The NFL heads into Week 6 of the season, and betting lines are appearing across legal sportsbooks in the US
. Week 6 is highlighted by a showdown between two of the best teams in the league as the Kansas City Chiefs
host the Buffalo Bills
on Sunday afternoon.
In this article, we provide current NFL Week 6 spreads, moneylines, and totals, along with key storylines to keep in mind before placing bets.
Analysis will be added as news develops.
NFL Week 6 opening odds
Week 6 best odds and betting breakdown
Washington Commanders at Chicago Bears
- Spread: Commanders
- Moneyline: Commanders
What a (disappointing) way to kick off Week 6! On the bright side, it’s only uphill after last week’s Broncos/Colts debacle on Thursday Night Football.
The Bears (2-3) and Commanders (1-4) lost close games in Week 5. Washington is a rare favorite against a Bears team that ranks last in nearly every offensive passing category and runs the football at the highest percentage in the league. Stopping the run is one of the few areas the Commanders have excelled this year.
Betting markets exist for this game, of course, but it might not make for quality viewing.
Patriots at Browns
- Spread: Patriots
- Moneyline: Patriots
continues to impress. After stepping up in relief and taking the Packers to overtime two weeks ago, Zappe and the Pats demolished the Lions, 29-0, in Week 5. It’s unclear who will start at QB for New England this week, but we know it will either be Zappe or Mac Jones
, as Brian Hoyer
is on IR.
The Browns fell to 2-3 with a 30-28 loss to the Chargers. Once again, Cleveland was gashed on the ground, this time for 238 yards and a pair of touchdowns. The Browns face another run-heavy offense in Week 6 but enter as home favorites.
San Francisco 49ers at Atlanta Falcons
- Spread: 49ers
- Moneyline: 49ers
The frisky Falcons covered the spread again in Week 5 as 10-point underdogs to the Bucs. Atlanta is 5-0 against the spread this season despite winning just two of those games. They return home as sizable home underdogs to the 49ers, who routed the Carolina Panthers in Week 5.
New York Jets at Green Bay Packers
- Spread: Jets
- Moneyline: Jets
The Packers travel back to the States with their tail between their legs after losing outright as eight-point favorites to the Giants. Green Bay failed to find consistency on offense, generating only 206 yards through the air against a poorly rated Giants pass defense. The Packers own the same record as the Jets (3-2), who piled up 40 points in a blowout win over the Dolphins on Sunday. Green Bay still opened as a big favorite in Lambeau.
Jacksonville Jaguars at Indianapolis Colts
- Spread: Jaguars
- Moneyline: Jaguars
Who are the real Jacksonville Jaguars? The team that dominated the Colts and Chargers earlier in the year has now lost two in a row, including a home game to the Texans in Week 5. Despite producing 422 yards of offense, the Jags only had a pair of field goals to show for it on the scoreboard. They’ll hope to right the ship in Week 6 against a stingy Colts defense.
The Colts were without Jonathan Taylor
in Week 5 but still managed to pull out an ugly win over the Broncos on Thursday Night Football. Taylor is expected to return this week, but injuries continue to mount for Indianapolis (Nyheim Hines
, Ryan Kelly
, Kwity Paye
are questionable for Week 6.)
Minnesota Vikings at Miami Dolphins
- Spread: Vikings
- Moneyline: Vikings
The nightmare continues for the Miami Dolphins.
With Tua Tagovailoa
already sidelined with a concussion, backup QB Teddy Bridgewater
was hit hard in the first quarter and ruled out for the rest of the game under the league’s new concussion protocol. That left seventh-round rookie Skylar Thompson
to fill in, and he was understandably unimpressive in what turned out to be a runaway win for the New York Jets. Tyreek Hill
also left the game with a foot injury; oddsmakers and bettors will be watching Miami’s injury reports closely ahead of the Week 6 game against Minnesota.
Cincinnati Bengals at New Orleans Saints
- Spread: Bengals
- Moneyline: Bengals
With Jameis Winston
still out, the Saints used a two-headed QB of Andy Dalton
and Taysom Hill
to run up 39 points against the Seahawks. The QB situation remains murky heading into the Week 6 game against the Bengals. Cincinnati lost on a last-second field goal to the Baltimore Ravens on Sunday Night Football.
