Oddsmakers have released opening lines for NFL Week 4, and there are several outstanding matchups on the slate.
Two Super Bowl favorites face off on Sunday Night Football when the Tampa Bay Buccaneers host the Kansas City Chiefs, and one night later, the defending champion LA Rams visit the San Francisco 49ers on Monday Night Football.
In this article, you’ll find current Week 4 NFL odds from legal US sportsbooks, along with key storylines and betting insights for every matchup.
Analysis will be added as news develops.
NFL Week 4 opening odds
Week 4 best odds and betting breakdown
Miami Dolphins at Cincinnati Bengals
- Spread: Dolphins , Bengals
- Moneyline: Dolphins , Bengals
The Dolphins won a thriller against Buffalo in Week 3 to take sole possession atop the AFC East standings. Miami’s defense allowed another huge game through the air, giving up 400 yards to Josh Allen, but strung together some big stops in the red zone to secure a late win. The Dolphins face another high-powered passing offense in Week 4.
Bengals fans can take their finger off the panic button. Cincinnati finally found the win column, but it did come against the lowly Jets. After throwing four interceptions in the first two games, Joe Burrow kept that column clean in the 27-12 win over New York. He has a short week to prepare for Miami’s blitz-heavy attack.
Minnesota Vikings vs. New Orleans Saints
- Spread: Vikings , Saints
- Moneyline: Vikings , Saints
Things were looking bleak for the Vikings late against Detroit in Week 3, but timely turnovers and a late Kirk Cousins TD to KJ Osborn got the Vikings a much-needed win over the division rival Lions. Dalvin Cook left the game in the second half with a shoulder injury; his status will be worth watching this week, but Alexander Mattison is a serviceable replacement.
Despite throwing for 353 yards, Jameis Winston was ineffective for most of Week 3’s loss to the Panthers. He threw two more INTs, bringing his season total to five. At 1-2 and facing a potential playoff contender in Week 4, the Saints are under pressure for a win as they travel to the United Kingdom to face the Vikes.
Cleveland Browns at Atlanta Falcons
- Spread: Browns , Falcons
- Moneyline: Browns , Falcons
As a road favorite, Cleveland has a good opportunity to get to 3-1 in the standings before heading into the meat of its schedule, beginning with the Chargers next week. Jacoby Brissett has been serviceable filling in for Deshaun Watson, throwing four touchdowns and only one INT while the Browns running backs have gashed the opposition on the ground.
The Falcons won their first game of the year in Week 3 against Seattle. Atlanta possesses several talented young weapons on offense and they’ll need big performances from them against this Cleveland defense.
Washington Commanders at Dallas Cowboys
- Spread: Commanders , Cowboys
- Moneyline: Commanders , Cowboys
Washington’s offense sputtered against the Eagles in Week 3 after putting up 55 points total in the first two weeks. Carson Wentz’s offense averaged only 3.2 yards per play against Philly in a 24-8 loss.
The assignment gets easier in Week 3 against a Dallas team still without Dak Prescott. But Cooper Rush is now 2-0 as a starter for Dallas this season, and oddsmakers are adjusting for his competency as a quarterback.
Seattle Seahawks at Detroit Lions
- Spread: Seahawks , Lions
- Moneyline: Seahawks , Lions
For a moment, it looked like the Lions might be the class of the NFC North. But a very Lions-esque meltdown in the fourth quarter against the Vikings resulted in Detroit’s second loss of the season. One thing remains certain: the Lions can put points on the board (95 through three weeks.)
Geno Smith looks good enough to start in the NFL, but is he good enough to win games in the NFL? Following a shocking season-opening win over Denver, Seattle has lost two in a row. Smith threw for 325 yards and two scores against the Falcons in Week 3 but a late interception sealed the Seahawks’ fate.
Tennessee Titans at Indianapolis Colts
- Spread: Titans , Colts
- Moneyline: Titans , Colts
Before the season, these two teams were expected to battle for the AFC South crown. Finally, it’s starting to look that way again, although Jacksonville looks really good too.
Indy stunned the Chiefs as five-point home underdogs in Week 3. Several key players returned from injury after missing the Week 2 blowout loss to the Jaguars. Matt Ryan and the offense were mostly inept to the tune of 3.8 yards per play, but the defense held Patrick Mahomes to 257 yards through the air and picked him off late in the fourth quarter to seal the win.
The Titans finally found a way to get Derrick Henry (143 yards, 1 TD) more involved in the offense in Week 3 against the Raiders. Overall, it looked more like the Titans offense of old.
Indy opened as a 3.5-point favorite on the look-ahead line. Expect this to hover around the key number of three all week.
Chicago at New York Giants
- Spread: Bears , Giants
- Moneyline: Bears , Giants
The Giants are favored again, which you’d expect from an undefeated team, but underlying numbers tell a different story of how the Giants have looked to this point. New York failed to generate any consistent offense in a 23-16 loss the Cowboys on Monday Night Football, but oddsmakers didn’t see enough to move the line off Giants -3. In fact, it was trending toward Giants -3.5 as of Tuesday morning.
