NFL Week 5 odds have been posted by oddsmakers. The first four weeks have given NFL fans numerous close games and last-minute heroics, but the Week 5 slate features several games with big spreads, potentially setting up the first week of the season with multiple walkovers.
The week kicks off on Thursday with one of the tighter spreads of the week between the Denver Broncos and Indianapolis Colts. An AFC West showdown between the Kansas City Chiefs and Las Vegas Raiders will close out the week on Monday Night Football.
In this article, we look at current NFL Week 5 spreads, totals and moneylines at legal US sportsbooks.
NFL Week 5 opening odds
Week 5 best odds and betting breakdown
Indianapolis Colts at Denver Broncos
- Spread: Colts , Broncos
- Moneyline: Colts , Broncos
The Colts fell to 1-3 after a 24-17 loss to the Titans. The Colts dominated in the box score, outgaining the Titans by more than a yard per play, but once again turnovers plagued Matt Ryan. The Colts handed the ball over three times, bringing the season total to nine. Another potential loss could be to Jonathan Taylor, who left the game with an ankle injury.
A costly fumble by Melvin Gordon that was returned for a TD set the tone for the Broncos in a loss to Las Vegas on Sunday. The Broncos otherwise looked solid, outgaining the Raiders by nearly a yard per play.
New York Giants at Green Bay Packers
- Spread: Giants , Packers
- Moneyline: Giants , Packers
Somehow the Giants are 3-1 despite sitting near the bottom of the NFL in numerous statistical metrics. None of the victories were overly impressive and came against the lowly Panthers, Titans, and Bears. Now they head to Green Bay with both Daniel Jones and Tyrod Taylor dealing with injuries. This line opened -7.5 on the look-ahead but could climb quickly if both QBs are ruled out.
The Packers were favored by 9.5 at home against a New England team that was without its starting quarterback. Then, in the first quarter, the Patriots lost their backup QB to injury, leaving third-stringer Bailey Zappe taking snaps for most of the game. Still, the Packers struggled to take advantage.
Pittsburgh Steelers at Buffalo Bills
- Spread: Steelers , Bills
- Moneyline: Steelers , Bills
The Kenny Pickett era is underway in Pittsburgh, and it has already been a wild ride. The Steelers looked poised to beat the Jets in Week 4 behind a courageous Pickett rushing score, but a late interception by the rookie QB paved the way for a Jets comeback win.
Pickett will likely get the start in Week 5 against the 3-1 Bills, who opened as huge home favorites. Buffalo looked shaky in Baltimore on Sunday but Jordan Poyer picked off Lamar Jackson in the end zone to set up a game-winning drive for the Bills.
LA Chargers at Cleveland Browns
- Spread: Chargers , Browns
- Moneyline: Chargers , Browns
The Chargers looked like what we all thought the Chargers would be in 2022, although it did come against the Texans. With Justin Herbert healing and Keenan Allen expected to return soon, this offense could be dangerous again in the near future.
The Browns lost as road favorites to the Falcons in Week 4, mostly because they couldn’t stop anything on the ground. Missing two key pieces on the defensive line doens’t help. Myles Garrett is expected to miss a couple more weeks following his car accident.
Chicago Bears at Minnesota Vikings
- Spread: Bears , Vikings
- Moneyline: Bears , Vikings
The Vikings escaped with the victory in the United Kingdom to get to 3-1 on the season, keeping them in sole possession of first place in the NFC North (tiebreaker over Green Bay). They should be able to hold that lead with a Week 5 showdown against Chicago as sizeable home favorites.
The Bears were held to 12 points against the Giants in Week 4 behind only 11 completions by Justin Fields. Chicago seems determined to pound the football on the ground even without lead RB David Montgomery; the Bears ran the ball 32 times in Week 4.
Detroit Lions at New England Patriots
- Spread: Lions , Patriots
- Moneyline: Lions , Patriots
Another week, another Detroit Lions barnburner. The Lions scored 45 points against Seattle in Week 4 but surrendered 48, bringing their record to 1-3. In a year in which scoring is down across the league, Detroit has allowed an average of 35.25 per game. That’s by far the most in the league.
On the bright side, the Lions next face a New England team that could be starting Bailey Zappe at quarterback this week if both Mac Jones and Brian Hoyer can’t go.
Seattle Seahawks at New Orleans Saints
- Spread: Seahawks , Saints
- Moneyline: Seahawks ,
The Saints have a long trip home to think about their wild loss to the Vikings. Will Lutz drilled a 60-yard field goal to tie the game late, but he doinked a 65-yard attempt that would’ve sent the game to overtime. Still, the Saints should be happy with the performance considering they were without Jameis Winston, Michael Thomas and Alvin Kamara. All three could return for the Week 5 game against Seattle.
Seattle piled up 48 points against Detroit but faces a much tougher task in Week 5. The Seahawks averaged 8.8 yards per play in Week 4; the Saints are allowing only 5 per play for the season.
Miami Dolphins at New York Jets
- Spread: Dolphins , Jets
- Moneyline: Dolphins , Jets
There’s no timetable for a Tua Tagovailoa return after the Dolphins QB was carted off the field with a concussion on Thursday Night Football. That leaves Teddy Bridgewater as the backup plan as Miami travels on the road in Week 5. The line moved to Dolphins after Tua was officially ruled out on Monday.
