight loss. Drew Lock committed another trio of turnovers, and he’s now dealing with a shoulder injury that could endanger his ability to suit up in this game. New York’s talented rookie tandem of Tyrone Tracy and Malik Nabers continue to be about the only bright spots for Big Blue down the stretch and do have solid outlooks on paper in this matchup. 

The Colts are 0-2 ATS as road favorites this season and 1-3 against the number in non-conference games. The Giants hold the same record when facing AFC opponents and are an ugly 2-6 ATS as home underdogs.

The game has opened with an over/under of 40.5 points.

Las Vegas Raiders (-1.5) at New Orleans Saints (+1.5)

The Raiders got Aidan O’Connell back on the field in a Week 16 win over the Jaguars and saw the second-year signal-caller deliver a solid 257-yard tally through the air. Brock Bowers continued his spectacular rookie season with a 11-catch, 99-yard outing that pushed him over the 100-catch and 1,000-yard marks, and he’ll undoubtedly continue to serve as O’Connell’s top target over the final two games. 

The Saints were handed an ugly 34-0 loss by the Packers on Monday night that saw Spencer Rattler hang tough but ultimately fall well short of succeeding with a significant undermanned offense. The rookie is gaining valuable reps, however, but it remains to be seen if Derek Carr (hand) will be able to make it back for this matchup against his old squad. Alvin Kamara (groin), who missed Week 16, is also attempting to suit up again this season despite New Orleans being out of the playoff hunt.

This line will undoubtedly shift if either or both of Carr and Kamara are announced as available, but for now, Vegas has flipped from slight road underdog to narrow road favorite. Las Vegas has yet to enter a game with that status this season and is 1-2-1 ATS in non-conference games along with an 0-2 mark vs. the spread when playing with a rest advantage.

Meanwhile, the Saints are 3-3 ATS as home underdogs, 1-3 against AFC foes and 2-2 against the number when playing with a rest disadvantage.

The game has opened with an over/under of 40 points.

New York Jets (+10) at Buffalo Bills (-10)

The Jets’ offense mostly turned back into a pumpkin after a rousing Week 15 showing as New York fell to the Rams by a 19-9 score in Week 16. Aaron Rodgers did put together another solid stat line that included 256 passing yards and a TD, but he simply couldn’t lead Gang Green to enough points and lost a fumble. Rodgers is now dealing with an MCL injury but says he intends to suit up for this divisional clash.

The Bills surprisingly gave up 379 total yards to the Patriots in a scary 24-21 win that Buffalo had to fight and claw for four quarters in. Nevertheless, Josh Allen and company remain the AFC’s second-best team behind the Chiefs and will look to avoid a second straight letdown against an inferior opponent as they sharpen up for a highly anticipated postseason run.

The Jets are 1-1 ATS as road underdogs and 2-2 in division games. The Bills hold a 4-3 mark as home favorites and 2-2 record in division games as far as the spread. The first meeting between the team resulted in a 23-20 Bills win at MetLife Stadium. 

The game has opened with an over/under of 46.5 points.

Dallas Cowboys (+9.5) at Philadelphia Eagles (-9.5)

The Cowboys continue their late-season surge in Week 16 even as they were officially eliminated from playoff contention. Dallas upended a Buccaneers team in desperate need of a win, recording a 26-24 victory that saw Cooper Rush continue to impress with 292 passing yards and the defense come away with a critical late fumble recovery. Dallas is now 7-8 and could be well on its way to earning Mike McCarthy a new contract in his lame-duck season. 

The Eagles had quite the unpleasant Week 16, blowing a double-digit second-half lead to lose by a 36-33 score to the Commanders. Additionally, Jalen Hurts (concussion) was knocked out of the game and will have to clear protocol to play this week, while Kenny Pickett was solid as a fill-in but came away with a rib injury of his own. The status of both will be one to watch throughout the week, and in the meantime, Philly is now a game behind both Detroit and Minnesota for the NFC’s top seed.

The Cowboys are solid 4-2 with an ATS +/- of +9.5 points as a road underdog and 2-2 in division games. The Eagles are only 2-4 ATS as home favorites but 3-1 against the number in division games (ATS +/- of +9.9).

Philly had no trouble with Dallas in the first meeting (34-6) back in Week 10, but this game could certainly have markedly different results if Hurts and Pickett are both out.

The game has opened with an over/under of 43 points.