Jacksonville Jaguars at Philadelphia Eagles
- Spread: Jaguars , Eagles
- Moneyline: Jaguars , Eagles
Philadelphia continues to steamroll everything in its way. The Eagles look elite on both sides of the ball and, outside of a late comeback scare against Detroit, have coasted to three wins.
The Jaguars are looking feisty on defense with pass rushers Josh Allen and Travon Walker creating havoc. The entire Jags roster looked dominant in a 38-10 win over the Chargers.
The Eagles opened as seven-point favorites on the look-ahead.
Ny Jets Jets at Pittsburgh Steelers
- Spread: Jets , Steelers
- Moneyline: Jets , Steelers
There were no late-game miracles for New York in Week 3. The Jets had little answer for Joe Burrow and lacked the offensive firepower to play their way back into contention. Zach Wilson is expected to return for the Jets next week, but time will tell if this is an upgrade over Joe Flacco.
The Steelers get extra rest after losing 29-17 to Cleveland on Thursday Night Football. Mitch Trubisky is still taking snaps for now, but the Kenny Pickett chatter is escalating. The Steelers rank near the bottom of the NFL in yards per game and yards per play.
Buffalo Bills at Baltimore Ravens
- Spread: Bills , Ravens
- Moneyline: Bills , Ravens
The Bills are human after all. But what can be taken from Buffalo’s 21-19 loss in Miami? Not only was the defense without four key starters, but Buffalo outgained Miami 497 to 212. When it mattered in the red zone, Buffalo failed to convert.
The Bills get another tough challenge in Week 4 on the road against the 2-1 Ravens, although they are favored again. Baltimore took down New England in Week 3 despite being outgained. The injuries in the Ravens’ secondary remain a concern, especially with the Bills coming to town.
LA Chargers at Houston Texans
- Spread: Chargers , Texans
- Moneyline: Chargers , Texans
The Chargers decided to start Justin Herbert on Sunday against the Jaguars. He was mostly ineffective, completing only 25 of 45 passes with one TD and an INT. Keep an eye on Herbert’s injury status leading up to Sunday, but he should be healthy enough to go again. Los Angeles has multiple key injuries on both sides of the ball.
The Texans played another close game against the Bears but fell short. The Texans are 3-0 against the spread this season but have yet to find the win column. They’re unlikely to get a win here, even with the Chargers struggling.
Arizona Cardinals at Carolina Panthers
- Spread: Cardinals , Panthers
- Moneyline: Cardinals , Panthers
Both of these offenses looked uninspired in Week 3. Through three games, Baker Mayfield is barely completing 50% of his passes and has only three TDs. Kyler Murray threw the ball 58 times against the Rams in Week 3 but failed to punch the ball into the end zone in a 20-12 loss.
The Panthers defense led the way in a 22-14 home win against New Orleans. That performance helped move this off the look-ahead line of Cardinals -3.
New England Patriots at Green Bay Packers
- Spread: Patriots , Packers
- Moneyline: Patriots , Packers
Mac Jones left the Week 3 loss to the Ravens with an ankle injury. X-rays came back negative after the game, but he has a bad high-ankle sprain that could sideline him this week and beyond. Brian Hoyer would step in under center if Jones can’t go.
The Packers defense looked ferocious again in Week 3, holding Tom Brady and the Bucs to 12 points scored on 4.8 yards per play. This opened Packers -6 on the look-ahead line, but with Jones’ status in doubt, the spread should stay well above a touchdown.
Denver Broncos at Ls Vegas Raiders
- Spread: Broncos , Raiders
- Moneyline: Broncos , Raiders
Another divisional showdown on the Week 4 schedule, this time in the AFC West. Las Vegas fell to 0-3 in a disappointing loss to the Titans on Sunday. The talk in the offseason was about the bolstering of the Raiders’ offense, but that unit continues to struggle, notably quarterback Derek Carr.
Can Russell Wilson finally find some success against that Raiders defense? The Broncos won at home against the 49ers on Sunday Night Football, but Wilson threw for only 184 yards on 33 attempts. Denver is averaging just 14.3 points per game over the first three with Wilson under center.
Kansas City Chiefs at Tampa Bay Buccaneers
- Spread: Chiefs , Buccaneers
- Moneyline: Chiefs , Buccaneers
The last time these two teams played, the Bucs were hoisting the Lombardi trophy after a 31-9 shellacking over KC in Super Bowl LV.
Kansas City could be steaming after losing late to the Colts in Week 3 following costly special-teams miscues. Kansas City ran the ball 23 times for only 58 yards and the Colts did a solid job keeping Patrick Mahomes from gashing them on long plays through the air.
The Bucs present another stiff test for Mahomes. Tom Brady should get several weapons back in Week 4, including Mike Evans.
LA Rams at San Francisco 49ers
- Spread: Rams , 49ers
- Moneyline: Rams , 49ers
Football fans get a treat on Monday Night Football between two NFC West rivals. This is a rematch of last year’s NFC Championship Game where the Rams beat the 49ers 20-17 to advance to the Super Bowl.
The Rams are on the spread following a convincing road win over Arizona in Week 3. Expect this to hang around a PK at sportsbooks.