San Francisco 49ers Odds

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The San Francisco 49ers have made it to the NFL’s final four in two of the last three seasons, but changes are still coming as the team gets ready for the preseason opener versus the Green Bay Packers. Trey Lance is taking over at QB, but Jimmy Garropolo is still in town.

As training camp continues, the 49ers are one of the top eight choices in the latest Super Bowl odds. The club opens the season on the road and is currently a sizable favorite over the Chicago Bears. Here’s a closer look at the latest 49ers betting odds and angles.

San Francisco 49ers odds: Spread, moneyline and over/under

NFL Preseason Week 1: 49ers home for visit from Packers

The 49ers begin the preseason with a home matchup against the Green Bay Packers, a team they got the better of in last year’s playoffs. The action gets underway on Friday, Aug. 12 with kickoff set for 8:30 p.m. ET.

It’s tough to know what to expect in the opening week of the preseason, but betting lines are available. San Francisco is favored to get the win at home, but scoring could be on the light side.

  • Moneyline: The opening lines had the 49ers as a -155 favorite, but betting action has shifted the numbers to San Francisco -140 and Green Bay +120.
  • Spread: San Francisco was initially installed as a field goal (-3, -110) favorite for the preseason opener, but the spread has since dipped to 49ers -2.5 (-110).
  • Over/Under: The total of 33 points suggests that the offenses won’t be firing on all cylinders.

Week 1 49ers odds: San Francisco big favorite for Chicago road trip

The 49ers closed out last season with a record of 10-7, which was good enough to secure a wild-card berth. The team advanced to the NFC title game before falling to the Rams. It was a long season for a Bears team that went 6-11, and a head coaching change followed.

Futures odds paint a very different picture for both clubs. Sportsbooks expect the 49ers to contend in the NFC once again, while the rebuild continues for the Bears.

  • Moneyline: San Francisco is a -255 moneyline favorite against Chicago (+215) in Week 1 NFL lines. The 49ers were a solid road team last season with a mark of 6-3. The Bears struggled at home with a record of 3-5. The two clubs hooked up in Chicago in Week 8 last season, and San Francisco exited with a 33-22 victory.
  • Spread: San Francisco is a 6.5-point road favorite for the Week 1 opener. The 49ers were 12-8 against the spread last year. The Bears went 6-11.
  • Over/Under: Of the 16 listed totals for Week 1 of the NFL season, this is one of lowest numbers on the board at 42. The 49ers averaged 25.1 points per game last season, while the Bears checked in with an average of 18.3.

San Francisco 49ers odds to win the Super Bowl

Last Updated: August 11

When DraftKings first released odds on the winner of the next Super Bowl in January, the 49ers were toward the top of the board at +1400. The team’s odds have since moved slightly to +1600, but they remain one of the top eight favorites.

At DraftKings, the 49ers are the fourth option among NFC teams behind the Tampa Bay Buccaneers (+700), Green Bay Packers (+1000), and Los Angeles Rams (+1100). The Buffalo Bills (+600) are currently the top choice to win the 2023 Super Bowl.

Here are the odds on San Francisco to win Super Bowl 57 at other top online sportsbooks:

San Francisco 49ers futures odds for 2022-23

As the Super Bowl futures odds indicate, the 49ers are receiving attention as a potential contender. Beyond wagering on the team to break through and win the big game, you can also place your bets on the club in other areas. Here are some of the latest futures odds for San Francisco.

Regular season win total

DraftKings Sportsbook: Over 10 (+100) / Under 10 (-120)

The 49ers were a 10-win team last season. The oddsmakers at DraftKings have kept the bar in the same place. Based on the current odds, more betting action has been coming in on the team to go under that number.                       

Odds to win the NFC West

BetMGM Sportsbook: +200

The latest odds at BetMGM have the 49ers slotted in second place in the division. The Rams (+120) are the current favorites, with the Arizona Cardinals (+300) projected for third and the Seattle Seahawks (+1600) in fourth.

Odds to win the NFC

Caesars Sportsbook: +750

The 49ers are the fourth choice on the odds board at Caesars. The Buccaneers (+340) are the current favorites to win the conference, followed by the Rams (+450) and Packers (+450).

