The Kansas City Chiefs (5-0) come out of their bye week for a road game at the San Francisco 49ers (3-3) that will headline Week 7 action. Kickoff will be 4:25 p.m. ET this Sunday, and Fox has the broadcast.
These teams have met in the Super Bowl in 2020 and 2024 and have combined to appear in 10 conference championship games since 2019.
The Chiefs have won 11 straight games dating back to last season, and Andy Reid is 21-3 after a bye in his coaching career. Despite that track record, the Chiefs are slight underdogs on the point spread and even on the moneyline (+100) in NFL Week 7 odds. The over/under line is at 47.5 points.
The 49ers are on a bit of extra rest after dispatching the Seattle Seahawks on Oct. 10. They will still be without Christian McCaffrey (Achilles), and capable replacement Jordan Mason is questionable with a shoulder sprain.
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Chiefs vs. 49ers spread, moneyline, & total
Player props for Chiefs vs. 49ers
How Travis Kelce could get over 59.5 receiving yards
The Kansas City Chiefs are down several key weapons with Rashee Rice (ACL) out for the year to go along with Marquise Brown (shoulder) and Isiah Pacheco (tibia) being on injured reserve. Any plans the defending champs had to rest Kelce for the second half of the year are on hold after those injuries, and the veteran tight end responded to an increased workload with 16 catches for 159 yards over his last two outings.
Kelce caught nine of 10 targets for 93 yards against the 49ers in the Super Bowl last February, and he has routinely stepped up in big regular season games. The Niners could be thin at safety if rookie Malik Mustapha (ankle) is unable to play. Even in a regularly quiet campaign, Kelce still ranks fifth in target share (21.1%) and second in air yard share (24.7%) among tight ends.
How Travis Kelce could get under 59.5 receiving yards
Kelce is likely to draw even more attention in this matchup since the rest of the Chiefs’ receiving corps is limited or unproven. The San Francisco 49ers have the best coverage linebacker in football and a legitimate Defensive Player of the Year candidate in Fred Warner. They’ve only allowed 25 receptions and 200 yards to tight ends through six games, both of which rank top 10 among NFL defenses.
The Chiefs offense is coming off a great performance against an injury-riddled Saints team, but Patrick Mahomes is not playing up to his lofty standards, as the Chiefs are completing 53% of their passes, which ranks 20th in the NFL. Kansas City has become a defensive-minded team, and that could impact the game flow in this contest.
How Deebo Samuel could score an anytime touchdown
Books are offering odds as long as +115 for Samuel to find the end zone in this matchup. He broke a three-game scoreless streak with a 76-yard touchdown reception against Seattle and opened the season with a two-yard rushing TD against the Jets. Increased rushing production makes Samuel an atypical receiver, giving him multiple ways to find the end zone.
If Jordan Mason (shoulder) is out, the Niners should use Samuel as a runner on 10-plus snaps as he splits time with backup Isaac Guerendo. The Chiefs’ defensive line is tough to beat on the interior, where Chris Jones dominates, but Samuel can run around the edge toward the pylon to get it done in tight red zone situations.
How Deebo Samuel could miss an anytime touchdown
The over/under line in this game is 47.5 points, and touchdowns could certainly be hard to come by given the quality of each defense. The Chiefs are only allowing 1.8 touchdowns per game and are holding opponents to a 46.7% success rate in terms of converting red zone possessions into touchdowns.
Facing the Chiefs in the Super Bowl last year, Samuel caught just three of 11 targets for 33 yards, and Trent McDuffie remains one of the best cornerbacks in the league. With an extra week to plan, the Chiefs could be ready when Samuel lines up in the backfield or comes in motion to take a potential handoff from the edge.