The Buffalo Bills’ Week 2 odds have the team at +2 in a road game against the Miami Dolphins on Thursday Night Football. Buffalo is coming off a home win over the Cardinals to open its season and heads into this AFC East matchup at +110 on the moneyline. The Bills’ 2025 Super Bowl odds improved slightly this week to +1600.
Buffalo Bills Week 2 odds
Below, you can find the latest NFL lines for upcoming Bills games as they become available at online sportsbooks.
Bills Week 2 player props
Bills player props are available for the team’s Week 2 matchup with the Dolphins. NFL sportsbooks will list props for key players all season long. Clicking on a bet that you’d like to place will take you right to the sportsbook offering that wager.
Buffalo Bills odds to win the Super Bowl
Last updated: September 2024
When Super Bowl 59 odds came out at NFL betting sites in January, the Bills’ line was +900. The Bills’ current odds to win the 2025 Super Bowl are .
Buffalo Bills win total odds
Buffalo Bills futures odds for 2024
Here’s a look at the latest Bills futures odds for the upcoming season.
| Bills futures | Current odds |
| To win the AFC | |
| To win the AFC East | |
| Top two in AFC East | |
| To have the best regular season record | |
| To make the playoffs | |
| To go 17-0 |
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Bills 2024 schedule
| Away team | Home team | Date & time | Location |
|---|---|---|---|
| Cardinals (+7) | Bills (-7) | 9/8, 1 p.m. ET | Highmark Stadium |
| Bills (+1.5) | Dolphins (-1.5) | 9/12, 8:15 p.m. ET | Hard Rock Stadium |
| Jaguars (+4.5) | Bills (-4.5) | 9/23, 7:30 p.m. ET | Highmark Stadium |
| Bills (+3) | Ravens (-3) | 9/29, 8:20 p.m. ET | M&T Bank Stadium |
| Bills (+1.5) | Texans (-1.5) | 10/6, 1 p.m. ET | NRG Stadium |
| Bills (+1) | Jets (-1) | 10/14, 8:15 p.m. ET | MetLife Stadium |
| Titans (+7) | Bills (-7) | 10/20, 1 p.m. ET | Highmark Stadium |
| Bills (-2) | Seahawks (+2) | 10/27, 4:05 p.m. ET | Lumen Field |
| Dolphins (+3) | Bills (-3) | 11/3, 1 p.m. ET | Highmark Stadium |
| Bills (-2) | Colts (+2) | 11/10, 1 p.m. ET | Lucas Oil Stadium |
| Chiefs (-1) | Bills (+1) | 11/17, 4:25 p.m. ET | Highmark Stadium |
| 49ers (-2) | Bills (+2) | 12/1, 8:20 p.m. ET | Highmark Stadium |
| Bills (-1) | Rams (+1) | 12/8, 4:25 p.m. ET | SoFi Stadium |
| Bills (+2) | Lions (-2) | 12/15, 4:25 p.m. ET | Ford Field |
| Patriots (+7.5) | Bills (-7.5) | 12/22, 1 p.m. ET | Highmark Stadium |
| Jets (+2.5) | Bills (-2.5) | 12/29, 1 p.m. ET | Highmark Stadium |
| Bills (-3.5) | Patriots (+3.5) | 1/5, TBD | Gillette Stadium |
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Buffalo Bills FAQ
The Bills are among the AFC favorites to win the 2025 Super Bowl. At the initial release of Super Bowl 59 futures odds, the club was the third team on the board, behind only the 49ers and Chiefs.
The Bills were 8-11 against the spread last season, including the postseason. The team went 12-7 on the moneyline and 8-11 on the over/under.
The Bills signed Curtis Samuel during free agency. Stefon Diggs is among the players who have moved on from Buffalo. The team’s first pick at the NFL Draft was WR Keon Coleman.
Josh Allen signed a six-year contract extension with the Bills in August 2021. The total value is over $258 million. Allen was a first-round pick in the 2018 NFL Draft, and the extension will keep him in Buffalo at least through the 2028 season.