Miami Dolphins (-6.5) at Cleveland Browns (+6.5)

The Dolphins, behind De’Von Achane’s first 100-yard performance (17-120-1) of the season and an additional 70 receiving yards, remained alive in the AFC wild-card picture while knocking the 49ers out of playoff contention with a 29-17 win in Week 16. Jaylen Waddle (knee) missed the game for Miami and missed the first practice of the week Wednesday, so it appears there’s a 50/50 chance at minimum a second straight absence is in the cards.

The Browns’ offense with Dorian Thompson-Robinson at the controls in Week 16 wasn’t very successful from a points perspective, but the second-year quarterback had his moments while displaying particularly impressive chemistry with David Njoku (8-66 line on 10 targets). Jerome Ford was even better in his first game back in the lead-back role (131 total scrimmage yards) but the entire offense will run into a talented and incentivized defense in this late season clash.

The Dolphins are just 2-5 ATS as road favorites this season, while the Browns are 2-4 as home underdogs.

The game has opened with an over/under of 40 points.

Green Bay Packers (+1.5) at Minnesota Vikings (-1.5)

The Packers will close out the Week 16 slate with a Monday Night Football battle at frigid Lambeau Field against the undermanned Saints, led by rookie Spencer Rattler. Green Bay is 10-4 heading into the contest, and even with a win, it’ll still be two games back of both the Lions and Vikings in the NFC North. However, Green Bay is in the driver’s seat for a wild-card spot, yet it undoubtedly would love to put a crimp in Minnesota’s quest for the conference’s No. 1 seed.

The Vikings kept themselves in the running for that distinction with a gutsy road win over the Seahawks on Sunday. Minnesota thus kept pace with co-division leader Detroit at 13-2, with the two teams set to face off in Week 18. Sam Darnold and Justin Jefferson continued to hone their late-season connection versus Seattle to the tune of 10 connections for 144 yards and two touchdowns, keeping them just as dangerous as the Goff-St. Brown battery. 

The Packers are 2-0 against the spread as road underdogs this season and 1-3 ATS in division games. The Vikes are 3-2 ATS as home favorites and 2-1-1 against the number versus NFC North foes. Green Bay has yet to play at a rest disadvantage this season, while Minnesota is 2-1 against the number when playing with a rest edge in 2024.

This game opened with an over/under of 48.5 points.

Atlanta Falcons (+5) at Washington Commanders (-5)

The Atlanta Falcons opened the Michael Penix era with a win against the visiting Giants, besting New York by a 34-7 score. Penix did not look out of place whatsoever while throwing for 207 yards, and he got plenty of help from Bijan Robinson (94 rush yards, two TDs). Drake London exited the game in the second half with a hamstring injury but will reportedly be ready to roll for this key matchup that Atlanta must win to keep itself in the running for the NFC South title.

The Commanders will likely come into this matchup brimming with confidence after coming back from a multi-score deficit against the Eagles and escaping with a 36-33 victory. Jayden Daniels threw a career-high five touchdown passes to push Washington to a 10-5 record and keep it in the running for the NFC East title. 

The Falcons are 1-2 ATS as road underdogs with a bloated ATS +/- of -13.0 points. The Commanders are 5-2 against the number as home favorites.

This game opened with an over/under of 46.5 points.

Detroit Lions (-3.5) at San Francisco 49ers (+3.5)

The Lions were able to move to 13-2 with a 34-17 win over the hapless Bears at Soldier Field in Week 16. Detroit managed just fine without David Montgomery (knee) in the first game of his rest-of-regular-season absence, with Jahmyr Gibbs accounting for 154 total yards and a rushing touchdown on 27 touches. Dan Campbell’s squad needs to keep winning to maintain pace with the Vikings, who are also 13-2, ahead of a Week 18 showdown between the teams that could decide the NFC’s No. 1 seed.

The Niners were knocked out of playoff contention with a 29-17 loss to the Dolphins in Week 16, a game rookie running back Isaac Guerendo missed with hamstring and foot injuries. Guerendo is expected to open the practice week as a limited participant at minimum, giving him a chance to return from a one-game absence and try and help San Francisco throw a wrench in Detroit’s postseason goals.

The Lions are a stellar 5-1 ATS as road favorites this season with an ATS +/- of +11.1 points in that split. The 49ers will be playing as home underdogs for the first time this season and are 4-4 against the number following a loss. 

The game has opened with an over/under of 51.5 points.