Buffalo Bills Odds

The Buffalo Bills snapped a two-game skid with a victory over the Cleveland Browns on Sunday. It was an eventful week in Buffalo as a massive snowstorm blanketed the region, forcing the Bills to move what should have been a home game over to Ford Field in Detroit. Interestingly, the team is headed to the same stadium in Week 12 as it has a date with the Detroit Lions on Thanksgiving Day. The Bills enter at 7-3 and remain among the favorites in Super Bowl futures, while Detroit has won three straight to get to 4-6 on the year. Here’s a closer look at the latest Bills odds and betting lines.

Buffalo Bills odds: Spread, moneyline and over/under

Week 12 odds: Bills in Thanksgiving Day spotlight versus Lions

The Bills were eight-point favorites for the date with the Browns. After falling behind 10-3 and looking slightly out of sorts while doing so, the club took control the rest of the way and cruised to a 31-23 victory. The Lions were at the New York Giants as three-point underdogs on Sunday. They certainly didn’t play that way as they rolled to a 31-18 win.

Buffalo is 5-4-1 against the spread and has been trending under at 3-7 on totals. Detroit is 6-4 ATS and leaning in the opposite direction at 7-3 on the over/under. The two teams last met in 2018, a 14-13 home win for the Bills, who also hold a 6-4-1 lead in the all-time series.  

Bills vs. Lions player props

Down below, you can enter the name of your player of choice to find the best available player prop odds. If you see a bet that you like, click on it to redirect to the sportsbook to place your wager.

The Bills are averaging 28.1 points per game and allowing 17.4. Josh Allen is a top four favorite in MVP futures, throwing for 21 TDs and 10 picks to date. Stefon Diggs has 76 receptions for 1,033 yards and eight scores. The Lions are scoring an average of 25.0 while giving up 28.2. Jared Goff has tossed for 15 scores and seven INTs. Jamaal Williams has emerged as a TD machine with 12 trips to the end zone thus far. Here’s a look at a few Bills vs. Lions player props and the latest odds.

Buffalo Bills odds to win the 2023 Super Bowl

Last updated: Nov. 23

When DraftKings released its lines in January, the Buffalo Bills were in second place with odds at +800, behind only the Chiefs. After the team’s 7-3 start to the season, the odds for the Bills stand at . Buffalo has been to the postseason for the last three seasons, but the team has only advanced to the AFC title game once over that span, losing to the Chiefs in 2020.

Buffalo Bills futures odds for 2022-23

We can expect the Bills to continue receiving plenty of attention as Super Bowl contenders, but that’s far from the only way to wager on what’s to come this season. Here’s a look at the futures odds for Buffalo in some other key categories:

Assuming that the Bills offense continues firing on all cylinders, Allen and Diggs are legitimate contenders for yardage titles. Across the board in the team categories, Buffalo is a clear favorite and a viable threat to win.

How to bet on the Buffalo Bills

The main pregame betting odds for NFL games revolve around three wagers: moneyline, spread and over/under. Here’s how they work:


The moneyline bet is straightforward: just pick which side you think will win the game. On a main game listing, there will be odds listed for both choices.

The direction of the odds gives you a quick understanding of the expectations for the game: negative numbers for favorites and positive for underdogs. The game is expected to be close when the moneyline odds are in a tight range.

For larger spans, the contest projects to be a mismatch, while plenty of other games will fall between the two extremes. At odds of -115, you’d have to bet $115 for a chance to win $100. If you bet $100 at odds of +105, the profit potential is $105.


Sportsbooks install a point spread for each NFL game. It’s meant to level the playing field between the two sides and can be thought of as an estimated margin of victory. Bettors can choose the favorite minus the points or the underdog plus the number.

For spread bets, there are two numbers to account for: the number set by oddsmakers and the actual odds on the bet. In the above example, the Rams are a 1-point favorite over the Bills, while the odds are set at -110 on both sides.

The odds for NFL point spreads tend to stay in a tight range around that number, which is part of the appeal for bettors. At odds of -110, a winning $100 bet will bring back $90.91, while you’d have to risk $110 for the chance to win $100.

