Another wild week of NFL games is behind us, and oddsmakers have already posted lines for Week 3. The slate is headlined by an Aaron Rodgers vs. Tom Brady showdown in Tampa Bay, and closes with the New York Giants hosting the Dallas Cowboys on Monday night.
In this article, you’ll find current odds posted by legal online sportsbooks in the US, along with key news and storylines to look for before placing a bet.
NFL Week 3 opening odds
Week 3 best odds and betting breakdown
Pittsburgh Steelers at Cleveland Browns
Spread: Steelers , Browns
Moneyline: Steelers , Browns
Week 3 kicks off with a division rivalry game in Cleveland. Both teams are coming off a loss. The Steelers struggled offensively (4.2 yards per play) in a 17-14 defeat to the Patriots, and the Browns handed a game away to the Jets after leading 30-17 with less than two minutes remaining.
Look for this to hang around the key number of three in favor of the Browns.
Kansas City Chiefs at Indianapolis Colts
Spread: Chiefs , Colts
Moneyline: Chiefs , Colts
This is a tilt between two teams heading in opposite directions. The 2-0 Chiefs get some extra time to prepare for this one after holding off the Chargers on Thursday night, while the Colts were shut out in Jacksonville as three-point favorites. The Chiefs were -3 on the look-ahead line for this game before the Week 2 results were determined.
Injuries will be worth watching for the Colts this week. Indy was without Michael Pittman and Alec Pierce in Week 2, and failed to demonstrate any consistency in the passing game. Matt Ryan went 16-of-30 with three INTs.
Baltimore Ravens at New England Patriots
Spread: Ravens , Patriots
Moneyline: Ravens , Patriots
The Ravens look to rebound from a shocking loss to Miami after leading by 21 in the fourth quarter. The offense appears to be firing on all cylinders, but the defense is dealing with several key injuries in the secondary. That was evident in Tua Tagovailoa’s 469-yard air assault in Week 2.
New England held on to beat a battered Pittsburgh team in Week 2. They will likely look to continue pounding the ball on the ground and controlling the tempo against this explosive Ravens offense.
Houston Texans at Chicago Bears
Spread: Texans , Bears
Moneyline: Texans , Bears
This might be the only game the Bears are favored in during the 2022-23 season. Oddsmakers posted this right on the key number (3) as Week 2 afternoon games were ending on Sunday, but some early money came in on the Texans to push it to Bears -2.5.
Despite coming into the season among the cellar-dwellers, the Texans have played two tight games against potential playoff teams. Even as a road underdog, this presents one of their best opportunities for a win this season.
Las Vegas Raiders at Tennessee Titans
Spread: Raiders , Titans
The Raiders played two different halves against Arizona in Week 2, ultimately losing in overtime to bring their record to 0-2. Penalties were a killer, but the Raiders offense also fell flat in the second half. Davante Adams was held to two catches for 12 yards.
Coming off an embarrassing loss in Buffalo, the Titans return home looking for their first win as a home underdog.
Buffalo Bills at Miami Dolphins
Spread: Bills , Dolphins
Moneyline: Bills , Dolphins
The last time Miami beat Buffalo, Josh Allen was making his first-ever start again the Dolphins four years ago. Since then, Allen is 7-0 against Miami.
Miami tallied 547 yards of offense in a 42-38 thriller against Baltimore to start the season 2-0, but oddsmakers still have Buffalo as a sizable favorite on the road in Week 3. In fact, the spread moved from 4.5 to 6 after the Bills walloped the Titans on Monday Night Football.
Detroit Lions at Minnesota Vikings
Moneyline: Lions , Vikings
The Lions boast one of the most explosive offensives through two weeks, scoring an NFC-leading 71 points. The spread for this game moved off the 7.5-point look-ahead after Detroit’s victory over Washington, and moved even further toward Detroit after the Vikings lost to the Eagles on Monday night. This game has the highest total point of the week, so look for the Vikings to rebound from a seven-point offensive effort in Week 2.
Cincinnati Bengals at New York Jets
Spread: Bengals , Jets
Moneyline: Bengals , Jets
Just when we thought the Bengals couldn’t look any worse than they did in the season opener against Pittsburgh, they went to Dallas and lost as seven-point favorites to a backup QB. Joe Burrow and the Bengals offense only accounted for 3.8 yards per play against the Cowboys.
