2023 NFL Week 4 Odds: Spreads, Totals, Props For Every Game

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Week 4 of the 2023 NFL season kicks off with an NFC North battle between the Detroit Lions and Green Bay Packers on Thursday, Sept. 28. This intriguing matchup features the preseason division favorite Lions looking to hold off the new-look Packers.

Other spotlight games on the following Sunday include the New England Patriots playing the Dallas Cowboys, and then the Kansas City Chiefs traveling to New Jersey to take on the New York Jets. This is also the first week where an early international game will take place.

NFL Week 4 updated odds and lines

Here are the most current lines for NFL week 4. We have totals, spreads, and moneylines.

NFL Week 4 spread odds

NFL Week 4 moneyline odds

NFL Week 4 over/under odds

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All the best sports betting sites we recommend feature Week 4 NFL odds. The betting market features typical game lines and various props for teams and players. New customers can check out the available welcome promos if they sign up to place a bet at any of the books below.

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NFL Week 4 matchups and best odds

The international series begins with the Atlanta Falcons taking on the Jacksonville Jaguars at Wembley Stadium in London. Nine games on Sunday will begin at 1 p.m. ET, and then three more games will follow in the late afternoon.

Detroit Lions at Green Bay Packers

Thursday Night Football, 8:15 p.m. ET, Prime Video

The Detroit Lions entered the season as the favorites to win the NFC North, something the franchise last accomplished in 1993 when the division was called the NFC Central. The Lions head to Green Bay after playing two home games against the Seahawks and Falcons. 

The Green Bay Packers are turning to Jordan Love as their next franchise quarterback. His weapons have been injured early in the season with receivers Christian Watson, Romeo Doubs, and tailback Aaron Jones all dealing with hamstring issues. The Packers host the Saints Sunday afternoon in Week 3. 

Atlanta Falcons vs. Jacksonville Jaguars

Sunday, 9:30 a.m. ET, ESPN+

The Atlanta Falcons head to London after a Week 3 matchup at Detroit. The Falcons are a run-heavy team that is featuring rookie Bijan Robinson and second-year back Tyler Allgeier behind a strong offensive line. Atlanta boosted its secondary this offseason by signing safety Jessie Bates

The Jacksonville Jaguars have already played more games (9) in London than any other NFL team and this is the first of two games they will play in London this season. The Jaguars are coming off a surprising playoff run last season and remain the consensus favorites to repeat as AFC South champions with Trevor Lawrence leading a talented cast of skill players. 

Miami Dolphins at Buffalo Bills

Sunday, 1 p.m. ET, CBS

The Buffalo Bills rolled to a home win over the Raiders in Week 2 after dropping their opener at the Jets. Josh Allen has been among the NFL passing leaders in three consecutive seasons and the Bills are using second-year back James Cook as a featured option.  

The Miami Dolphins have run an explosive offense over the past two seasons under new coach Mike McDaniel. Tyreek Hill and Jaylen Waddle are two of the fastest receivers in football and Raheem Mostert is a speedster out of the backfield.

Denver Broncos at Chicago Bears

Sunday, 1 p.m. ET, CBS

The Denver Broncos are looking to bounce back from a rough 5-12 campaign under Nathaniel Hackett. Sean Payton has taken over as head coach and the Broncos got Jerry Jeudy back from a hamstring injury to serve as a top option for Russell Wilson

The Chicago Bears are rebuilding around Justin Fields and they traded the top overall pick this offseason for wide receiver D.J. Moore. The Bears defense has allowed the second-most PPG (32.5) through two weeks.

Baltimore Ravens at Cleveland Browns

Sunday, 1 p.m. ET, CBS

The Baltimore Ravens are dealing with a number of key injuries early in the season, with starting linemen Ronnie Staley and Mark Lindenbaum questionable along with defensive backs Marcus Williams and Marlon Humphrey. Pro Bowl tight end Mark Andrews started in Week 2 after missing their opener with a quad injury. 

The Cleveland Browns gave Deshaun Watson a massive contract last offseason and Watson struggled after coming back from suspension in Week 13. A run-first team, the Browns lost Pro Bowl tackle Jack Conklin and pro bowl running back Nick Chubb to season-ending knee injuries. They signed Kareem Hunt on Sept. 20.

Cincinnati Bengals at Tennessee Titans

Sunday, 1 p.m. ET, Fox

The Cincinnati Bengals have reached consecutive AFC Championship games after starting slowly the past two seasons. This year, Joe Burrow is dealing with a calf strain that might be hampering his early production. The Bengals lost veteran safeties Von Bell and Jessie Bates in free agency this offseason. 

The Tennessee Titans are a run-first team that has finished among the league’s leaders in rush defense in each of the past two seasons. Veteran receiver DeAndre Hopkins has been playing through an ankle injury and second-year receiver Treylon Burks suffered a knee injury this preseason.

Los Angeles Rams at Indianapolis Colts

Sunday, 1 p.m. ET, Fox

The Los Angeles Rams will be without elite wide receiver Cooper Kupp (hamstring) for at least one more week. Rookie Puka Nacua and second-year receiver Tutu Atwell have picked up the slack, and second-year running back Kyren Williams has taken over starting duties in the backfield for Sean McVay’s squad. Cam Akers is rumored to be on the trading block.  

The Indianapolis Colts will be without former rushing leader Jonathan Taylor (ankle) for at least one more week. Zack Moss has been leading the Colts backfield with rookie quarterback Anthony Richardson showcasing his running ability when active.

