Week 12 College Football Odds: Spreads, Moneylines & Totals

Week 12 college football odds signal an action-packed slate, with plenty on the line as teams look to solidify their spot in the 12-team playoff.

A primetime showdown between top 10 Tennessee and Georgia headlines Saturday, while Oregon looks to stay perfect against Wisconsin. Elsewhere, Colorado will try to keep its Big 12 title hopes alive against Utah, and LSU will aim to bounce back against Florida.

Here’s a breakdown of the latest college football betting odds and what’s on the line in Week 12’s major matchups.

Week 12 college football odds: Spreads, moneylines & totals

Week 12 college football odds: Opening spreads, moneylines & totals

Tennessee vs. Georgia

• Opening spread: Georgia -8.5
• Opening moneyline: Georgia -380/Tennessee +290
• Opening total: 53.5

No. 11 Georgia (7-2 straight up/2-7 against the spread) opens as an 8.5-point favorite against No. 6 Tennessee (8-1 SU/5-4 ATS) ahead of their primetime matchup on Saturday, the only top-10 on top-10 game of the week.

This game is critical for both teams, who hope to hold on to a spot in the 12-team playoff. Depending on how the rest of the conference plays out, another loss could sputter either SEC team out of the picture entirely. Georgia racked up its second loss of the season in Week 11, losing to Ole Miss 28-10, while Tennessee enjoyed a bye week after beating Florida 23-17 in Week 10.

Georgia’s defense has been stalwart, holding opponents to 18 points per game. However, quarterback Carson Beck has struggled and is leading the conference in interceptions. It won’t get any easier against a Tennessee defense that has not allowed more than 20 points in a game this season.

Oregon vs. Wisconsin

• Opening spread: Oregon -14.5
• Opening moneyline: Oregon -750/Wisconsin +475
• Opening total: 52.5

No. 1 Oregon (10-0 SU/5-5 ATS) opens as a 14.5–point favorite versus unranked Wisconsin (5-4 SU/3-6 ATS) in Madison.

This is tied — with a road game against Michigan in Week 2 — for the fewest points Oregon has been favored by all season. The Ducks won that matchup by 21 points, and they enter this matchup after a 39-18 home win against Maryland.

A loss here would likely keep the Ducks in the playoff race, though it would likely see them fall out of the top spot. Conversely, another close win, like their three-point victory against Boise State, would still keep them as the nation’s only undefeated Power Four team, making it tough for the committee to move them down.

Wisconsin is coming off a bye week after a 42-10 loss to Iowa in Week 10. The Badgers will be looking to play the role of spoiler against Oregon, a team they haven’t beaten since 2000. They have had a tough time up front defensively, where they rank in the bottom of the conference in sacks and tackles for a loss, and have instead relied on their secondary.

Utah vs. Colorado

• Opening spread: Colorado -10
• Opening moneyline: Colorado -425/Utah +320
• Opening total: 48.5

No. 10 Colorado (7-2 SU/7-2 ATS) opens this contest against Utah (4-5 SU/3-6 ATS) as a 10-point favorite at home.

Coach Prime’s squad still has a shot at the College Football Playoff, and another big win here could prove critical to its chances. At second place in the Big 12, with the conference winner slated for an automatic bid, the Buffaloes will look to roll over a Utah team that has routinely shot itself in the foot. The Utes have lost each of their last five games, all by 13 points or fewer.

The Buffaloes, on the other hand, have been hitting on all cylinders thanks to two-way star Travis Hunter and potential No. 1 overall draft choice Shedeur Sanders. They have not so quietly won six of their last seven, as Sanders has thrown 24 touchdowns and Hunter has widened his lead as the odds-on Heisman favorite.

Colorado’s defense has been no slouch, either, holding opponents to 22.6 points per game. That should prove a tough challenge for a Utah offense that is averaging 14.2 points over its last five games.

Clemson vs. Pittsburgh

• Opening spread: Clemson -9.5
• Opening moneyline: Clemson -400/Pittsburgh +300
• Opening total: 54.5

No. 23 Clemson (7-2 SU/5-4 ATS) opens this matchup as a 9.5-point road favorite against the higher-ranked No. 18 Pittsburgh (7-2 SU/6-3 ATS).

Clemson still has a shot at the 12-team playoff with a realistic path to the ACC title still in front of it. The Tigers play a Pittsburgh team coming off two straight losses that may again be without its starting quarterback. The Panthers’ offense carried them to their 7-0 start but has dragged them down in their losses, managing just 22 points per game over the last two weeks.

The Tigers are coming off a 24-14 win against Virginia Tech, though their offense has sputtered lately as well, averaging just 22.5 points over the last two weeks. It’s instead been their defense that’s led the way, holding opponents to 14 points or fewer in four out of their last six conference games.

LSU vs. Florida

• Opening spread: LSU -4
• Opening moneyline: LSU -200/Florida +170
• Opening total: 55.5

No. 15 LSU (6-3 SU/3-6 ATS) opened as a four-point favorite against Florida (4-5 SU/5-4 ATS). As of Tuesday evening, that line had moved to LSU -5.

Both teams are coming off blowout losses against conference opponents and have lost their last two games. LSU is still licking its wounds after a 42-13 home loss to Alabama, while Florida is looking to bounce back at home after losing 49-17 to Texas in Austin.

Florida has proved formidable with DJ Lagway under center. Unfortunately for the Gators, he has not always been available. According to reports, he is questionable for this matchup.

The Tigers, meanwhile, came back down to earth after winning six straight. They will be looking to get after recent backslides on both sides of the ball. Without much of a running game, quarterback Garrett Nussmeier has been key to moving the ball, but he’s thrown five interceptions in his last two games. The defense, meanwhile, has slipped to 13th in the conference after a hot start to the season.