The 2024 March Madness tournament is on to the second round after a first round that was littered with upsets and surprises. March Madness online sportsbooks have released betting odds on every second round game in the NCAA Tournament.
Below, we’ll look at the best available odds on every game in the second round of the March Madness tournament.
Jump to region: East | West | South | Midwest
Best NCAA Tournament odds: Second round
East Region odds
The big surprise in the East so far was the elimination of No. 6 BYU at the hands of No. 11 Duquesne. The first two games of the second round in this region will take place in Omaha on March 23, followed by games in Spokane and Brooklyn on March 24.
| Matchup | Favorite | Total |
| 11 Duquesne vs. 3 Illinois | Illinois (-10) – Won and covered | 147 – Over hits |
| 7 Washington State vs. Iowa State | Iowa State (-6.5) – Won and covered | 128 – Under hits |
| 1 UConn vs. 9 Northwestern | UConn (-15.5) – Won and covered | 131.5 – Over hits |
| 5 San Diego St vs. 13 Yale | San Diego State (-5.5) – Won and covered | 129 – Over hits |
West Region odds
The top two West Region seeds — North Carolina and Arizona — are both through to the second round. The first two games are set for Charlotte and Salt Lake City on March 23, with the next two taking place in Spokane and Memphis on March 24.
| Matchup | Favorite | Total |
| 1 North Carolina vs. 9 Michigan State | North Carolina (-3.5) – Won and covered | 142.5 – Over hits |
| 7 Dayton vs. 2 Arizona | Arizona (-9) – Won and covered | 149 – Under hit |
| 12 Grand Canyon vs. 4 Alabama | Alabama (-5) – Won and covered | 172.5 – Under hits |
| 6 Clemson vs. 3 Baylor | Baylor (-4.5) – Lost and did not cover | 146 – Under hits |
South Region odds
The South has already seen some upsets, with No. 14 Oakland pulling off the biggest shock of the tournament to send Kentucky packing. No. 11 NC State also knocked off No. 6 Texas Tech on Thursday. Those two squads will kick off the second round in Pittsburgh on March 23.
| Matchup | Favorite | Total |
| 11 NC State vs. 14 Oakland | NC State (-6) – Won and pushed | 147.5 – Over hits |
| 1 Houston vs. 9 Texas A&M | Houston (-8) – Won and did not cover | 135.5 – Over hits |
| 12 JMU vs. 4 Duke | Duke (-6) – Wond and covered | 147.5 – Over hits |
| 10 Colorado vs. 2 Marquette | Marquette (-4.5) – Won and did not cover | 150.5 – Over hits |
Midwest Region odds
Things have mostly played out according to chalk in the Midwest so far, with the exception of No. 11 Oregon beating No. 6 South Carolina in the first round. All but one of the second round-games in this region will go down on March 23.
| Matchup | Favorite | Total |
| 5 Gonzaga vs. 4 Kansas | Gonzaga (-3.5) – Won and covered | 152 – Over hits |
| 11 Oregon vs. 3 Creighton | Creighton (-4) – Won and covered | 146 – Over hits |
| 7 Texas vs. 2 Tennessee | Tennessee (-6.5) – Won and did not cover | 145 – Under hits |
| 1 Purdue vs. 8 Utah State | Purdue (-9.5) – Won and covered | 150 – Over hits |
Explore March Madness odds
There are more ways to wager on March Madness beyond the second round. LegalSportsReport covers various ways to bet on the NCAA Tournament, including the following options:
March Madness second round betting preview
Oakland vs. NC State
Oakland pulled off the biggest upset of the tournament so far, beating No. 3 Kentucky 80-76 on Thursday night. Jack Gohlke became the early story of March Madness, sinking 10 3-pointers in the win — one shy of the tournament record — while finishing with 32 points in the game.
NC State also advanced with an upset victory, beating no. 6 Texas Tech 80-67 in the first round. Ben Middlebrooks led the Wolfpack in scoring with 21 points, and NC State continued the winning streak that carried it to the ACC Tournament title.
Michigan State vs. North Carolina
Michigan State cruised to a 69-51 win over No. 8 Mississippi State in the first round. Guards Tyson Walker and Jaden Akins combined for 34 points and 10 rebounds in the victory.
Top-seeded North Carolina made easy work of No. 16 Wagner with a 90-62 thumping to open the tournament. RJ Davis led the Tar Heels with 22 points. North Carolina is among the top 10 favorites to reach the Final Four.
Dayton vs. Arizona
Dayton beat No. 10 Nevada 63-60 on Thursday night to advance to the second round. DaRon Holmes scored 18 points while collecting nine rebounds in the victory.
Arizona rolled past No. 15 Long Beach State 85-65 in the first round. Kylan Boswell led scorers with 20 points, while Caleb Love added 18 points and 11 rebounds.
