The page turns to Week 10 of the NFL season, and odds are posted for the 14-game slate. There are several intriguing highlights on tap, including an international showdown between the Seahawks and Buccaneers, the first-ever regular season game in Germany.
In this article, we provide current NFL Week 10 spreads, moneylines, and totals, along with key storylines to keep in mind before placing bets at legal sports betting sites.
Analysis will be added as news develops.
NFL Week 10 opening odds
Week 10 best odds and betting breakdown
Atlanta Falcons at Carolina Panthers
- Spread: Falcons , Panthers
- Moneyline: Falcons , Panthers
The week begins with a Thursday night showdown between a pair of NFC South teams. The Falcons have been much better than expected this season and enter at 4-5 following a close loss to the Chargers. The Panthers were hammered by the Bengals to fall to 2-7. Baker Mayfield handled mop-up duties in relief of the ineffective PJ Walker and threw for a pair of scores. We’ll have to wait and see who gets the starting nod for TNF.
Seattle Seahawks at Tampa Bay Buccaneers (Germany)
- Spread: Seahawks , Buccaneers
- Moneyline: Seahawks , Buccaneers
The red-hot Seahawks are off to Munich. The team picked up its fourth-straight win on Sunday, this time at the expense of the Cardinals. Now 6-3, Seattle is on top of the NFC West and has wildly exceeded expectations thus far. The same can’t be said for the Buccaneers. While the team pulled out a thrilling come-from-behind win over the Rams on Sunday, the 4-5 record stands as the bottom line for one of the preseason title favorites.
Minnesota Vikings at Buffalo Bills
- Spread: Vikings , Bills
- Moneyline: Vikings , Bills
The Vikings extended their winning streak to six games with a win over the Commanders. Now 7-1, the club is in complete control of the NFC North chase. The Bills were stunned by the Jets to fall to 6-2. In a season that has been filled with big upsets, this is one of the biggest to date as Buffalo walked onto the field as 10.5-point favorites. The misstep aside, this is a potential big game preview between two of the top favorites in Super Bowl futures.
Detroit Lions at Chicago Bears
- Spread: Lions , Bears
- Moneyline: Lions , Bears
The Lions put forth their best defensive effort of the season in a 15-9 upset over the Packers. The victory snapped a five-game losing streak and brought the record to 2-6. They’ll look to keep the momentum going at the NFC North rival Bears. Chicago fell to 3-6 with a 35-32 loss to the Dolphins. Justin Fields set an NFL record in the loss by rushing for 178 yards, the most ever by a QB in a regular season game.
Denver Broncos at Tennessee Titans
- Spread: Broncos , Titans
- Moneyline: Broncos , Titans
The Broncos return from a bye week with a record of 3-5. The club entered the season with postseason aspirations following the trade for Russell Wilson, but they now find themselves with plenty of ground to make up. They’ll be on the road to take on a Titans team that brings a five-game winning streak into Sunday night’s game with the Chiefs. Derrick Henry is back in the hunt for a rushing yard title following a stellar stretch of games.
Jacksonville Jaguars at Kansas City Chiefs
- Spread: Jaguars , Chiefs
- Moneyline: Jaguars , Chiefs
The Jaguars snapped a five-game losing streak with a 27-20 win over the Raiders. The team opened the year with some promise at 2-1, but they’ve fallen to 3-6 and have plenty of work to do if they hope to be in the AFC playoff chase. The Chiefs are 5-2 as they head into the SNF date with Tennessee. The club is currently tops in the league with an average of 31.9 points per game, while Patrick Mahomes is among the favorites in MVP odds.
Cleveland Browns at Miami Dolphins
- Spread: Browns , Dolphins
- Moneyline: Browns , Dolphins
The Browns are back from a bye with a record of 3-5. They managed to enter the break on a high note with a convincing win over the Bengals. Jacoby Brissett remains under center. Deshaun Watson is eligible to begin practicing next week and will likely take over in early December. Cleveland is on the road to take on a Dolphins team that has won three straight to get to 6-3. Tua Tagovailoa was excellent in the win, throwing for 302 yards and a trio of TDs.
Houston Texans at New York Giants
- Spread: Texans , Giants
- Moneyline: Texans , Giants
The Texans have a little extra time to prepare for this one after falling to the Eagles on Thursday night to drop to 1-6-1 on the year. The club has been more competitive than expected, but reality suggests they’re on the path to a lofty pick at the next NFL Draft. The Giants are back from a bye week with a record of 6-2. The team was expected to show some improvement in year one of the Brian Daboll era. They have done that and then some.
New Orleans Saints at Pittsburgh Steelers
- Spread: Saints , Steelers
- Moneyline: Saints , Steelers
The Saints are in the Monday night spotlight for a home date with the Ravens. Last time out, the club delivered its best game of the year with a surprising shutout over the visiting Raiders. The Steelers had last week off. It has been a trying season for a 2-6 team that has dropped two straight. Pittsburgh has pulled out a pair of upsets over the Bengals and Buccaneers this season, but there hasn’t been much else to cheer about.
Indianapolis Colts at Las Vegas Raiders
- Spread: Colts , Raiders
- Moneyline: Colts , Raiders
Since making the switch to Sam Ehlinger, the Colts offense has continued to struggle. Sunday’s 26-3 loss to the Patriots was the team’s third straight defeat. Now 3-5-1, Indianapolis entered the year with playoff ambitions but is now looking for answers. They hit the road to take on the 2-6 Raiders. Las Vegas has dropped two straight and currently occupies the basement in the AFC West, a mighty fall from last year’s 10-win campaign and a postseason appearance.
Dallas Cowboys at Green Bay Packers
- Spread: Cowboys , Packers
- Moneyline: Cowboys , Packers
The Cowboys survived life without Dak Prescott just fine, and they have won two straight since his return. The team is 6-2 as they return from a bye week, hammering the visiting Bears last time out to the tune of 49-29. Dallas hits the road to take on the flailing Packers. Green Bay entered the year with big goals. They’re now 3-6 and riding a five-game losing streak, falling to the Lions on Sunday by a score of 15-9.
Arizona Cardinals at Los Angeles Rams
- Spread: Cardinals , Rams
- Moneyline: Cardinals , Rams
The Cardinals were a playoff team a season ago, but they enter the stretch run in need of a quick turnaround if they have any hopes of being a postseason contender. Arizona fell at home to the Seahawks on Sunday, the club’s second straight loss to fall to 3-6, and is in the cellar of the NFC West as they get set for a showdown with the Rams. The defending champs continue to struggle, falling to the Buccaners last time out to drop to 3-5.
Los Angeles Chargers at San Francisco 49ers
- Spread: Chargers , 49ers
- Moneyline: Chargers , 49ers
The Chargers had a battle on their hands at the Falcons on Sunday, but they managed to escape with a 3-point win to get to 5-3. The club is in the mix of contenders in the AFC wild card chase, but a pair of double-digit home losses to the Jaguars and Seahawks serve as red flags. The 49ers are 4-4 out of a bye, but the arrow is pointing up. They entered the break off of a double-digit win over the Rams behind a 3-TD day from Christian McCaffrey.
Washington Commanders at Philadelphia Eagles
- Spread: Commanders , Eagles
- Moneyline: Commanders , Eagles
The week concludes with a Monday Night Football matchup between two NFC East rivals. The Commanders lost at home to the Vikings on Sunday to fall to 4-5, snapping a three-game winning streak in the process. The Eagles easily handled the Texans on Thursday night to keep the record perfect at 8-0. Philadelphia is the NFC favorite for the big game, and currently holds a 1-game lead over the Vikings for the top seed in the conference.