Best NCAA March Madness Odds: Second Round Spreads, Moneylines, And Totals For Every Game

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The 2024 March Madness tournament is on to the second round after a first round that was littered with upsets and surprises. March Madness online sportsbooks have released betting odds on every second round game in the NCAA Tournament.

Below, we’ll look at the best available odds on every game in the second round of the March Madness tournament.

Jump to region: East | West | South | Midwest

Best NCAA Tournament odds: Second round

East Region odds

The big surprise in the East so far was the elimination of No. 6 BYU at the hands of No. 11 Duquesne. The first two games of the second round in this region will take place in Omaha on March 23, followed by games in Spokane and Brooklyn on March 24.

11 Duquesne vs. 3 IllinoisIllinois (-10) – Won and covered147 – Over hits
7 Washington State vs. Iowa StateIowa State (-6.5) – Won and covered128 – Under hits
1 UConn vs. 9 NorthwesternUConn (-15.5) – Won and covered131.5 – Over hits
5 San Diego St vs. 13 YaleSan Diego State (-5.5) – Won and covered129 – Over hits

West Region odds

The top two West Region seeds — North Carolina and Arizona — are both through to the second round. The first two games are set for Charlotte and Salt Lake City on March 23, with the next two taking place in Spokane and Memphis on March 24.

1 North Carolina vs. 9 Michigan StateNorth Carolina (-3.5) – Won and covered142.5 – Over hits
7 Dayton vs. 2 ArizonaArizona (-9) – Won and covered149 – Under hit
12 Grand Canyon vs. 4 AlabamaAlabama (-5) – Won and covered172.5 – Under hits
6 Clemson vs. 3 BaylorBaylor (-4.5) – Lost and did not cover146 – Under hits

South Region odds

The South has already seen some upsets, with No. 14 Oakland pulling off the biggest shock of the tournament to send Kentucky packing. No. 11 NC State also knocked off No. 6 Texas Tech on Thursday. Those two squads will kick off the second round in Pittsburgh on March 23.

11 NC State vs. 14 OaklandNC State (-6) – Won and pushed147.5 – Over hits
1 Houston vs. 9 Texas A&MHouston (-8) – Won and did not cover135.5 – Over hits
12 JMU vs. 4 DukeDuke (-6) – Wond and covered147.5 – Over hits
10 Colorado vs. 2 MarquetteMarquette (-4.5) – Won and did not cover150.5 – Over hits

Midwest Region odds

Things have mostly played out according to chalk in the Midwest so far, with the exception of No. 11 Oregon beating No. 6 South Carolina in the first round. All but one of the second round-games in this region will go down on March 23.

5 Gonzaga vs. 4 KansasGonzaga (-3.5) – Won and covered152 – Over hits
11 Oregon vs. 3 CreightonCreighton (-4) – Won and covered146 – Over hits
7 Texas vs. 2 TennesseeTennessee (-6.5) – Won and did not cover145 – Under hits
1 Purdue vs. 8 Utah StatePurdue (-9.5) – Won and covered150 – Over hits

Explore March Madness odds

There are more ways to wager on March Madness beyond the second round. LegalSportsReport covers various ways to bet on the NCAA Tournament, including the following options:

March Madness second round betting preview

Oakland vs. NC State

Oakland pulled off the biggest upset of the tournament so far, beating No. 3 Kentucky 80-76 on Thursday night. Jack Gohlke became the early story of March Madness, sinking 10 3-pointers in the win — one shy of the tournament record — while finishing with 32 points in the game.

NC State also advanced with an upset victory, beating no. 6 Texas Tech 80-67 in the first round. Ben Middlebrooks led the Wolfpack in scoring with 21 points, and NC State continued the winning streak that carried it to the ACC Tournament title.

Michigan State vs. North Carolina

Michigan State cruised to a 69-51 win over No. 8 Mississippi State in the first round. Guards Tyson Walker and Jaden Akins combined for 34 points and 10 rebounds in the victory.

Top-seeded North Carolina made easy work of No. 16 Wagner with a 90-62 thumping to open the tournament. RJ Davis led the Tar Heels with 22 points. North Carolina is among the top 10 favorites to reach the Final Four.

Dayton vs. Arizona

Dayton beat No. 10 Nevada 63-60 on Thursday night to advance to the second round. DaRon Holmes scored 18 points while collecting nine rebounds in the victory.

Arizona rolled past No. 15 Long Beach State 85-65 in the first round. Kylan Boswell led scorers with 20 points, while Caleb Love added 18 points and 11 rebounds.