2022 NFL Week 6 Odds: Spreads, Totals, Props For Every Game

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It’s still early in the NFL season, but a few contenders are beginning to separate themselves from the pack. Other squads appear destined to battle for lofty picks in the NFL Draft, while the rest of the clubs are between the two extremes and jockeying for position.

We should get more clarity this week as a few marquee games will provide us with additional insight into the Super Bowl quest. Among the top highlights is a playoff rematch and a meeting of two potential title teams when the Bills square off with the Chiefs.

In this article, we have the latest NFL betting odds for all of the remaining games, plus matchup previews, player props, the latest news, and more. Read on for a complete look at NFL Week 6 and what you need to know about betting on this week’s games.

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NFL Week 6 matchups and best odds

There are 13 games remaining on the Week 6 slate. Here’s what you need to know about each matchup and the latest odds for pregame bets.

San Francisco 49ers at Atlanta Falcons

The 49ers dominated the Panthers last week to get to 3-2 on the year. They remain among the favorites to win the NFC and boast one of the league’s best defenses, though they sustained key injuries last week. This week, it’s off to Atlanta to square off with the Falcons, a team that has been competitive through five weeks of play and stands at 2-3.

New England Patriots at Cleveland Browns

The banged-up Patriots silenced some critics with a shutout victory over the Lions last time out. Mac Jones has been out with an ankle injury, and Damien Harris is now expected to miss several games with a hamstring injury. The Browns enter at 2-3 and are looking to snap a two-game skid. Nick Chubb tops the league in rushing yards through five games.

New York Jets at Green Bay Packers

The Jets are fresh off a resounding win over the shorthanded Dolphins in which they dropped 40 points. Breece Hall was among the standouts in the victory as he racked up 197 total yards and a score. Meanwhile, the Packers are looking to bounce back from an upset loss to the Giants over in London. The slow start for Aaron Rodgers and company continues.

Jacksonville Jaguars at Indianapolis Colts

After five games, the Jaguars are a tough team to figure out. Since blowing out the undermanned Chargers on the road, the club has dropped two straight, including last week’s 13-6 decision to the Texans. The Colts are also resembling a team that still hasn’t found its way. Matt Ryan and the offense have yet to click for the 2-2-1 club.

Minnesota Vikings at Miami Dolphins

At 4-1, the Vikings are in first place in the NFC North. The club is riding a three-game winning streak and continues to garner attention as a club that could make some noise in the postseason. The Dolphins were generating buzz at 3-0, but two straight losses and injuries at QB have killed the momentum. Rookie Skylar Thompson gets the start this week.

Cincinnati Bengals at New Orleans Saints

The Bengals lost a close one to the Ravens on Sunday night to fall a step back in the NFC North chase. Now 2-3, last year’s AFC champs head to New Orleans looking for some answers. The Saints have been without Jameis Winston, but the tag team duo of Andy Dalton and Taysom Hill did just fine in last week’s 39-32 win over the Seahawks.

Baltimore Ravens at New York Giants

The Ravens are tops in the AFC North with a record of 3-2. They boast a legitimate MVP candidate in Lamar Jackson, but concerns remain about a defense that couldn’t hold a pair of late leads in the two defeats. They’ll take on a 4-1 Giants team that is exceeding expectations thus far. Saquon Barkley is currently second in the league in rushing yards.

Tampa Bay Buccaneers at Pittsburgh Steelers

The Buccaneers haven’t lived up to expectations just yet. Tampa Bay snapped a two-game skid with a closer-than-expected win over the Falcons, but concerns on offense are still lingering. The Steelers are looking to recover from a beatdown at the hands of the Bills. It’ll be Kenny Pickett under center once again for a team that needs to right the ship.

Carolina Panthers at Los Angeles Rams

After last week’s lopsided loss to the 49ers, the Panthers parted ways with coach Matt Rhule and replaced him with Steve Wilks on an interim basis. PJ Walker gets the start this week as Baker Mayfield is dealing with a high ankle sprain. Carolina is a big underdog to the defending champion Rams, a 2-3 club that continues to work through a big-game hangover.

Arizona Cardinals at Seattle Seahawks

It’s a meeting of a pair of 2-3 NFC West teams that are looking to bounce back from losses. The Cardinals have yet to develop any consistency, but they did give the undefeated Eagles a tough time last week. The Seahawks are producing great output on offense with Geno Smith at the helm. Unfortunately, the defense is also giving up points in buckets.

Buffalo Bills at Kansas City Chiefs

The Chiefs outlasted the Bills in overtime in last year’s playoff matchup, so revenge will certainly be on the mind of the visitors. Josh Allen and Patrick Mahomes are leading MVP candidates, while the two clubs top the charts in Super Bowl odds. It’s not only the best matchup of the week on paper, but also a potential game of the year candidate.

Dallas Cowboys at Philadelphia Eagles

The Cowboys have won four straight since losing Dak Prescott to injury. Cooper Rush has filled in admirably, while the defense has been much better than advertised. The Eagles remain undefeated and on top of the NFC East. This early season battle between two division heavyweights could have some major ramifications on the race.

Denver Broncos at Los Angeles Chargers

The week closes out with a meeting of two clubs that entered the season with huge expectations on their shoulders. After five weeks, neither the 2-3 Broncos nor the 3-2 Chargers have lived up to them. They’re both behind the Chiefs in the AFC West chase. The loser of this tilt will find themselves with that much more ground to make up.

More NFL weekly odds content

Find more odds for every NFL week as well as detailed analysis and breakdowns.