2023 NFL Week 3 Odds: Spreads, Totals, Props For Every Game

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The 2023 NFL season rolls on with Week 3 beginning on Thursday, Sept. 21, with a primetime matchup between the New York Giants and San Francisco 49ers. One of the top matchups on Sunday afternoon features the New York Jets hosting the New England Patriots in an early afternoon game.

For the second consecutive week, Monday Night Football will have two games staggered on ABC and ESPN. In the first game, the Philadelphia Eagles take on the Tampa Bay Buccaneers. For the other, the Cincinnati Bengals host the Los Angeles Rams.

NFL Week 3 odds

Below is a table showing all available and up-to-date NFL odds for Week 3 games. Choose between wagering on spreads, moneylines, and totals. If you see a bet you like, click on the odds to go to the sportsbook and place that wager.

NFL Week 3 updated odds and lines

Looking for the most up-to-date Week 3 NFL lines? The following lists show odds for the main three bets:

NFL Week 3 spread odds

NFL Week 3 moneyline odds

NFL Week 3 over/under odds

NFL Week 3 matchups and best odds

All teams will play in the third week of the NFL season. Sunday features nine games at 1 p.m. ET, with three contests later in the afternoon. Here’s a breakdown of all the games and the best NFL betting lines for each one.

New York Giants at San Francisco 49ers

Thursday Night Football, 8:15 p.m. ET, Prime Video

The New York Giants rallied back from a 28-7 deficit in the second half to beat the Cardinals in Arizona, but star running back Saquon Barkley suffered an ankle injury on their final series. The Giants defense has allowed 34 points per game through their first two contests this season. 

The San Francisco 49ers have won 12 straight regular season games and are averaging 33.2 points per game in Brock Purdys nine starts. They are among the Super Bowl favorites this season and had a relatively short trip home for this Thursday Night matchup after beating the Rams in Los Angeles.

Tennessee Titans at Cleveland Browns

Sunday, 1 p.m. ET, CBS

The Tennessee Titans have had a lot of turnover on the offensive line over the past couple of seasons, which has contributed to Ryan Tannehill absorbing eight sacks through their first two games. Derrick Henry remains the focal point of their offense with veteran DeAndre Hopkins providing a top option in the passing game. 

The Cleveland Browns lost elite offensive tackle Jack Conklin to a season-ending knee injury in Week 1. They signed veteran Ty Nsekhe and have 6-foot-8 rookie Dawand Jones as options to fill in. Lead back Nick Chubb suffered a season-ending knee injury in a Week 2 loss at Pittsburgh.

Atlanta Falcons at Detroit Lions

Sunday, 1 p.m. ET, Fox

The Atlanta Falcons have used a run-heavy approach under Arthur Smith, but they had to open their playbook a bit more after falling into a 24-12 hole against the Packers in Week 2. Desmond Ridder led three different scoring drives and rookie Bijan Robinson converted a huge fourth down to lift the Falcons in their second win. 

The Detroit Lions finished last season strong and opened Week 1 with a 21-20 win at Kansas City. They’re averaging 393 yards per game so far this season, but could be without lead back David Montgomery (knee) and guard Halapoulivaati Vaitai (knee) in Week 3.

New Orleans Saints at Green Bay Packers

Sunday, 1 p.m. ET, Fox

Derek Carr is running the Saints’ multiple offense with Taysom Hill mixing in under center as a dual-threat quarterback. The Saints lost Jamaal Williams to a hamstring injury in Week 2 and will be without Alvin Kamara (suspension) for a third game to open the season.

Jordan Love has tossed six touchdowns without an interception so far this season for the Green Bay Packers. The Packers have been without top receiver Christian Watson (hamstring) in both games and missed lead back Aaron Jones (hamstring) in a Week 2 loss at Atlanta.

Denver Broncos at Miami Dolphins

Sunday, 1 p.m. ET, CBS

The Denver Broncos have dropped a pair of one-score games at home to open the season after hiring head coach Sean Payton to a massive contract this offseason. Denver’s secondary is led by talented young cornerback Patrick Surtain II and safety Justin Simmons

The Miami Dolphins run an explosive and aggressive offense under Mike McDaniel with Tua Tagovailoa primarily distributing the ball to top options Tyreek Hill and Jaylen Waddle. Miami has upgraded its defense through trades and free agency.

Los Angeles Chargers at Minnesota Vikings

Sunday, 1 p.m. ET, Fox

The Los Angeles Chargers lost a shootout to Miami in their home opener and fell in overtime at Tennessee in Week 2 without lead back Austin Ekeler (ankle). Linebackers Eric Kendricks and Daiyan Henley are both dealing with hamstring injuries and defensive end Joey Bosa battled through a hamstring issue at Tennessee.

The Minnesota Vikings will be on extra rest after losing at Philadelphia last Thursday. Reigning Offensive Player of the Year Justin Jefferson has led the Vikings offense with 20 catches for 309 yards through two games.

New England Patriots at New York Jets

Sunday, 1 p.m. ET, CBS

Bill Belichick organizes the defense for the New England Patriots and the team brought Bill O’Brien back this season for a second stint as offensive coordinator. The Patriots have started 0-2 for the first time since 2001.

The New York Jets turned back to Zach Wilson as their starting quarterback after Aaron Rodgers suffered a season-ending Achilles injury. Their running game has yet to get fully on track with Breece Hall working his way back from knee surgery.

