Buffalo Bills Odds

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Buffalo Bills fans shouldn’t make parade plans just yet, but the club is looking like a serious contender this season. This club is loaded on both sides of the ball, and is the current betting favorite in Super Bowl futures odds as a result. Last season, the team’s quest for the crown came to an end with an overtime playoff loss to the Kansas City Chiefs.

The window is open for Buffalo to take a big leap forward this year. The Bills open on the road against last year’s champs, the Los Angeles Rams, in the season-opener on Thursday, Sept. 8 for what should be a stellar game. Here’s a closer look at the latest Bills betting odds and information.

Buffalo Bills odds: Spread, moneyline and over/under

Week 1 odds: Bills slight underdogs in visit to defending champ Rams

The NFL regular season kicks off with a potential Super Bowl preview. The Bills are the current favorites in the futures market to win it all, while the defending champion Rams are among the top five choices on the board.

A 1-point spread suggests that oddsmakers are viewing the game as close to a toss-up. It’s not hard to see why, as these are two of the most talented teams in the league even if it’s only Week 1 of the NFL season.

  • Moneyline: The odds are also pointing to a coin flip, with both teams even at -110 on the moneyline at several sportsbooks. Buffalo was 5-3 on the road a season ago, while Los Angeles held the same mark at home.
  • Spread: The Bills opened as tight one-point underdogs (+1) against the Rams in Week 1. For this meeting of two of the league’s best, the spread should remain fairly close until kickoff.
  • Over/Under: Just four of the Week 1 games have a total at 50 or more points. This matchup opened with an over/under of 52. There could be plenty of scoring in the forecast in Los Angeles as both squads were in the top eight for points per game last year: 28.4 for the Bills and 27.1 for the Rams.

Buffalo Bills odds to win the Super Bowl

Last updated: June 30

When DraftKings betting app released its lines in January, the Buffalo Bills were in second place to win the Super Bowl with odds at +800, behind only the Chiefs. As the offseason has progressed, the team has climbed to the top of the charts at +600.

The Bills are the favorites to win the AFC this season and ultimately Super Bowl 57. The team’s postseason streak now stands at three seasons, but Buffalo has only advanced to the AFC title game once over that span, losing to the Chiefs in 2020.

Buffalo Bills futures odds for 2022-23

We can expect the Bills to continue receiving plenty of attention as Super Bowl contenders, but that’s far from the only way to wager on what’s to come this season. Here’s a look at the futures market odds for Buffalo in some other key categories.

Regular season win total

DraftKings Sportsbook: Over 11.5 (-140)Under 11.5 (+120)

After an 11-win regular season, another year of double-digit wins and contention for the crown are the expectations in Buffalo. Just one other team, the Tampa Bay Buccaneers, has a win total as high as the Bills.         

Odds to win the AFC East

BetMGM Sportsbook: -190

The Bills are the favorites to win the AFC East by a wide margin. The Miami Dolphins and New England Patriots are next in the pecking order at +400 each. The Jets are the likely cellar dwellers at +1800.

Odds to win the AFC

Caesars Sportsbook: +360

To get to the big game, the Bills first have to win the AFC. Buffalo is the current top choice to represent that side of the bracket. The Chiefs are second at +500, followed by the Denver Broncos and Los Angeles Chargers at +850.

Josh Allen NFL MVP odds

FanDuel Sportsbook: +700

The Bills are favored across the board in futures markets, so it should come as no surprise that oddsmakers are expecting a big year from Allen. He’s the current favorite to win the NFL MVP at FanDuel.

 Season-long player prop odds

DraftKings Sportsbook

  • Most passing yards: Josh Allen +1000
  • Most rushing yards: Devin Singletary +3500
  • Most receiving yards: Stefon Diggs +1400

Assuming that the Bills’ offense continues firing on all cylinders, Allen and Diggs are legitimate contenders for yardage titles. While Singletary is a key cog in the offense, it’s unlikely that he’ll rack up tons of yardage.

How to bet on the Buffalo Bills

For NFL games, the main pregame betting odds revolve around three wagers: moneyline, spread, and over/under. Here’s how they work:


The moneyline bet is straightforward: just pick which side you think will win the game. On a main game listing, there will be odds listed for both choices.

  • Bills +105
  • Rams -115

The direction of the odds gives you a quick understanding of the expectations for the game: negative numbers for favorites and positive for underdogs. When the moneyline odds are in a tight range, the game is expected to be close.