Trey Lance NFL MVP odds

FanDuel Sportsbook: +4000

There’s an air of uncertainty about what the 49ers offense will look like with Lance at the helm. He’s currently tied for 14th on the odds board at FanDuel. Josh Allen (+700) tops the odds board, then Patrick Mahomes (+800) and Tom Brady (+800).

Season-long player prop odds

DraftKings Sportsbook:

  • Most passing yards: Trey Lance +5000
  • Most rushing yards: Elijah Mitchell +3000
  • Most receiving yards: Deebo Samuel +2500

Mitchell and Samuel are top 10 contenders in their respective categories, while Lance is well down the list for passing yards. Now that Lance is poised to take the reins for the offense, it’s challenging to forecast what to expect in San Francisco.

San Francisco 49ers schedule

Week DateOpponentKickoff TimeSpreadMoneylineTotal
1Sept. 11at Chicago Bears1 p.m. ETSF -6.549ers (-265), Bears (+225)42.5 pts
2Sept. 18vs. Seattle Seahawks4:05 p.m. ET
3Sept. 25at Denver Broncos8:20 p.m. ET
4Oct. 3vs. Los Angeles Rams8:15 p.m. ET
5Oct. 9at Carolina Panthers4:05 p.m. ET
6Oct. 16at Atlanta Falcons1 p.m. ET
7Oct. 23vs. Kansas City Chiefs4:25 p.m. ET
8Oct. 30at Los Angeles Chargers4:25 p.m. ET
10Nov. 13vs. Los Angeles Chargers8:20 p.m. ET
11Nov. 21vs. Arizona Cardinals (in Mexico City)8:15 p.m. ET
12Nov. 27vs. New Orleans Saints4:25 p.m. ET
13Dec. 4vs. Miami Dolphins4:05 p.m. ET
14Dec. 11vs. Tampa Bay Buccaneers4:25 p.m. ET
15Dec. 15at Seattle Seahawks8:15 p.m. ET
16Dec. 25vs. Washington Commanders4:05 p.m. ET
17Jan. 1at Las Vegas Raiders4:05 p.m. ET
18Jan. 7 OR Jan. 8vs. Arizona CardinalsTBD

Latest news and updates

Entering the offseason, the 49ers appeared likely to move Jimmy Garoppolo, but the QB remains on the roster as we head toward training camp. During free agency, the headline signing was Charvarius Ward, while players who have moved on from San Francisco included Laken Tomlinson and D.J. Jones.

At the NFL draft, the 49ers were on the sidelines until round two when they selected DE Drake Jackson. The team had a pair of picks in the following round, landing RB Tyrion Davis-Price and WR Danny Gray. On paper, the 49ers still shape up as a contender, but questions abound on what the offense will look like with Lance behind center.

Other teams in the NFC

NFC EastDallas CowboysNY GiantsPhiladelphia EaglesWashington Commanders
NFC NorthChicago BearsDetroit LionsMinnesota VikingsGreen Bay Packers
NFC SouthAtlanta FalconsCarolina PanthersNew Orleans SaintsTampa Bay Bucs
NFC WestArizona CardinalsLA RamsSan Francisco 49ersSeattle Seahawks

San Francisco 49ers FAQ

Are the 49ers a Super Bowl contender this season?

Yes. The 49ers are one of the top eight favorites to win the Super Bowl, according to the latest odds from DraftKings. The team is the fourth choice among NFC squads, behind the Buccaneers, Packers, and Rams.

How did the 49ers do against the spread last year?

The 49ers were 12-8 against the spread last season, which was one of the five best records in the league on that metric. The team went 12-8 on the moneyline and 8-12 on totals.

Whom did the 49ers add and lose in the offseason?

The main signing was Charvarius Ward in free agency, while Laken Tomlinson and D.J. Jones were among those moving on. The team’s first pick in the NFL draft was Drake Jackson in round two.

Who is the 49ers starting QB this year?

Trey Lance is set to be the starting QB for the 49ers this season. The team’s first-round draft pick in 2021, he appeared in six games as a rookie. Jimmy Garoppolo remains on the team, but he may be moved before the start of the season.

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