Week 1 of the NFL regular season kicked off Thursday with a statement win by the Buffalo Bills over the defending Super Bowl champion Los Angeles Rams. The meat of the Week 1 slate takes place on Sunday, highlighted by an AFC West tilt between the Los Angeles Chargers and Las Vegas Raiders. Week 1 will be bookended by yet another entertaining game as Russell Wilson and the Denver Broncos play the Seattle Seahawks on Monday Night Football.
NFL odds are posted for all 15 remaining games. Continue reading to find current spreads, moneylines, totals, and player props, plus key storylines to pay attention to before the rest of Week 1 gets underway.
NFL Week 1 odds: Spreads, moneylines, and totals
The table below shows Week 1 lines for every game. You can use the dropdown bar to view and compare lines for every game at legal sportsbooks in the US.
For player props, scroll to the bottom of this article to find our prop search tool.
NFL Week 1 matchups and best odds
New Orleans Saints at Atlanta Falcons – 1 p.m. ET
- Spread: Saints , Falcons
- Moneyline: Saints , Falcons
A healthy Jameis Winston looks to make a comeback statement for the Saints after tearing his ACL last October. He’s surrounded by several new weapons, including rookie Chris Olave and free agent signing Jarvis Landry. Dennis Allen steps into the Saints’ head coach role in the absence of Sean Payton.
The Falcons’ Marcus Mariota will fill the QB1 vacancy now that Matt Ryan is in Indianapolis. The team also picked up a pair of receivers by drafting Drake London and trading for Bryan Edwards to offset the losses of Russell Gage, Julio Jones, and the suspended Calvin Ridley.
San Francisco 49ers at Chicago Bears – 1 p.m. ET
- Spread: 49ers , Bears
- Moneyline: 49ers , Bears
Trey Lance is locked in as the 49ers’ QB1 after a year of playing backup to Jimmy Garoppolo. The Niners came up short in the NFC title game last year with essentially the same roster, but this time supporting Lance.
Another second-year QB, Justin Fields, will take snaps for the Bears. Fields has far fewer weapons around him to materialize wins, which is reflected in betting markets for this game.
Pittsburgh Steelers at Cincinnati Bengals – 1 p.m. ET
- Spread: Steelers , Bengals
- Moneyline: Steelers , Bengals
Mitch Trubisky got the starting nod at QB ahead of Week 1 for the Steelers. Trubisky has some good offensive weapons to use to his advantage. Rookie wide receiver George Pickens was added to this receiving corps in the draft, rounding out a dynamic young crew of receivers for the Steelers. But will Trubisky have time to throw behind a patchwork offensive line?
The Bengals were a shocking Super Bowl LVI participant after entering last season as a long shot to make the playoffs. They have a chance to do it again this year as the Joe Burrow-led passing attack remains one of the most dynamic in the league. The Bengals’ offensive line is improved, but potentially still a weak point.
Philadelphia Eagles at Detroit Lions – 1 p.m. ET
- Spread: Eagles , Lions
- Moneyline: Eagles , Lions
The Eagles were a fringe postseason entrant last season and exited in the first round. They brought in talented receiver A.J. Brown during the offseason and revamped their defense. This looks like one of the most well-rounded rosters entering the season.
The Lions finished strong last year, going 3-3 in their last six games with wins over the Cardinals and the Packers. There’s talent on this squad, especially at offensive line and running back, and the defense got a boost with Aidan Hutchinson in the draft. But Detroit enters the year with a lot to prove.
New England Patriots at Miami Dolphins – 1 p.m. ET
- Spread: Patriots , Dolphins
- Moneyline: Patriots , Dolphins
The Dolphins added Tyreek Hill to their roster, giving them two fast, talented wide receivers for Tua Tagovailoa. Hill and Jaylen Waddle could cause problems for a Patriots secondary here in this AFC East battle. The Dolphins swept the Patriots last year.
The Patriots made some needed improvements to their defense this offseason and landed DeVante Parker in a trade with Miami. But preseason futures markets are telling us that this team has fallen from grace.
Baltimore Ravens at New York Jets – 1 p.m. ET
- Spread: Ravens , Jets
- Moneyline: Ravens , Jets
The Ravens had poor injury luck last year and ended up missing the playoffs. But they brought on talent in the draft and signed free agent safety Marcus Williams, who will fit in nicely with this defense. If Lamar Jackson can keep his turnovers at bay, the Ravens should bounce back. And the betting market is expecting it.
The Jets had little direction on either side of the ball last season with rookie Zach Wilson under center. Wilson could miss up to four weeks while he recovers from knee surgery, leaving the team’s fate in the hands of Joe Flacco. The Jets drafted Breece Hall, a candidate for Offensive Rookie of The Year, who should give them solid production out of the backfield. There’s no shortage of talent at the skill positions here, but getting the ball in their hands could be a difficult task.
Jacksonville Jaguars at Washington Commanders – 1 p.m. ET
- Spread: Jaguars , Commanders
- Moneyline: Jaguars , Commanders
The Jaguars will look to rebuild coming off a tough season with head coach Urban Meyer. New head coach Doug Pederson should bring stability and guidance to a team that has added a lot of young talent over the past few years. They added Christian Kirk in the offseason, giving Trevor Lawrence another steady receiver to target.
Carson Wentz will be under center for the Commanders this season after an underwhelming year in Indy. This team has talent on both sides of the ball but will be without its most impactful player, Chase Young, for at least four weeks.
