March Madness Odds: Sweet 16 Spreads, Moneylines, And Totals For Every Game


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March Madness continues with Sweet 16 action on Thursday and Friday. The first two rounds have been filled with thrills and upsets. We could be in store for even more of both as the rest of the tournament plays out. 

Betting odds for the Sweet 16 are available at March Madness online sportsbooks. Read on for a detailed look at what’s on tap and the best available odds for every game.  

Jump to region: East | West | South | Midwest

Best NCAA Tournament odds: Sweet 16

East Region odds

Sweet 16 action for the East Region will take place on Thursday night at TD Garden in Boston. Many brackets were busted in the opening round when Yale upset Auburn. Meanwhile, Illinois and Iowa State have managed to handle business, with both squads picking up double-digit wins in their two games to advance. Top-seeded UConn had little trouble picking up wins over Stetson and Northwestern.

MatchupFavoriteTotal
3 Illinois vs. 2 Iowa StateIowa State
1 UConn vs. 5 San Diego St.UConn

West Region odds

The West Region Sweet 16 games will be Thursday night at Crypto.com Arena in Los Angeles. The biggest upset on this side of the ledger happened in the opening round when Grand Canyon took down Saint Mary’s. North Carolina and Arizona have justified their lofty seeds, with both squads pulling out victories of 10-plus points in first- and second-round action. 

MatchupFavoriteTotal
1 North Carolina vs. 4 AlabamaNorth Carolina
2 Arizona vs. 6 ClemsonArizona

South Region odds

Sweet 16 games for the South Region will tip off on Friday night at American Airlines Center in Dallas. No. 11 NC State has continued its hot run to advance. After ripping off five straight victories to win the ACC tourney, the club has continued its winning ways with victories over Texas Tech and Oakland. No. 1 Houston needed overtime to get past Texas A&M on Sunday.

MatchupFavoriteTotal
11 NC State vs. 2 MarquetteMarquette
4 Duke vs. 1 HoustonHouston

Midwest Region odds

Friday’s other pair of Sweet 16 tilts will be for the Midwest Region at Little Caesars Arena in Detroit. This bracket has gone according to form for the most part, with seeds 1-8 advancing through the first round. On Saturday, Creighton survived a scare from Oregon, needing two overtimes to get the win. Meanwhile, top-seeded Purdue has outscored its two opponents by a combined 67 points.

MatchupFavoriteTotal
3 Creighton vs. 2 TennesseeTennessee
5 Gonzaga vs. 1 PurduePurdue

Explore March Madness odds

There are more ways to wager on March Madness beyond the Sweet 16. LegalSportsReport covers various ways to bet on the NCAA Tournament, including the following options:

March Madness Sweet 16 betting preview

Clemson vs. Arizona

No. 6 Clemson has advanced to the Sweet 16 in the West Region with victories over New Mexico and Baylor. The Tigers entered March Madness on a two-game skid with a record of 21-11. No. 2 Arizona entered the dance with a mark of 25-8 and having dropped two of its last three. The Wildcats have defeated Long Beach State and Dayton in the first two rounds.

San Diego State vs. UConn

San Diego State is the fifth seed in the East Region. The Aztecs have advanced with victories over UAB and Yale after entering the tournament with a record of 24-10. They’ll be squaring off with top-seeded UConn, the defending national champions. The Huskies have cruised through the first two rounds with convincing victories over Stetson and Northwestern.

Alabama vs. North Carolina

No. 4 Alabama has advanced to the Sweet 16 in the West Region following wins over Charleston and Grand Canyon. The Crimson Tide closed out the campaign at 21-11 after dropping four of their last six. Top-seeded North Carolina was upset by NC State in the ACC tournament final, but they’ve managed to bounce back in March Madness with convincing victories over Wagner and Michigan State.

Illinois vs. Iowa State 

Illinois is the third seed in the East and has advanced with convincing victories over Morehead State and Duquesne. The club entered the tournament with a record of 26-8 and riding a four-game winning streak. No. 2 Iowa State took down South Dakota State and Washington State to advance. The Cyclones closed out the campaign by winning three straight to get to 27-7.  

NC State vs. Marquette

NC State is the 11th seed in the South Region. After taking down Texas Tech in the opener, they defeated Oakland in overtime to advance to the Sweet 16. The Wolfpack have won seven straight as they get set to take on No. 2 Marquette. The Golden Eagles defeated Western Kentucky in round one, and followed with a four-point win over Colorado in the second round.

Gonzaga vs. Purdue

Gonzaga is the fifth seed in the Midwest Region. The Bulldogs have defeated both McNeese and Kansas by double digits to make it to the Sweet 16. No. 1 Purdue has bounced back in a big way from its surprising exit in the semi-finals of the Big Ten Tournament. The Boilermakers defeated Grambling 78-50 in its opener, and followed with a 106-67 win over Utah State.

Duke vs. Houston

No. 4 Duke has racked up a pair of convincing wins over Vermont and James Madison to advance to the Sweet 16 of the South Region. The Blue Devils were on a two-game skid heading into the tournament, including an upset loss to NC State in the ACC tourney. No. 1 Houston opened with a big win Longwood in round one, but needed overtime to advance over Texas A&M in the second round.

Creighton vs. Tennessee

Creighton is the third seed in the Midwest. After a double-digit win over Akron in its opening game, it had a much tougher time in the second round before exiting with a victory over Oregon in double overtime. No. 2 Tennessee blew by Saint Peter’s in the opener and followed with a 62-58 win over Texas.