For larger spans, the contest projects to be a mismatch, while plenty of other games will fall between the two extremes. At odds of -115, you’d have to bet $115 for a chance to win $100. If you bet $100 at odds of +105, the profit potential is $105.


Sportsbooks install a point spread for each NFL game. It’s meant to level the playing field between the two sides and can be thought of as an estimated margin of victory. Bettors can choose the favorite minus the points or the underdog plus the number.

  • Bills +1 (-110)
  • Rams -1 (-110)

For spread bets, there are two numbers to account for: the number set by oddsmakers and the actual odds on the bet. In the above example, the Rams are a 1-point favorite over the Bills, while the odds are set at -110 on both sides.

The odds for NFL point spreads tend to stay in a tight range around that number, which is part of the appeal for bettors. At odds of -110, a winning $100 bet will bring back $90.91, while you’d have to risk $110 for the chance to win $100.

Point total (over/under)

The point total lets you focus on how much scoring there will be in the game. Which side wins or loses is irrelevant. Your sole goal for this bet is to choose over or under on the total number of points that are listed by the sportsbook.

  • Over 52 (-110)
  • Under 52 (-110)

In this example, the bar is set at 52 points. If you bet on the over, that means that you’re executing 53 or more points to be scored. Bettors on the opposite side are anticipating that there will be 51 or less points scored. The bet pushes if the exact points scored match the total.

Similar to spreads, over/under bets tend to be set at -110 and remain in that range. However, you will find some variances while line shopping, such as one side dropping to -105 while the other increases to -115.

Buffalo Bills schedule

Week DateOpponentKickoff TimeSpreadMoneylineTotal
1Sept. 8at Los Angeles Rams8:20 p.m. ETLAR -1Rams (-110), Bills (-110)52 pts
2Sept. 19vs. Tennessee Titans7:15 p.m. ET
3Sept. 25at Miami Dolphins1 p.m. ET
4Oct. 2at Baltimore Ravens1 p.m. ET
5Oct. 9vs. Pittsburgh Steelers1 p.m. ET
6Oct. 16at Kansas City Chiefs4:25 p.m. ET
8Oct. 30vs. Green Bay Packers8:20 p.m. ET
9Nov. 6at New York Jets1 p.m. ET
10Nov. 13vs. Minnesota Vikings1 p.m. ET
11Nov. 20vs. Cleveland Browns1 p.m. ET
12Nov. 24at Detroit Lions12:30 p.m. ET
13Dec. 1at New England Patriots8:15 p.m. ET
14Dec. 11vs. New York Jets1 p.m. ET
15Dec. 17 OR Dec. 18vs. Miami DolphinsTBD
16Dec. 24at Chicago Bears1 p.m. ET
17Jan. 2at Cincinnati Bengals8:30 p.m. ET
18Jan. 7 OR Jan. 8vs. New England PatriotsTBD

Buffalo Bills news and notes

The Bills were active in free agency and added some key pieces on both sides of the ball. On defense, the biggest acquisition was the signing of Von Miller. The pass rusher could be a difference-maker for a unit that was already solid. For the offense, Josh Allen has a new weapon to consider, as the team signed wideout Jamison Crowder. The Bills also re-signed WR Isaiah McKenzie.

At the draft, the Bills used the 23rd overall selection on CB Kair Elam. The team’s round two selection, RB James Cook, is yet another piece for the offense, while third-round LB Terrel Bernard could provide some depth. Add it all up, and one of the league’s most talented teams appears to have improved itself over a busy offseason.

Buffalo Bills FAQ

Are the Bills a Super Bowl contender?  

Yes, the Bills are the current favorites to win Super Bowl 57. The team has been to the playoffs for three straight seasons and is loaded with talent.

How did the Bills do against the spread last year?  

The Bills were 9-6-2 against the spread during the regular season and 1-1 ATS in the postseason. The team was 12-7 on the moneyline and 10-9 on the over/under.

Whom did the Bills add and lose in the offseason?  

The Bills signed star pass rusher Von Miller in free agency and added Kair Elam and James Cook as their top two picks in the NFL draft. Notable departures include Star Lotulelei and Cole Beasley.

How many years are left on Josh Allen’s contract?

Josh Allen signed a six-year contract extension with the Bills in August 2021. The total value is over $258 million. Allen was a first-round pick in the 2018 NFL draft, and the extension will keep him in Buffalo at least through the 2028 season.

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