Tampa Bay Buccaneers at New Orleans Saints

Sunday, 1 p.m. ET, Fox

The Tampa Bay Buccaneers are starting Baker Mayfield at quarterback and utilizing Rachaad White as a featured back following the release of Leonard Fournette. Mike Evans has put contract negotiations on hold and has been producing for Tampa early in the season. 

The New Orleans Saints entered the season as the favorites to win the NFC South with Derek Carr taking over at quarterback. Carr has shared reps under center with gadget specialist Taysom Hill. The Saints welcome Alvin Kamara back from suspension in Week 4.

Washington Commanders at Philadelphia Eagles

Sunday, 1 p.m. ET, Fox

Sam Howell got one start last year for the Washington Commanders and he’s been learning on the job early in the season. The Commanders have an elite pass rush with Chase Young (neck) back in the lineup alongside Jonathan Allen

The Philadelphia Eagles won 15 games last season and made it to the Super Bowl. They are using a deep backfield rotation this season following the offseason acquisitions of Rashaad Penny and D’Andre Swift. Defensive tackle Jalen Carter is an early favorite for Defensive Player of the Year.

Minnesota Vikings at Carolina Panthers

Sunday, 1 p.m. ET, CBS

The Minnesota Vikings use a pass-first offense with Kirk Cousins targeting reigning Offensive Player of the Year Justin Jefferson, rookie Jordan Addison, and tight end T.J. Hockenson, who was acquired ahead of the trade deadline last season. 

The Carolina Panthers traded up and selected Bryce Young with the first overall pick this year. They are giving the Alabama product plenty of opportunities to learn on the job. Their defense is loaded with talent, but cornerback Jaycee Horn (hamstring) is on injured reserve.

Pittsburgh Steelers at Houston Texans

Sunday, 1 p.m. ET, CBS

The Pittsburgh Steelers have finished with a winning record in 16 consecutive seasons under Mike Tomlin. Their defense remains strong despite the loss of Cam Heyward (groin), with T.J. Watt again in the mix for Defensive Player of the Year. 

The Houston Texans are a very youthful team on offense with rookie C.J. Stroud targeting rookie Tank Dell and handing off to second-year back Dameon Pierce. Their offensive line has been beset by injuries early in the season.

Las Vegas Raiders at Los Angeles Chargers

Sunday, 4:05 p.m. ET, CBS

The Las Vegas Raiders signed Jakobi Meyers to complement top receiver Davante Adams and were able to negotiate a one-year extension with reigning NFL rushing leader Josh Jacobs. Their defense allowed the highest completion rate (81.7%) through two games.  

The Los Angeles Chargers brought in new offensive coordinator Kellen Moore this offseason and gave Justin Herbert a handsome extension. Their defense has underperformed early on with linebacker Eric Kendricks and defensive end Joey Bosa hobbled by injuries.

New England Patriots at Dallas Cowboys

Sunday, 4:25 p.m. ET, Fox

The New England Patriots are facing the toughest schedule in the NFL this season according to preseason win projections. Their defensive line is among the most disciplined units in football and their offense has shown steady improvement under offensive coordinator Bill O’Brien.  

The Dallas Cowboys have roared to impressive opening wins to start the season with their defense allowing a league-low 193 yards and 5 points per game. Micah Parsons has been the catalyst behind that dominance with plenty of talent behind him in the secondary.

Arizona Cardinals at San Francisco 49ers

Sunday, 4:25 p.m. ET, Fox

The Arizona Cardinals came into this season with the lowest projected win total in the NFL. Joshua Dobbs is their starting quarterback with Kyler Murray (ACL) opening the year on the physically unable to perform list. 

The San Francisco 49ers are currently the Super Bowl favorites with extremely short odds to win the NFC West. The Niners offense has been even more productive since they acquired Christian McCaffrey ahead of the trade deadline last season.

Kansas City Chiefs at New York Jets

Sunday Night Football, 8:20 p.m. ET, NBC

The Kansas City Chiefs have won seven consecutive AFC West titles and won two Super Bowls over the past four seasons. Patrick Mahomes and Travis Kelce have formed one of the most productive partnerships in NFL history and Chris Jones is back to lead a strong defense. 

The New York Jets had to recalibrate expectations after losing Aaron Rodgers (Achilles) for the season on his first series with the team. Second-year running back Breece Hall could become the focal point of their offense once he gets back to full speed after suffering an ACL tear last year

Seattle Seahawks at New York Giants

Monday Night Football, 8:15 p.m. ET, ESPN

The Seattle Seahawks were one of the highest-scoring teams in the NFL last season and their defense coughed up the fifth-most total yards per game (369.7). They’ve been dealing with key injuries in the secondary early this season with safety Jamal Adams (quad) out and top cornerback Riq Woolen (rib) bothered by an injury. 

The New York Giants suffered a blowout loss in their opener and clawed back for a franchise-setting comeback to beat the Cardinals in Week 2. Saquon Barkley is week-to-week with an ankle injury.

Week 4 player props

NFL bettors have a lot to choose from when it comes to team and player props, including touchdown props and receiving props. To peruse the options, you can select a type of prop bet via the drop-down menu below. When this NFL week nears, the table will show game-specific props.

In the meantime, the odds in the table are for total touchdowns from a skill player for the season. If you wish to place a bet, you can click on the odds to head to the sportsbook offering that wager.

More NFL weekly odds content

Find more odds for every NFL week as well as detailed analysis and breakdowns.