Baltimore Ravens at New York Giants
- Spread: Ravens
- Moneyline: Ravens
Many used the word “fraud” to describe the Giants as they entered Week 5 with a 3-1 record. But after beating Aaron Rodgers and the Packers in London, is it time to start taking New York seriously? The Giants held Aaron Rodgers and the Packers to 4.7 yards per play, another stout performance by the defense to support their run-heavy offense.
That said, the Giants will still enter Week 6 as home underdogs to the Ravens. Baltimore defeated Cincinnati on Sunday Night Football in Week 5, so this line could move on that result.
Tampa Bay Buccaneers at Pittsburgh Steelers
- Spread: Bucs
- Moneyline: Bucs
The Bucs hit the gas early against the Falcons, jumping out to a 21-0 lead, and survived a late scare to escape with a 21-15 win. For the second straight game, Tom Brady
threw 50-plus times for more than 350 yards. This is a different offense when Brady has Mike Evans and Chris Godwin in the lineup.
The Steelers, meanwhile, showed their frustration with several on-field skirmishes against the Bills in an embarrassing 38-3 loss. Kenny Pickett
threw for 327 yards in his first career start, but most of that was empty yardage in garbage time. It won’t get much easier for Pickett against Tampa in Week 6.
Carolina Panthers at Los Angeles Rams
- Spread: Panthers
- Moneyline: Panthers
Glaring issues on the Rams offensive line have been exposed numerous times this season. The Cowboys were the latest to take advantage, sacking Matthew Stafford
four times and applying pressure all day in a victory. That dropped the defending champion Rams to 2-3 on the season.
The Rams are favored at home in Week 6 because Panthers have their own offensive issues, starting at QB. Baker Mayfield
completed only 20 of 36 passes and was replaced by PJ Walker in a lopsided loss to the 49ers in Week 5.
Arizona Cardinals at Seattle Seahawks
- Spread: Cardinals
- Moneyline: Cardinals
was brilliant again, throwing for 268 yards and three TDs on only 25 attempts against the Saints in Week 5, but he was let down by his defense in a 39-32 loss. The Seahawks defense allowed 235 yards on the ground on 48 carries, including 112 to “tight end” Taysom Hill. Seattle has now scored 103 total points in the past three weeks but only has one win to show for it.
The Cardinals had an opportunity in Week 5 to be the first to defeat the Eagles this season, but Matt Ammendola missed a 43-yard field goal to tie the game late in the fourth. Kyler Murray’s
offense stalled most of the way; Arizona is counting down the days until DeAndre Hopkins
returns to the lineup.
Buffalo Bills at Kansas City Chiefs
- Spread: Bills
- Moneyline: Bills
The main course on the Week 6 slate takes place at Arrowhead Stadium. This is a rematch of last year’s epic Divisional Round playoff classic that saw the Chiefs tie the game late before winning 42-36 in overtime. This game has surely been circled by Josh Allen
, who was nearly perfect in that playoff game but watched Patrick Mahome
s march down the field in OT to secure the win.
The Chiefs host the Raiders on Monday Night Football in Week 5, so they’ll have a short week to prepare for Buffalo.
Dallas Cowboys at Philadelphia Eagles
- Spread: Cowboys
- Moneyline: Cowboys
The Eagles remain unbeaten and sit as home favorites to the division rival Cowboys for Sunday Night Football. The matchup to watch here is the Eagles’ sturdy but banged-up offensive line against the Cowboys’ pass rush, although an apparent injury to Micah Parsons
will be worth watching for the Cowboys this week.
Also worth monitoring is the status of Dak Prescott
, who could return to the Dallas lineup. Cooper Rush is 4-0 in Prescott’s absence.
Denver Broncos at Los Angeles Chargers
- Spread: Broncos
- Moneyline: Broncos
The Broncos get extra time to rest a prepare for this Monday Night Football showdown, and they’ll need it. Russell Wilson
reportedly played with a partially torn lat muscle near his throwing shoulder in Week 5, which might account for the failures in Denver’s passing offense the past two weeks. Wilson will receive an injection and is expected to play against the Chargers.
Los Angeles got a hard-fought victory over the Browns in Week 5 behind a massive game on the ground from Austin Ekeler
. The Broncos will present a much tougher defensive challenge on Monday Night Football. Denver has yielded only 16 points per contest through five games.