The Comeback Jets did it again, winning their second game of the season on the final drive against Pittsburgh. Zach Wilson struggled at times in his first start of the year, completing only 18 of 36 passes, but he threw for a score and even caught one in the victory. He will be under center again in Week 5 against his division rival.
Atlanta Falcons at Tampa Bay Buccaneers
- Spread: Falcons , Bucs
- Moneyline: Falcons , Bucs
Atlanta moved to 2-2 despite completing only seven forward passes against the Browns on Sunday. They ran all over the Browns to the tune of 202 yards on 35 carries, and the defense forced a pair of turnovers. That was enough to get the win.
The Bucs couldn’t get a stop against the Chiefs in Week 4, which is cause for concern for a defense that had looked dominant early in the year. But the offense seems to be rounding into form with the return of Mike Evans, Chris Godwin, and Julio Jones to the lineup. Tom Brady threw for 385 yards and three touchdowns in the loss, although some of that game was in garbage time.
The Bucs have a much more generous game script ahead of them in Week 5.
Tennessee Titans at Washington Commanders
- Spread: Titans , Commanders
- Moneyline: Titans , Commanders
After opening the season with a pair of ugly losses, the Titans are back to .500 and right in the thick of the AFC South race. Getting back to basics, Derrick Henry ran for 100-plus yards for the second straight week. The Titans impressed again, forcing three turnovers and holding Jonathan Taylor to 42 yards on 20 carries.
Washington, meanwhile, never sniffed a victory against Dallas. Carson Wentz threw two INTs and took two sacks. That could actually be looked at as a positive after Wentz was sacked a total of 14 times in Weeks 2 and 3. He’ll likely see a lot of pressure In Week 5 against a Titans front that has been surprisingly capable at getting to the QB.
Houston Texans at Jacksonville Jaguars
- Spread: Texans , Jaguars
- Moneyline: Texans , Jaguars
The Texans put up another tough fight in Week 4 but ultimately fell to the Chargers, 34-24. Despite failing to win a game this season, the Texans have a negative point margin of only 20.
Houston travels to Jacksonville to face a 2-2 Jags team that blew a 14-point lead to the Eagles in Week 4. The Jags led 14-0 in the first quarter but failed to score again until late in the fourth. Still, Jacksonville has proven that it can play with the league’s best.
San Francisco 49ers at Carolina Panthers
- Spread: 49ers , Panthers
- Moneyline: 49ers , Panthers
The Panthers defense looked great again in Week 4, holding Kyler Murray and the Cardinals to 4.8 yards per play, but Baker Mayfield turned it over three times and generated only 197 yards through the air. Christian McCaffrey gained 27 yards on eight carries. The Panthers need to find chemistry on offense, especially with the 49ers next on the schedule.
San Francisco’s defense looked dominant again on Monday Night against the Rams, and the offense did enough to run away with an easy victory. The Week 5 matchup against Carolina sets up as a favorable one against the turnover-happy Mayfield.
Dallas Cowboys at LA Rams
- Spread: Cowboys , Rams
- Moneyline: Cowboys , Rams
The Cowboys are now 3-0 without Dak Prescott under center, but it’s fair to credit their defense for a lot of that success. Prescott could return to the lineup in Week 5, but if not, Cooper Rush has done enough to earn a starting gig every week in the league.
The Rams played against a hard-hitting Niners team on Monday Night Football and will have a short week to prepare for the Cowboys. The Rams offensive line had trouble containing the 49ers front, allowing seven sacks, and the matchup in the trenches doesn’t get a whole lot easier against Dallas.
Philadelphia Eagles at Arizona Cardinals
- Spread: Eagles , Cardinals
- Moneyline: Eagles , Cardinals
Philadelphia is the last unbeaten team of 2022. In the rain on Sunday, the Eagles ran for 210 yards and four scores and kept Jacksonville’s pass-rushers at bay for most of the game. Philly can score in many different ways and present a tough test for all comers this year.
The Eagles head to Arizona favored by more than a field goal. Kyler Murray’s weapons are getting healthier, but Murray faces his toughest challenge of the season against a top-ranked defense.
Cincinnati Bengals at Baltimore Ravens
- Spread: Bengals , Ravens
- Moneyline: Bengals , Ravens
Cincinnati has ripped off two wins in a row after starting 0-2 and now gets some extra rest to prepare for division-rival Baltimore. Joe Burrow is coming off his best start of the year, averaging 9.3 yards per attempt in the win over Miami on Thursday. Next up is Baltimore’s defense which ranks among the worst at defensing the pass through four weeks.
The Ravens had their chances to beat the Bills in Week 4 but gave the game away in a high-leverage situation late in the fourth quarter. A sloppy contest benefited the run-heavy Baltimore squad but the Ravens still failed to close it out.
Las Vegas Raiders at Kansas City Chiefs
- Spread: Rainders , Chiefs
- Moneyline: Raiders , Chiefs
The Raiders finally got a victory on Sunday with a victory over Denver. It wasn’t pretty, but Derek Carr led a convincing drive in the fourth quarter to put the game out of reach. It was a big win for Vegas before heading to Arrowhead in Week 5. The Chiefs had their way with the Bucs in Week 4.