Point total (over/under)

The point total lets you focus on how much scoring there will be in the game. Which side wins or loses is irrelevant. Your sole goal for this bet is to choose over or under on the total number of points listed by the sportsbook.

In this example, the bar is set at 52 points. If you bet on the over, you expect 53 or more points to be scored. Bettors on the opposite side anticipate that there will be 51 or less points scored. The bet pushes if the exact points scored match the total.

Like spreads, over/under bets tend to be set at -110 and remain in that range. However, you will find some variances while line shopping, such as one side dropping to -105 while the other increases to -115.

Buffalo Bills schedule

Week DateOpponentKickoff TimeSpreadMoneylineTotal
1Sept. 8at Los Angeles Rams8:20 p.m. ETBUF -2
Bills 31-10
Under 52.0
2Sept. 19vs. Tennessee Titans7:15 p.m. ETBUF -10
Bills 41-7
Over 47.0
3Sept. 25at Miami Dolphins1 p.m. ETMIA +4
Dolphins 21-19
Under 54.5
4Oct. 2at Baltimore Ravens1 p.m. ETPush -3
Bills 23-20
Under 50.5
5Oct. 9vs. Pittsburgh Steelers1 p.m. ETBUF -14
Bills 38-3
Under 44.5
6Oct. 16at Kansas City Chiefs4:25 p.m. ETBUF +2.5
Bills 24-20
Under 54.0
8Oct. 30vs. Green Bay Packers8:20 p.m. ETGB +10.5
Bills 27-17
Under 47.0
9Nov. 6at New York Jets1 p.m. ETNYJ +10.5
Jets 20-17
Under 46.0
10Nov. 13vs. Minnesota Vikings1 p.m. ETMIN +6.5
Vikings 33-30
Over 46.5
11Nov. 20vs. Cleveland Browns1 p.m. ETBUF -8
Bills 31-23
Over 50.0
12Nov. 24at Detroit Lions12:30 p.m. ETBUF -9 (-110)
DET +9 (-110)
Bills (-410)
Lions (+330)
54.0 (-110)
13Dec. 1at New England Patriots8:15 p.m. ET
14Dec. 11vs. New York Jets1 p.m. ET
15Dec. 18vs. Miami DolphinsTBD
16Dec. 24at Chicago Bears1 p.m. ET
17Jan. 2at Cincinnati Bengals8:30 p.m. ET
18Jan. 8vs. New England PatriotsTBD

Buffalo Bills news and notes

In advance of the season, oddsmakers viewed the Bills as a top contender to win it all, while the same applied to Josh Allen in the MVP chase. Through 10 games, the team is 7-3. The Bills are still Super Bowl favorites, and Allen is among the top four award favorites. However, the club has hit a rough patch while going 1-2 over the last three, winning over the Browns last time out. The game was moved to Detroit in the wake of a huge snowstorm that blanketed the Buffalo region. The Bills are back in Detroit this week for a Thanksgiving Day date with the Lions.

Other teams in the AFC

AFC EastBuffalo BillsMiami DolphinsNew England PatriotsNY Jets
AFC NorthBaltimore RavensCincinnati BengalsCleveland BrownsPittsburgh Steelers
AFC SouthHouston TexansIndianapolis ColtsJacksonville JaguarsTennessee Titans
AFC WestDenver BroncosKansas City ChiefsLA ChargersLas Vegas Raiders

Buffalo Bills FAQ

Are the Bills a Super Bowl contender?  

Yes, the Bills are the current favorites to win Super Bowl 57. The team has been to the playoffs for three straight seasons and is loaded with talent.

How did the Bills do against the spread last year?  

The Bills were 9-6-2 against the spread during the regular season and 1-1 ATS in the postseason. The team was 12-7 on the moneyline and 10-9 on the over/under.

Whom did the Bills add and lose in the offseason?  

The Bills signed star pass rusher Von Miller in free agency and added Kair Elam and James Cook as their top two picks in the NFL draft. Notable departures include Star Lotulelei and Cole Beasley.

How many years are left on Josh Allen’s contract?

Josh Allen signed a six-year contract extension with the Bills in August 2021. The total value is over $258 million. Allen was a first-round pick in the 2018 NFL draft, and the extension will keep him in Buffalo at least through the 2028 season.

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