The Jets, meanwhile, pulled off an unthinkable upset against the Browns behind an impressive air attack in the fourth quarter. They return home as an underdog this week, but the Bengals appear to be far more vulnerable than expected after reaching the Super Bowl last year.
Philadelphia Eagles at Washington Commanders
Spread: Eagles , Commanders
Moneyline: Eagles , Commanders
The Carson Wentz-led Commanders have put points on the board early in the season, but the defense is undeniably missing its all-world pass-rusher Chase Young. Washington has allowed 58 points through two weeks.
The Eagles opened as field-goal favorites on the look-ahead line, but that number grew to 6.5 after a convincing win over the Vikings on MNF.
New Orleans Saints at Carolina Panthers
Spread: Saints , Panthers
Moneyline: Saints , Panthers
Baker Mayfield and the Panthers lost another close game in Week 2. Can they turn it around against the division rival Saints?
Jameis Winston threw three picks in an ugly loss to Tampa Bay. The defense, however, looked tremendous against Tom Brady, holding the Buccaneers to 4 yards per play.
Jacksonville Jaguars at Los Angeles Chargers
Spread: Jaguars , Chargers
Moneyline: Jaguars , Chargers
Betting markets for this game hinge on the status of Justin Herbert, who battled through a rib injury at the end of the Week 2 loss to the Chiefs. His absence would have a massive impact on the betting lines, especially following an impressive performance by the Jaguars.
Even if Herbert does suit up, his level of comfort will be uncertain. That makes for a difficult handicap for NFL bettors.
Green Bay Packers at Tampa Bay Buccaneers
Spread: Packers , Bucs
Moneyline: Packers , Bucs
Easily the most anticipated game on the Week 3 slate, Tom Brady faces Aaron Rodgers for the fifth time in their careers. Brady leads the all-time series, 3-1, including a 38-10 victory for the Bucs in 2020.
Brady’s Bucs started this season 2-0 but there are serious concerns at receiver; Chris Godwin and Julio Jones missed the Week 2 game against New Orleans, and Mike Evans could be facing a suspension after being ejected in that game.
Rodgers has his own issues at receiver, but the offense was far more balanced in Week 2 with the return of Allen Lazard.
Los Angeles Rams at Arizona Cardinals
Spread: Rams , Cardinals
Moneyline: Rams , Cardinals
The Cardinals ride the energy of an improbable comeback win over Las Vegas into this home tilt against the defending champions. Los Angeles nearly blew a 28-3 lead at home to Atlanta but held on to move to 1-1.
Keep an eye on the health of Arizona’s receiving corps, including speedy Rondale Moore, who has missed both of Arizona’s first two games.
Atlanta Falcons at Seattle Seahawks
Spread: Falcons , Seahawks
Moneyline: Falcons , Seahawks
Similar to the Bears-Texans game above, a faceoff between two of the NFL’s worst teams results in the Seahawks being favored in a football game. The Hawks never stood a chance in Week 2 against a more physical 49ers team that bullied Seattle all over the field.
The Falcons nearly pulled off a miracle comeback against the defending champion LA Rams in Week 2. Even at 0-2 in the standings, Atlanta has showed a lot of promise on the offensive side of the ball.
San Francisco 49ers at Denver Broncos
Spread: 49ers , Broncos
Moneyline: 49ers , Broncos
Trey Lance is out for the year, but the Niners might be better off with Jimmy Garropolo under center in the short term. This does, however, leave San Francisco without any depth at QB. Oddsmakers will adjust accordingly.
The Broncos have moved the ball well offensively but continue to struggle in the red zone. If Russell Wilson and Co. can figure out how to punch it in, the Broncos could finally realize their potential.
Watch for Jerry Jeudy and Patrick Surtain injury news this week for Denver, as they both left Sunday’s game with injuries.
Dallas Cowboys at New York Giants
Spread: Cowboys , Giants
Moneyline: Cowboys , Giants
The Giants are 2-0 in the standings but didn’t look overly impressive in either win. They were outgained 5.1 to 3.8 yards per play by Carolina in Week 2 but won the turnover battle, 2-0.
Could the Cowboys be better without Dak Prescott under center? Likely not, but the defense was back to being disruptive against Joe Burrow in Week 2, leading to a shocking win with backup QB Cooper Rush.