Buffalo Bills at Washington Commanders

Sunday, 1 p.m. ET, CBS

After losing to the Jets in overtime, the Buffalo Bills returned home and rolled to a 38-10 win over the Raiders in Week 2. James Cook has become a workhorse back for a Bills offense that still runs through Josh Allen and top receiver Stefon Diggs

The Washington Commanders rallied from a 21-3 deficit to earn a 35-33 win in Denver behind a strong performance from second-year quarterback Sam Howell. Washington’s top receiver, Terry McLaurin, has been dealing with a turf toe injury. Tight end Logan Thomas is in concussion protocol. 

Houston Texans at Jacksonville Jaguars

Sunday, 1 p.m. ET, Fox

The Houston Texans allowed the most rushing yards in the NFL last season and they’ve given up six rushing touchdowns through two games this season. Rookie C.J. Stroud has tallied the second-most completions (58) through the first two starts of a career. Houston’s offensive line has been beset by injuries. 

The Jacksonville Jaguars are the favorites in the AFC South after winning the division with a 9-8 record last season. Calvin Ridley has returned from a year-long suspension to give Trevor Lawrence a top receiver to target. 

Indianapolis Colts at Baltimore Ravens

Sunday, 1 p.m. ET, CBS

Anthony Richardson is off to a good start as the starting quarterback for the Indianapolis Colts this season. Richardson was knocked out of the Colts’ Week 2 win with a concussion and backup Gardner Minshew (19-for-23, 171 yards, TD) filled in. 

The Baltimore Ravens have dealt with a number of injuries already this season and OT Ronnie Stanley (knee) and safety Marcus Williams (pec) will likely remain out for several weeks. Pro bowl tight end Mark Andrews (quad) made his debut in Week 2. Veteran receiver Odell Beckham Jr. (ankle) and edge rusher Odafe Oweh (shoulder) suffered injuries during their win at Cincinnati. 

Carolina Panthers at Seattle Seahawks

Sunday, 4:05 p.m. ET, CBS

The Carolina Panthers traded up to select Bryce Young first overall this season and plan to give the Alabama product a long leash as their starter. Their defense is loaded with top draft picks in the secondary and an elite pass rusher in Brian Burns

The Seattle Seahawks struggled in the second half of their home opener against the Rams after losing both of their starting offensive tackles to injuries. Geno Smith led the offense in a bounce back performance to win at Detroit. Top cornerback Riq Woolen (chest) left the game and safety Jamal Adams continues to work his way back from a quad injury.

Chicago Bears at Kansas City Chiefs

Sunday, 4:25 p.m. ET, Fox

The Chicago Bears have lost 12 straight games dating back to last season. Their defense is allowing 32.5 points per game and 383 total yards per game during an 0-2 start this year. 

The Kansas City Chiefs are perennial Super Bowl favorites with two titles over the past four seasons. Travis Kelce returned from a knee injury in a Week 2 win at Jacksonville and ChrisJones rejoined the team after holding out for a contract extension this preseason.

Dallas Cowboys at Arizona Cardinals

Sunday, 4:25 p.m. ET, Fox

The Dallas Cowboys have impressed this season while beating the Giants and Jets by a combined margin of 70-10. Micah Parsons leads a star-studded defense that now includes former Defensive Player of the Year Stephon Gillmore at cornerback. 

The Arizona Cardinals entered the season with the lowest projected win total (4.5) in the NFL. They led late at Washington in Week 1 and opened a 28-7 lead over the Giants in their home opener before losing both contests.

Pittsburgh Steelers at Las Vegas Raiders

Sunday Night Football, 8:20 p.m. ET, NBC

The Pittsburgh Steelers rode their defense to a divisional win over the Browns on Monday night. After opening with two home games, the Steelers travel across the country for this matchup. Kenny Pickett has won six of his last eight starts. 

The Las Vegas Raiders have turned to Jimmy Garoppolo at quarterback and were able to bring back Josh Jacobs on a one-year deal after he led the NFL in rushing yards last season. Jakobi Meyers missed Week 2 after suffering a concussion and Davante Adams was evaluated for a concussion during the Raiders loss at Buffalo.

Philadelphia Eagles at Tampa Bay Buccaneers

Monday Night Football, 7:15 p.m. ET, ABC

The Philadelphia Eagles used Kenneth Gainwell as their lead back in Week 1 and then gave D’Andre Swift the bulk of the backfield touches in a Thursday Night win over Minnesota with Gainwell inactive due to a rib injury. Jalen Hurts finished second in MVP voting last season and led the Eagles to a Super Bowl appearance. 

The Tampa Bay Buccaneers are off to a 2-0 start with Baker Mayfield under center. Their defense has produced five takeaways and the offense has yet to turn the ball over.

Los Angeles Rams at Cincinnati Bengals

Monday Night Football, 8:15 p.m. ET, ESPN

The Los Angeles Rams beat the Bengals in Super Bowl LVI two years ago, then struggled with injuries en route to a 5-12 record last year. Sean McVay brought in 10 new assistant coaches this offseason and his offensive personnel is different with rookie receiver Puka Nacua and second-year back Kyren Williams playing major roles. 

The Cincinnati Bengals have struggled in their first two games this year after Joe Burrow (calf) missed most of training camp and is considered day-to-day after aggravating his calf in Week 2. They lost veteran safeties Jessie Bates and Von Bell to free agency this offseason.

Week 3 player props

The table below will have a look at notable team and player props for the upcoming games, including touchdown props and receiving props. You can use the drop-down menu to select the type of bet. When this NFL week nears, the following table will show game-specific props.

In the meantime, the odds in the table are for total rushing and receiving touchdowns on the season. Clicking any of the odds will let you place a bet on that specific prop.

More NFL weekly odds content

Find more odds for every NFL week as well as detailed analysis and breakdowns.