Cleveland Browns at Carolina Panthers – 1 p.m. ET
- Spread: Browns , Panthers
- Moneyline: Browns , Panthers
This game is expected to be one of the most competitive in Week 1, with the spread hovering around a pick’em at sportsbooks. The Browns have endured a dramatic offseason with the trade for and then suspension of Deshaun Watson, whom they paid handsomely to acquire, and a messy breakup with Baker Mayfield, whom they face this week. Jacoby Brissett will start under center with newly acquired Amari Cooper as WR1 and the Browns’ solid defense will return to its regularly scheduled program.
Mayfield hosting his former team is the key storyline this week, but fantasy football players will have their eyes on Christian McCaffrey, who is due for a bounceback year after suffering through injuries the last few seasons. He opens up a lot for this offense and gives Mayfield a safety blanket in a new offense.
Indianapolis Colts at Houston Texans – 1 p.m. ET
- Spread: Colts , Texans
- Moneyline: Colts , Texans
The Colts narrowly missed the playoffs last year after losing to the Jacksonville Jaguars in the final week. But Matt Ryan is the new signal-caller in Indianapolis and has a stat-producing machine named Jonathon Taylor in the backfield with a great defense to support him. They are projected to win the AFC South.
This will be another rebuilding year for the Houston Texans who have finally moved away from Deshaun Watson. Starting quarterback Davis Mills, Brandin Cooks and rookie running back Dameon Pierce will try to keep them competitive.
New York Giants at Tennessee Titans – 4:25 p.m. ET
- Spread: Giants , Titans
- Moneyline: Giants , Titans
Will a new Giants head coach and general manager right the ship in New York? Daniel Jones has plenty to prove, and he’ll have a new playcaller and some shiny new toys at his disposal in this offense. But he needs to limit the turnovers that have tormented him since his debut in 2019. Saquon Barkley could be a difference-maker for this offense but needs to stay healthy, which he hasn’t been able to do since being drafted second overall.
The Titans have made a postseason run for three consecutive years, including last year as the No. 1 seed in the AFC. They traded A.J. Brown but still have Derrick Henry who is expected to be back in full form after missing a large chunk of last season.
Green Bay Packers at Minnesota Vikings – 4:25 p.m. ET
- Spread: Packers , Vikings
- Moneyline: Packers , Vikings
Aaron Rodgers is up for his third-straight MVP award, though Josh Allen is currently the favorite. Rodgers lost his partner, Davante Adams, who accounted for almost three times as many targets as the second-most targeted player on this offense last year. The offense will need to be reworked, but the defense got a huge boost in the offseason.
Among Justin Jefferson, Adam Thielen, and Dalvin Cook, Kirk Cousins has plenty of options to run a productive offense. They have had a struggling defense but new coach Kevin O’Connell is expected to help in that department and the offensive line got improvements in the offseason.
Kansas City Chiefs at Arizona Cardinals – 4:25 p.m. ET
- Spread: Chiefs , Cardinals
- Moneyline: Chiefs , Cardinals
This game has the highest projected over/under of all Week 1 games at 54 points. There have been lots of pass-catching changes on both teams:
- Tyreek Hill moved to Miami
- JuJu Smith-Schuster and Marquez Valdes-Scantling joined the Chiefs
- Christian Kirk moved to Jacksonville
- Marquise Brown joined the Cardinals
- DeAndre Hopkins is suspended
The offensive structure of these two teams is similar with two pass-heavy offenses and elite, dynamic quarterbacks leading the way. But the Cardinals have some key injuries to account for entering Sunday.
Las Vegas Raiders at Los Angeles Chargers – 4:25 p.m. ET
- Spread: Raiders , Chargers
- Moneyline: Raiders , Chargers
The last time these two teams played, the Raiders won in overtime to go to the playoffs and send the Chargers home. But the dynamic of both teams changed a lot this offseason. The Chargers traded for Khalil Mack, who elevates this pass rush alongside Joey Bosa. The defense also added J.C. Jackson, and signed Derwin James to an extension. Meanwhile, the Raiders traded for Davante Adams to give Derek Carr a top receiving option and diversify their pass catchers.
Tampa Bay Buccaneers at Dallas Cowboys – 8:20 p.m. ET
- Spread: Buccaneers , Cowboys
- Moneyline: Buccaneers , Cowboys
Dallas went 12-5 last season before losing to the 49ers in the Wild Card Round. This offense, though still very talented, lost some core pieces, which might be noticeable against a solid Tampa Bay defense. Both teams are dealing with injuries all over the field, especially on the offensive lines.
Denver Broncos at Seattle Seahawks – Monday at 8:15 p.m. ET
- Spread: Broncos , Seahawks
- Moneyline: Broncos , Seahawks
Russell Wilson will play in his first game as a Bronco, as luck would have it, at Lumen Field in Seattle. He has offensive weapons surrounding him and a revamped defense that makes Denver a dangerous contender in the AFC West this year.
Geno Smith is starting in Seattle. The veteran has shown his ability to minimize mistakes and control a game, and he’ll need to do just that to remain competitive on Monday night. Smith has a great group of receivers but not much else to work with. The betting market reflects that.
Week 1 player props
Use the table below to search for the best NFL Week 1 player props. Type a name or a team into the search bar and you’ll find all the latest prop bets on them from different sportsbooks. If you find a bet you like, click on the box and you’ll be directed to the sportsbook to place your bet.