NFL Week 2 Odds: Updated Point Spreads, Moneylines, Totals


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Betting odds are out for Week 2 of the NFL regular season. In a big AFC East matchup, the Miami Dolphins are one-point favorites as the team hosts the Buffalo Bills on Thursday Night Football to start the week. In other AFC action, the Cincinnati Bengals (+3.5) hit the road to take on the defending Super Bowl champion Kansas City Chiefs.

Sunday Night Football in Week 2 will pit the Houston Texans (-4) against the Chicago Bears in what will be Houston’s home opener. The week will wrap up with the Philadelphia Eagles (+3.5) hosting the Atlanta Falcons on Monday Night Football.

Read on for a detailed look at Week 2 betting odds from the best NFL betting sites, including spreads, moneylines, and point totals, plus the latest injury updates for every NFL team.

NFL Week 2 odds: Best available point spreads, moneylines, and totals

DateMatchupSpreadMoneylineOver/Under
Thursday,
Sept. 12,
8:15 p.m. ET
Bills @
Dolphins


O/U
Sunday,
Sept. 15,
1 p.m.
ET
49ers @
Vikings


O/U
Sunday,
Sept. 15,
1 p.m.
ET
Seahawks @ Patriots

O/U
Sunday,
Sept. 15,
1 p.m.
ET
Giants @
Commanders


O/U
Sunday,
Sept. 15,
1 p.m.
ET
Chargers @
Panthers



O/U
Sunday,
Sept. 15,
1 p.m.
ET
Saints @
Cowboys


O/U
Sunday,
Sept. 15,
1 p.m.
ET
Colts @
Packers


O/U
Sunday,
Sept. 15,
1 p.m.
ET
Browns @
Jaguars


O/U
Sunday,
Sept. 15,
1 p.m.
ET
Jets @
Titans



O/U
Sunday,
Sept. 15,
1 p.m.
ET
Buccaneers @ Lions

O/U
Sunday,
Sept. 15,
1 p.m.
ET
Raiders @
Ravens


O/U
Sunday,
Sept. 15,
4:05 p.m.
ET
Rams @
Cardinals



O/U
Sunday,
Sept. 15,
4:25 p.m.
ET
Bengals @
Chiefs


O/U
Sunday,
Sept. 15,
4:25 p.m.
ET
Steelers @
Broncos


O/U
Sunday,
Sept. 15,
6:20 p.m.
ET
Bears @
Texans




O/U
Monday,
Sept. 16,
8:15 p.m.
ET
Falcons @
Eagles


O/U

get more NFL betting info

There are more ways to bet on the NFL beyond Week 2. Learn about the best sportsbooks for betting on the NFL or take a look at specific wagers, including win totals and touchdown props.

NFL Week 2 matchups and odds

Buffalo Bills at Miami Dolphins
Thursday, 8:15 p.m. ET

The Buffalo Bills open the season at home against Arizona in Week 1. Buffalo is coming off an inconsistent season in which the team pulled it together late to win the AFC East. Sportsbooks expect QB Josh Allen to be a top MVP contender again this season, but turnovers remain an issue for him. The team traded away WR Stefon Diggs in exchange for draft picks in the offseason but picked up WR Keon Coleman in the 2024 draft.

The Miami Dolphins host the Jacksonville Jaguars in Week 1. The team was a Super Bowl favorite at various points last season but exited in the wild card round of the playoffs with a lopsided loss to Kansas City. Expectations will be high for QB Tua Tagovailoa after some of the eye-popping numbers he put up in the last campaign. The team added WR Odell Beckham Jr. to give him a solid third option in the passing game. The backfield is looking especially deep, with plenty of options at running back after injuries hampered De’Von Achane last season. The team also signed Aaron Brewer to take over as the starting center.

San Francisco 49ers at Minnesota Vikings
Sunday, 1 p.m. ET

The San Francisco 49ers play host to the Jets on Monday Night Football in the season opener. QB Brock Purdy and RB Christian McCaffrey lead an offense that is largely unchanged from last season’s NFC championship lineup. Anything less than another division title and deep playoff run will be a disappointment. San Francisco scooped up Florida WR Ricky Pearsall with its first-round pick, which should help out with depth in the passing game.

The Minnesota Vikings are on the road against the Giants in Week 1. Last season saw a rotating cast at quarterback, resulting in a 7-10 finish. Currently, Sam Darnold is projected to be the starter under center, but the team did take Michigan QB J.J. McCarthy with the 10th overall pick in the draft. Training camp could bring some upheavals in that department.

Seattle Seahawks at New England Patriots
Sunday, 1 p.m. ET

The Seattle Seahawks host AFC West rival Denver to start the season. QB Geno Smith will be looking to justify the team’s continued commitment to him this year, and he’ll have some help with WR DK Metcalf and Tyler Lockett among the options at receiver. The team focused largely on defense in the draft, taking DT Byron Murphy out of Texas with its first-round pick.

