Arizona Cardinals Odds

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The Arizona Cardinals open the regular season at home with a tough test. The Kansas City Chiefs, one of the current top five favorites to win the Super Bowl, are coming to town for one of the featured games of the late Sunday slate of Week 1 games on Sept. 11.

After a hot start last year, the Cardinals struggled down the stretch and were one and done in the postseason. During the offseason, questions emerged on the franchise’s relationship with star QB Kyler Murray, though the matter appears resolved for the time being.

Arizona is in the middle of the pack of Super Bowl contenders and projects to have its work cut out in the competitive NFC West. Current odds for the Week 1 matchup have the Chiefs as 3-point road favorites with the over/under at 53 points. Here’s a closer look at the lines, futures and props.

Arizona Cardinals odds: Spread, moneyline and over/under

Week 1 odds: Arizona Cardinals underdogs vs. Kansas City Chiefs

The Chiefs made it to the AFC title game last season before falling to the Cincinnati Bengals. The Cardinals fell in the wild card round to the eventual Super Bowl champion Los Angeles Rams.

As home underdogs for the opener, Arizona will have some extra motivation to get the season started on the right foot and put last year’s rough finish behind them.

  • Moneyline: As Week 1 home underdogs, the Cardinals moneyline opened at +130 against the Chiefs.
  • Spread: Kansas City is among the favorites to reach the Super Bowl and opened as a field goal favorite (-3, -115) for this game.
  • Over/Under: The 53-point total is currently the highest of Week 1. The Chiefs averaged 28.2 points per game last year, fourth in the NFL, while the Cardinals were 11th at 26.4.

Cardinals odds to win the Super Bowl

Last updated: June 30

DraftKings released futures odds for 2023 Super Bowl in January 2022. The Cardinals were at +2500 to win the Super Bowl, or 13th among the 32 NFL teams. The current odds are at +3500 with Arizona slipping to 16th in the rankings.

Based on the odds, online sportsbooks expect the Cardinals to be in the mix of playoff contenders this season, but they’re a few steps behind the league’s elite. The Buffalo Bills and Tampa Bay Buccaneers are the current Super Bowl favorites.

Arizona Cardinals futures odds for 2022-23

While the Super Bowl is the star attraction in NFL futures markets, there are plenty of other bets on how the Cardinals season will play out. Let’s take a look at a sampling of the team’s odds.

Regular Season Win Total

DraftKings Sportsbook: Over 9 (-110) / Under 9 (-110)

Last year, the Cardinals started out hot at 7-0 before cooling off and finishing up at 11-6. For perspective on offseason benchmarks, DraftKings has listed just 10 teams with a win total of 10 or more.

Odds to win NFC West

BetMGM Sportsbook: +270

The Cardinals have the third-best odds to win the division at BetMGM. The Rams are the top choice at +150, followed by the 49ers at +200. The Seahawks are expected to finish in last place with current odds of +900.

Odds to win NFC

Caesars Sportsbook: +1300

Over at Caesars, the Cardinals are currently sixth on the odds board to win the NFC. The Buccaneers are the current favorites at +350, followed by the Packers at +475 and the Rams at +500.

Kyler Murray NFL MVP odds

FanDuel Sportsbook: +2000

Murray returns behind the center to lead the way for the potent Cardinals offense. He’s currently tied for 10th in MVP odds at FanDuel. Josh Allen and Patrick Mahomes are the top choices at +700, followed by Tom Brady at +800.

Season-long player prop odds

DraftKings Sportsbook

  • Most passing yards: Kyler Murray +2000
  • Most rushing yards: James Conner +6000
  • Most receiving yards: DeAndre Hopkins +2000

For last season, Murray was 14th in passing yards with 3,787. Conner was a TD machine, but he only racked up 752 yards on the ground. Hopkins had 572 receiving yards in an injury-shortened campaign.

Arizona Cardinals schedule

WeekDateOpponentKickoffSpreadMoneylineTotal
1Sept. 11vs. KC4:25 p.m. ETKC -3Chiefs (-150), Cardinals (+130)53 pts
2Sept. 18@ ARI4:25 p.m. ET
3Sept. 25vs. LAR4:25 p.m. ET
4Oct. 2@CAR4:05 p.m. ET
5Oct. 9vs. PHI4:25 p.m. ET
6Oct. 16@SEA4:05 p.m. ET
7Oct. 20vs. NO8:20 p.m. ET
8Oct. 30@MIN1 p.m. ET
9Nov. 6vs. SEA4:05 p.m. ET
10Nov. 13@ LAR4:25 p.m. ET
11Nov. 21vs. SF (in Mexico City)8:15 p.m. ET
12Nov. 27vs. LAC4:05 p.m. ET
13Dev. 4BYEBYEBYEBYEBYE
14Dec. 12vs. NEP8:15 p.m. ET
15Dec. 18@ DEN4:05 p.m. ET
16Dec. 25vs. TB8:20 p.m. ET
17Jan. 1@ ATL1 p.m. ET
18Jan. 7 OR Jan. 8@SFTBD

Latest news and updates 

NFL free agency was a busy time for the Cardinals. The team re-upped with some key pieces, including James Conner and Zach Ertz, but also lost a few cogs such as Chandler Jones and Christian Kirk. The team also made some moves to bolster the offensive line and defense. New arrivals in Arizona include Jeff Gladney and Will Hernandez.

At the NFL Draft, the Cardinals made a big splash in round one, but not due to a pick that they made. The club shipped its first-rounder to the Baltimore Ravens in exchange for wideout Marquise Brown. The Arizona offense was among the league’s best for much of last season. The addition of Brown could make it that much more potent.

Arizona Cardinals FAQ

Are the Cardinals a Super Bowl contender?

It’s unlikely that the Cardinals will be in the Super Bowl this season. The current futures market odds for the Cardinals are +3500 at DraftKings and +2700 at FanDuel. That leaves them below the top tier of teams, but in the mix of expected playoff contenders.

How did the Cardinals do against the spread last season?

Including the postseason, the Cardinals were 10-8 against the spread a season ago and 11-7 on the moneyline. As for totals, the club skewed slightly towards the under with a final mark of 8-10.

Who did the Cardinals add and lose in the offseason?

During free agency, Chandler Jones and Christian Kirk were among the names moving on to greener pastures, while players including Jeff Gladney and Will Hernandez joined the team. At the NFL Draft, Arizona traded its first-round pick to Baltimore in exchange for wide receiver Marquise Brown.

Is Kyler Murray staying in Arizona?

Early in the offseason, there were some rumblings that the franchise’s relationship with its starting QB was starting to fracture. Naturally, there was plenty of scuttlebutt in the media as a result, but the matter has been put to rest for the time being. Arizona picked up the fifth-year option on Murray’s contract, which will keep him in town through at least the 2023 NFL season.

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