Week 2 of the regular season kicked off with a thriller on Thursday Night Football. The Kansas City Chiefs had to come from behind to pull out a 3-point win over the Los Angeles Chargers.
The action continues on Sunday with a packed slate of 13 games and wraps up with a Monday Night Football doubleheader.
In this article, we have the latest NFL betting odds for all of the remaining games, plus matchup previews, player props, and more. Read on for an up-to-the-minute look at NFL Week 2 and what you need to know about betting on this week’s games.
NFL Week 2 betting odds
The table below has the latest odds for all of the remaining Week 2 games. You can use the dropdown bar to view the main pregame betting markets of spread, moneyline, and totals. When you see a bet that you like, click on your selection and you’ll be directed to the sportsbook to place it.
NFL Week 2 matchups and best odds
There are still 15 games to look forward to on the NFL Week 2 slate. Here’s a look at each matchup and the latest odds.
New York Jets at Cleveland Browns
- Spread: Jets , Browns
- Moneyline: Jets , Browns
Joe Flacco will be behind center once again as the Jets look to avoid an 0-2 start. New York couldn’t get anything going in the opener as they fell to the visiting Ravens. The Browns opened the year with a road win over the Panthers on a last-minute field goal. Jacoby Brissett continues to start for Cleveland in place of the suspended Deshaun Watson.
Tampa Bay Buccaneers at New Orleans Saints
- Spread: Buccaneers , Saints
- Moneyline: Buccaneers , Saints
The Buccaneers picked up a road win over the Cowboys with the defense being the star of the show. The Saints had to mount a furious comeback to escape with a win over the Falcons. Chris Godwin was banged up and may be unable to go for Tampa Bay, while Alvin Kamara could be sidelined with a rib injury after being a non-factor in Week 1.
Carolina Panthers at New York Giants
- Spread: Panthers , Giants
- Moneyline: Panthers , Giants
Both clubs had games that went down to the wire last week. The Panthers came up short versus the Browns, while a gutsy call by new head coach Brian Daboll and a monster day from Saquon Barkley helped push the Giants to a win over the Titans. New York rookie defender Kayvon Thibodeaux could make his debut this week after missing the opener.
New England Patriots at Pittsburgh Steelers
- Spread: Patriots , Steelers
- Moneyline: Patriots , Steelers
The Patriots are looking to bounce back from an incredibly flat performance in a loss to the Dolphins last week. Mac Jones had an injury scare, but he’s expected to be good to go this week. The Steelers’ defense made life miserable for the Bengals in an opening-week upset, but that came at a cost. TJ Watt is on IR with a pectoral injury and will miss several weeks.
Indianapolis Colts at Jacksonville Jaguars
- Spread: Colts , Jaguars
- Moneyline: Colts ), Jaguars
The Colts were huge favorites over the Texans last week, but they struggled mightily and had to rally to escape with a tie. The Jaguars had a fourth-quarter lead over the Commanders, but they couldn’t hang on and went down by a score of 28-22. Jacksonville crushed the playoff hopes of Indianapolis last year with a Week 18 upset win.
Miami Dolphins at Baltimore Ravens
- Spread: Dolphins , Ravens
- Moneyline: Dolphins , Ravens
A pair of 1-0 teams square off for a potentially intriguing showdown in Baltimore. The Ravens won by double digits over the Jets last week, while the Dolphins did the same at the expense of the Patriots. For Miami, the game was the debut for new head coach Mike McDaniel. JK Dobbins could return for Baltimore after missing the opener with a knee injury.
Washington Commanders at Detroit Lions
- Spread: Commanders , Lions
- Moneyline: Commanders , Lions
Carson Wentz made his debut for the Commanders last week and had himself a day, throwing for four scores in a win over the Jaguars. The Lions mounted a late comeback against the Eagles and covered the spread, but they came up just short. The status of Detroit RB D’Andre Swift bears watching in advance of kickoff, although he returned to practice on Friday.
Seattle Seahawks at San Francisco 49ers
- Spread: Seahawks , 49ers
- Moneyline: Seahawks , 49ers
It’s a meeting of two teams that surprised in different ways in Week 1. The Seahawks upset the Broncos as big underdogs, while the heavily favored 49ers fell to the Bears. To add to the woes for San Francisco, Elijah Mitchell is on IR and George Kittle is expected to miss this week. For Seattle, Jamal Adams is done for the year with a torn quad.
Atlanta Falcons at Los Angeles Rams
- Spread: Falcons , Rams
- Moneyline: Falcons , Rams
The Falcons lost a heartbreaker to the Saints while putting up a better-than-expected fight. The Rams looked completely out of sorts while being dominated by the Bills in the season opener. Oddsmakers are expecting a bounce-back performance for the defending Super Bowl champs as Los Angeles is a huge home favorite for this tilt.
Houston Texans at Denver Broncos
- Spread: Texans , Broncos
- Moneyline: Texans , Broncos
The Texans are expected to be among the league’s worst this year, but the team showed plenty of fight in an opening-week tie with the Colts. The Broncos vaulted up the ranks of contenders after trading for Russell Wilson, but a loss to the Seahawks in the opener took some wind out of the sails. Betting markets are suggesting that a Denver rebound is on the way.
Arizona Cardinals at Las Vegas Raiders
- Spread: Cardinals , Raiders
- Moneyline: Cardinals , Raiders
The Cardinals were run over at home by the Chiefs last week, losing by double digits, while the Raiders lost a close one to the Chargers. Arizona could be without both Rondale Moore and JJ Watt once again. New Raiders wideout Davante Adams will make his Sin City debut after displaying solid chemistry with Derek Carr in the opener.
Cincinnati Bengals at Dallas Cowboys
- Spread: Bengals , Cowboys
- Moneyline: Bengals , Cowboys
After a sloppy five-turnover performance, the Bengals actually managed to force overtime with the Steelers before going down in defeat. Cincinnati heads to Dallas to face off with a Cowboys team that lost Dak Prescott to a hand injury in a loss to the Buccaneers. Cooper Rush will take over behind center while Prescott heals up, resulting in a huge swing in betting markets on this game.
Chicago Bears at Green Bay Packers
- Spread: Bears , Packers
- Moneyline: Bears ,
A rainy day in the Windy City turned out just fine for the Bears as they pulled out a surprising win over the 49ers. There wasn’t a lot of offensive firepower on display, but Justin Fields threw for a pair of scores. The Packers were incredibly flat in an opening week defeat to the Vikings. Allen Lazard appears likely to play this week after missing Week 1 due to injury.
Tennessee Titans at Buffalo Bills
- Spread: Titans , Bills
- Moneyline: Titans , Bills
The Titans had a shot to win it late, but an errant field goal proved to be the difference maker in a 1-point loss to the visiting Giants. Derrick Henry had a pretty quiet day with 82 rushing yards. The season couldn’t have gotten off to a better start for the Bills. They crushed the Rams by a score of 31-10 behind four total TDs from Josh Allen.
Minnesota Vikings at Philadelphia Eagles
- Spread: Vikings , Eagles
- Moneyline: Vikings , Eagles
It’s a meeting of two teams that are suddenly capturing a lot of attention in the NFC playoff chase. The Vikings impressed in Kevin O’Connell’s debut with a win over the Packers, while the Eagles are the clear NFC East favorite in the wake of the Cowboys injury woes. Betting lines are pointing to a tight and potentially high-scoring game to close out Week 2.
Week 2 player props
If you enter a player’s name in the table below, you’ll see all of the currently available props along with the latest odds for each wager. When you come across an appealing option, just click on the odds for your selection and you’ll be directed to the sportsbook to place your bet.