The New England Patriots start the season on the road in Cincinnati. New head coach Jerod Mayo is looking to help the team get a fresh start after a painful 4-13 finish last season. New England used the third overall draft pick to add North Carolina QB Drake Maye, who should get a chance to compete for the starting role in training camp. Currently, Jacoby Brissett is expected to be the starter at quarterback.

New York Giants at Washington Commanders
Sunday, 1 p.m. ET

The New York Giants are at home against Minnesota in Week 1. The quarterback situation remains the biggest concern for the team, with QB Daniel Jones coming off an injury-plagued season. The team toyed with the idea of trading up in the draft for a backup option under center, but that move ultimately didn’t pan out. New York did add LSU WR Malik Nabers with the sixth overall pick in the draft.

The Washington Commanders start the season on the road against Tampa Bay. New head coach Dan Quinn is looking to turn around a team that was the worst in the NFC East last year. Washington used the No. 2 pick in the draft to take QB Jayden Daniels, and the pressure will be on him to come in and produce right away during his rookie season.

Los Angeles Chargers at Carolina Panthers
Sunday, 1 p.m. ET

The Los Angeles Chargers are at home in Week 1 to take on the Raiders. QB Justin Herbert is returning from a finger injury that sidelined him late last season. The team is looking at a somewhat thin group at receiver, and much of its focus in the draft was on the defensive side of the ball after adding Joe Alt to the offensive line with its first-round pick.

The Carolina Panthers start the season on the road against New Orleans. After winning just two games last season, this is a young team with nowhere to go but up. QB Bryce Young will have even more of the load to carry in his second season, but there were encouraging flashes at points in his rookie year. The team added South Carolina WR Xavier Legette to give him more options downfield this season.

New Orleans Saints at Dallas Cowboys
Sunday, 1 p.m. ET

The New Orleans Saints are at home against the Panthers in Week 1. QB Derek Carr should have a better offensive line to work with this season, but a key will be keeping RB Alvin Kamara healthy to boost the running game. There could be a competition between Jake Haener and Spencer Rattler for the QB2 spot.

The Dallas Cowboys are on the road against Cleveland to start the season. Dallas was the best home team in the NFL last year. QB Dak Prescott inked a huge contract in the offseason, so pressure will be on to deliver right away in order to prove he’s worth it. WR CeeDee Lamb and Brandin Cooks are expected to be the key components in the passing game, but the team will also get RB Ezekiel Elliott back after he spent last season with New England.

Indianapolis Colts at Green Bay Packers
Sunday, 1 p.m. ET

The Indianapolis Colts begin Week 1 at home against Houston. QB Anthony Richardson is still dealing with an AC joint issue. Indianapolis added Joe Flacco as a backup after his strong relief effort in Cleveland last season and used a first-round draft pick to nab edge rusher Laiatu Latu.

The Green Bay Packers head to Brazil in Week 1 for a historic NFL first against Philadelphia. The team is hoping for a better running game after signing RB Josh Jacobs as a free agent, plus adding USC’s MarShawn Lloyd in the draft. The team also signed RB AJ Dillon to a one-year deal, so there’s no shortage of backfield options to start the season.

Cleveland Browns at Jacksonville Jaguars
Sunday, 1 p.m. ET

The Cleveland Browns are at home against Dallas in Week 1. The biggest questions are still at quarterback, with Deshaun Watson and backup Dorian Thompson-Robinson both beginning training camp with injury questions. RB Nick Chubb is expected to return from a devastating knee injury that ended his season early last year.

The Jacksonville Jaguars start the year on the road in Miami. The team exercised the option on QB Trevor Lawrence’s contract in the offseason, keeping him in Jacksonville for the time being. Injuries to the receiving corps only contributed to the concerns there, but the Jaguars aimed to address that need by using their first-round pick to select Louisiana State receiver Brian Thomas Jr. in this year’s draft.

New York Jets at Tennessee Titans
Sunday, 1 p.m. ET

The New York Jets start the season on the road against the 49ers in the first installment of Monday Night Football. The team lost QB Aaron Rodgers to an Achilles tendon injury at the start of last season but is hopeful that he’ll be back in plenty of time to start this campaign. The Jets also acquired Tyrod Taylor as a backup, plus bolstering the offensive line with Morgan Moses and John Simpson.

The Tennessee Titans are on the road against the Bears in Week 1. QB Will Levis will have high hopes to live up to in his second season after showing some promise as a rookie. The Titans knew they needed to improve protection for Levis, which is part of the reason the team used the seventh overall draft pick to get T J.C. Latham out of Alabama.

Tampa Bay Buccaneers at Detroit Lions
Sunday, 1 p.m. ET

The Tampa Bay Buccaneers begin the season at home against the Commanders in Week 1. After getting more than expected out of QB Baker Mayfield last season, the team focused on other needs in the draft, using its first pick to add to its offensive line with Duke’s Graham Barton. The core of last season’s team is still intact, but Tampa Bay is hoping for major improvements in the pass rush game.

