Week 13 of NFL betting continues on primetime with a Sunday night matchup between the Bills and 49ers.
According to NFL betting data from bet365, these are the players most likely to find the end zone (odds subject to change before kickoff).
Anytime touchdown scorer odds
Christian McCaffrey, anytime touchdown scorer favorite
As is often the case when he plays, no one is deemed more likely to find the end zone than 49ers running back Christian McCaffrey.
At -138, the reigning offensive player of the year is the standalone favorite to score a touchdown on Sunday night. He is the only 49er priced inside the top seven.
McCaffrey has yet to find the end zone in his three games since returning from a knee injury that kept him out until Week 10. That is tied for his longest scoreless streak as a 49er. Should he fail to score Sunday, it would be the longest touchdown drought of his career since his first four games as a rookie back in 2017.
Last year, McCaffrey set an NFL record with touchdowns in 17 consecutive games. He has not closed below -165 to score a touchdown since Week 1 of last year, according to data from bet365.
James Cook
At -120, James Cook is the next most likely to find the end zone on Sunday, according to bet365.
Cook has scored the most touchdowns this season of any player in this game and is tied for the fourth most touchdowns in the league through Week 12. He has scored in seven of his last 10 prime-time games.
The 49ers have allowed the third-most rushing touchdowns of any team this year, making Cook a likely candidate to score on Sunday Night Football.
Josh Allen
San Francisco’s vulnerability to rushing scores has Josh Allen at +120, which is the third-shortest touchdown odds for this game.
Jalen Hurts is the only quarterback to have scored more rushing touchdowns this season than Allen, who has five. Allen has scored in each of his last two games.
According to data from Lineups, the 49ers have allowed the seventh most rushing touchdowns to opposing quarterbacks this season.
Amari Cooper, Khalil Shakir
At +162, Amari Cooper and Khalil Shakir are tied for the most likely wide receivers to score on Sunday night, according to bet365.
The 49ers have been stingier against wide receivers this year, ranking 22nd in receiving touchdowns given up to opponents.
Cooper hasn’t scored since Week 10, his first game as a Bill after coming over in a trade from the Browns. He is considered the team’s wide receiver, though Shakir outranks him in targets and catches.
Shakir has led Buffalo in total targets and has hauled in a team-best seven of eight targets inside the 20-yard line, including a touchdown in Week 3 against Jacksonville.