The Detroit Lions host the Rams in Week 1. QB Jared Goff is firmly entrenched as the starter under center after a big contract extension in the offseason, but this time Detroit won’t surprise anyone. The team won the NFC North last season and is the favorite to do so again. The Lions improved their defensive backfield in the draft, selecting Terrion Arnold in the first round, followed by Ennis Rakestraw Jr. in the second.

Las Vegas Raiders at Baltimore Ravens
Sunday, 1 p.m. ET

The Las Vegas Raiders are on the road against the Chargers in Week 1, beginning the season against a division rival. New GM Tom Telesco is trying to turn things around with Antonio Pierce getting his first full season as the head coach. QB Aidan O’Connell looks to have the inside track on the starting spot, though Gardner Minshew could also compete. WR Davante Adams should be a big piece of the offense this year, regardless of who’s taking the snaps.

The Baltimore Ravens begin Week 1 in the Thursday night season-opener at Kansas City. Baltimore was the AFC’s best team headed into the playoffs last season, so expectations are high once again for QB Lamar Jackson coming off an MVP campaign. Baltimore suffered extensive free agency losses, which included several offensive linemen and the team’s top edge rusher in Jadeveon Clowney. The team did sign RB Derrick Henry, who leads the league in rushing yards compiled since 2018.

Los Angeles Rams at Arizona Cardinals
Sunday, 4:05 p.m. ET

The Los Angeles Rams are on the road against Detroit in Week 1. The team is looking to improve on a second-place finish in the NFC West last season. QB Matthew Stafford is still the focus under center, but the Rams did add Jimmy Garoppolo as a backup option. Los Angeles also drafted Florida State’s Jared Verse, hoping to fill the big shoes of Aaron Donald after his retirement.

The Arizona Cardinals start the season on the road in Week 1, taking on the Bills. The team will be hoping for a full season out of a healthy QB Kyler Murray, who returned from knee injury late last year. Arizona will also have Desmond Ridder as a backup option. There are high hopes for rookie WR Marvin Harrison Jr. to add an explosive downfield threat to an offense that sorely needs one.

Cincinnati Bengals at Kansas City Chiefs
Sunday, 4:25 p.m. ET

The Cincinnati Bengals will be at home against New England in Week 1 this season. The focus through training camp will be keeping Joe Burrow healthy after last season’s injury woes started almost as soon as practices did. Burrow is among the top MVP candidates again this year, and the team added to its offensive line with T Amarius Mims in the first round of the draft, hopefully shoring up protection.

The Kansas City Chiefs open the entire NFL season once again, this time at home against the Ravens. QB Patrick Mahomes is once again an early MVP favorite, but it remains to be seen whether Kansas City will get off to another sluggish start after winning a second straight Super Bowl title. The Chiefs lost offensive lineman Nick Allegretti to free agency but signed WR Marquise Brown. QB Carson Wentz has been added to the roster as a backup option for Mahomes.

Pittsburgh Steelers at Denver Broncos
Sunday, 4:25 p.m. ET

The Pittsburgh Steelers will start the season on the road against Atlanta in Week 1. The quarterback situation could get interesting after the team added both Russell Wilson and Justin Fields in the offseason. T.J. Watt looks to be healthy headed into training camp, giving the team back its top star on defense. CB Cameron Sutton will miss the first eight games of the season due to a suspension for violating the league’s personal conduct policy.

The Denver Broncos are on the road against Seattle to start this season. Denver will be hoping for a lot out of rookie QB Bo Nix, though it also has Zach Wilson as an option if Nix isn’t ready to start right away. The Broncos also added WR Josh Reynolds as a free agent pickup and agreed to a four-year extension with G Quinn Meinerz.

Chicago Bears vs. Houston Texans
Sunday, 6:25 p.m. ET

The Chicago Bears are at home against the Titans in Week 1. The team is looking to retool this season, which has so far included moves like trading QB Justin Fields to Pittsburgh in exchange for a 2025 draft pick. Chicago will be expecting USC quarterback Caleb Williams to start right away after selecting him in this year’s draft.

The Houston Texans had a breakthrough season last time out, winning the AFC South with a big assist from offensive rookie of the year C.J. Stroud at quarterback. Houston traded out of a first-round pick in the 2024 NFL draft but used its remaining picks to address needs in the defensive backfield and offensive line. Expectations will be higher this season, and a deep backfield including RB Joe Mixon could help.

Atlanta Falcons at Philadelphia Eagles
Monday, 8:15 p.m. ET

The Atlanta Falcons are at home against Pittsburgh in Week 1. The team raised eyebrows by drafting QB Michael Penix Jr. in the first round soon after acquiring Kirk Cousins, though Cousins looks to be the starter for now. The Falcons also added WR Darnell Mooney and will be expecting a lot of RB Bijan Robinson in his second season.

The Philadelphia Eagles start the season in Brazil, taking on Green Bay in a rare Friday game in Week 1. Much of the offseason focus has been on shoring up what had been a problematic defensive backfield. The team reacquired C.J. Gardner-Johnson after he spent last season in Detroit. The Eagles will also have a lot of options at quarterback, with Kenny Pickett and Tanner McKee backing up Jalen Hurts.